Trace Metals in Traditional Chinese Medicine: A Preliminary Study Using ICP-MS for Metal Determination and As Speciation

Xiaoru Wang; Zhixia Zhuang; Dahai Sun; Jiangxing Hong; Xihong Wu; Frank Sen Chun Lee; Mildred S. Yang; H. W. Leung

Trace Metals in Traditional Chinese Medicine: A Preliminary Study Using ICP-MS for Metal Determination and As Speciation

Xiaoru Wang, Zhixia Zhuang, Dahai Sun, Jiangxing Hong, Xihong Wu, Frank Sen Chun Lee, Mildred S. Yang, H. W. Leung

Research output: Contribution to journal › Journal article › peer-review

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Abstract

The metal content in several TCM drugs was determined by ICP-MS. The efficiencies of different sample digestion methods were compared. Since one of the products studied is known to contain arsenic sulfides as a main ingredient, a solvent fractionation scheme was developed and applied to speciate As in the product. The metal content in the same TCM drug produced by different manufacturers was compared. The concentration of some metals such as Pb and Cd differs widely with different manufacturers, suggesting that their origin is primarily from external contamination. The high sensitivity and precision of the ICP-MS technique offers considerable advantages over conventional ICP-OES techniques for the analysis of complex samples such as TCM materials. Standardized analytic protocols based on ICP-MS are being developed fur the determination and characterization of metals and trace elements in TCM materials for product quality assessment.

Original language	English
Pages (from-to)	86-91
Number of pages	6
Journal	Atomic Spectroscopy
Volume	20
Issue number	3
Publication status	Published - May 1999
Externally published	Yes

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Cite this

@article{767399c3e4434990aff7330dfa8875f0,

title = "Trace Metals in Traditional Chinese Medicine: A Preliminary Study Using ICP-MS for Metal Determination and As Speciation",

abstract = "The metal content in several TCM drugs was determined by ICP-MS. The efficiencies of different sample digestion methods were compared. Since one of the products studied is known to contain arsenic sulfides as a main ingredient, a solvent fractionation scheme was developed and applied to speciate As in the product. The metal content in the same TCM drug produced by different manufacturers was compared. The concentration of some metals such as Pb and Cd differs widely with different manufacturers, suggesting that their origin is primarily from external contamination. The high sensitivity and precision of the ICP-MS technique offers considerable advantages over conventional ICP-OES techniques for the analysis of complex samples such as TCM materials. Standardized analytic protocols based on ICP-MS are being developed fur the determination and characterization of metals and trace elements in TCM materials for product quality assessment.",

author = "Xiaoru Wang and Zhixia Zhuang and Dahai Sun and Jiangxing Hong and Xihong Wu and Lee, {Frank Sen Chun} and Yang, {Mildred S.} and Leung, {H. W.}",

note = "Funding information: The author would like to thank Perkin Elmer LLC for loan of the ICP-MS instrument. The research was supported by the key project of the National Natural Scientific Foundation of China and a research grant for a Visiting Professorship at Hong Kong Baptist University.",

year = "1999",

month = may,

language = "English",

volume = "20",

pages = "86--91",

journal = "Atomic Spectroscopy",

issn = "0195-5373",

publisher = "Atomic Spectroscopy Press Ltd",

number = "3",

}

TY - JOUR

T1 - Trace Metals in Traditional Chinese Medicine

T2 - A Preliminary Study Using ICP-MS for Metal Determination and As Speciation

AU - Wang, Xiaoru

AU - Zhuang, Zhixia

AU - Sun, Dahai

AU - Hong, Jiangxing

AU - Wu, Xihong

AU - Lee, Frank Sen Chun

AU - Yang, Mildred S.

AU - Leung, H. W.

N1 - Funding information: The author would like to thank Perkin Elmer LLC for loan of the ICP-MS instrument. The research was supported by the key project of the National Natural Scientific Foundation of China and a research grant for a Visiting Professorship at Hong Kong Baptist University.

PY - 1999/5

Y1 - 1999/5

N2 - The metal content in several TCM drugs was determined by ICP-MS. The efficiencies of different sample digestion methods were compared. Since one of the products studied is known to contain arsenic sulfides as a main ingredient, a solvent fractionation scheme was developed and applied to speciate As in the product. The metal content in the same TCM drug produced by different manufacturers was compared. The concentration of some metals such as Pb and Cd differs widely with different manufacturers, suggesting that their origin is primarily from external contamination. The high sensitivity and precision of the ICP-MS technique offers considerable advantages over conventional ICP-OES techniques for the analysis of complex samples such as TCM materials. Standardized analytic protocols based on ICP-MS are being developed fur the determination and characterization of metals and trace elements in TCM materials for product quality assessment.

AB - The metal content in several TCM drugs was determined by ICP-MS. The efficiencies of different sample digestion methods were compared. Since one of the products studied is known to contain arsenic sulfides as a main ingredient, a solvent fractionation scheme was developed and applied to speciate As in the product. The metal content in the same TCM drug produced by different manufacturers was compared. The concentration of some metals such as Pb and Cd differs widely with different manufacturers, suggesting that their origin is primarily from external contamination. The high sensitivity and precision of the ICP-MS technique offers considerable advantages over conventional ICP-OES techniques for the analysis of complex samples such as TCM materials. Standardized analytic protocols based on ICP-MS are being developed fur the determination and characterization of metals and trace elements in TCM materials for product quality assessment.

M3 - Journal article

SN - 0195-5373

VL - 20

SP - 86

EP - 91

JO - Atomic Spectroscopy

JF - Atomic Spectroscopy

IS - 3

ER -

Trace Metals in Traditional Chinese Medicine: A Preliminary Study Using ICP-MS for Metal Determination and As Speciation

Abstract

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