Toxicity assessment of nine types of decoction pieces from the daughter root of aconitum carmichaeli (Fuzi) based on the chemical analysis of their diester diterpenoid alkaloids

Guanghua Lu, Zhengqi Dong, Qing Wang, Guangsheng Qian, Wenhua Huang, Zhi Hong JIANG, Kelvin S Y LEUNG, Zhongzhen ZHAO*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

62 Citations (Scopus)

Abstract

Various processed types of Fuzi (the daughter roots of the highly toxic plant Aconitum carmichaeli Debx, FZ) decoction pieces (the herbal materials processed according to the specifications of Chinese medicine manuals; Yinpian in Chinese transliteration) are widely used in traditional medicine to treat various diseases, but their toxicities are not known. Nine types of FZ decoction pieces, including one raw slice and eight processed forms, were therefore prepared, each in 7 to 10 batches, to assess for their toxicity. Altogether 84 FZ samples were quantified on the amount of highly toxic diester diterpenoid alkaloids, i.e., aconitine, mesaconitine and hypaconitine by a newly developed HPLC method with HPLCDAD and LCMS techniques. The comparison of the processed FZ to raw slices of the root showed that the amount of each analyte in the processed FZ was drastically decreased. The sum of the three toxic compounds in the 8 types of processed FZ was only 3.9134.80% of this value in the FZ raw slice. This implies that the toxicity of processed FZ was decreased significantly. The amounts of toxic components in the 8 types of processed FZ varied significantly, often by a power of ten, indicating that the dosage of these herbs, when prescribed for clinical uses, should be cautiously set in order to avoid poisoning incidents.

Original languageEnglish
Pages (from-to)825-830
Number of pages6
JournalPlanta Medica
Volume76
Issue number8
DOIs
Publication statusPublished - 2010

Scopus Subject Areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

User-Defined Keywords

  • Aconitum carmichaeli Debx
  • Daughter root
  • Diester diterpenoid alkaloids
  • Ranunculaceae
  • Toxicity

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