TY - JOUR
T1 - Traditional Chinese medicine compounds regulate autophagy for treating neurodegenerative disease
T2 - A mechanism review
AU - Wang, Zi Ying
AU - Liu, Jia
AU - Zhu, Zhou
AU - Su, Cheng Fu
AU - Sreenivasmurthy, Sravan Gopalkrishnashetty
AU - Iyaswamy, Ashok
AU - Lu, Jia Hong
AU - Chen, Gang
AU - Song, Ju Xian
AU - Li, Min
N1 - Funding Information:
This study was supported by the National Natural Science Foundation of China (NSFC-81703487, NSFC-81773926), the General Research Fund (HKBU12101417, HKBU12100618) and the Hong Kong Health and Medical Research Fund (HMRF17182541, HMRF17182551) from Hong Kong Government, Research Funds (JCYJ 20180302174028790, JCYJ20180507184656626) from Shenzhen Science and Technology Innovation Commission, and Research Funds (RC-IRCs/17-18/03, RC-IRCMS/19-20/H02) from Hong Kong Baptist University. The authors would like to thank Dr. Martha Dahlen for her English editing.
Publisher copyright:
© 2020 The Authors. Published by Elsevier Masson SAS.
PY - 2021/1
Y1 - 2021/1
N2 - Neurodegenerative diseases (NDs) are common chronic diseases related to progressive damage of the nervous system. Globally, the number of people with an ND is dramatically increasing consistent with the fast aging of society and one of the common features of NDs is the abnormal aggregation of diverse proteins. Autophagy is the main process by which misfolded proteins and damaged organelles are removed from cells. It has been found that the impairment of autophagy is associated with many NDs, suggesting that autophagy has a vital role in the neurodegeneration process. Recently, more and more studies have reported that autophagy inducers display a protective role in different ND experimental models, suggesting that enhancement of autophagy could be a potential therapy for NDs. In this review, the evidence for beneficial effects of traditional Chinese medicine (TCM) regulate autophagy in the models of Alzheimer's disease (AD), Parkinson's disease (PD), and other NDs are presented and common autophagy-related mechanisms are identified. The results demonstrate that TCM which regulate autophagy are potential therapeutic candidates for ND treatment.
AB - Neurodegenerative diseases (NDs) are common chronic diseases related to progressive damage of the nervous system. Globally, the number of people with an ND is dramatically increasing consistent with the fast aging of society and one of the common features of NDs is the abnormal aggregation of diverse proteins. Autophagy is the main process by which misfolded proteins and damaged organelles are removed from cells. It has been found that the impairment of autophagy is associated with many NDs, suggesting that autophagy has a vital role in the neurodegeneration process. Recently, more and more studies have reported that autophagy inducers display a protective role in different ND experimental models, suggesting that enhancement of autophagy could be a potential therapy for NDs. In this review, the evidence for beneficial effects of traditional Chinese medicine (TCM) regulate autophagy in the models of Alzheimer's disease (AD), Parkinson's disease (PD), and other NDs are presented and common autophagy-related mechanisms are identified. The results demonstrate that TCM which regulate autophagy are potential therapeutic candidates for ND treatment.
KW - Autophagy
KW - Neurodegenerative disease
KW - Neuroprotection
KW - Traditional Chinese medicine
UR - https://doi.org/10.1016/j.biopha.2023.114979
UR - http://www.scopus.com/inward/record.url?scp=85096206446&partnerID=8YFLogxK
U2 - 10.1016/j.biopha.2020.110968
DO - 10.1016/j.biopha.2020.110968
M3 - Review article
C2 - 33189067
AN - SCOPUS:85096206446
SN - 0753-3322
VL - 133
JO - Biomedicine and Pharmacotherapy
JF - Biomedicine and Pharmacotherapy
M1 - 110968
ER -