Towards tumour targeting with copper-radiolabelled macrocycle-antibody conjugates

J. Richard Morphy; David Parker; Ritu Kataky; Alice Harrison; Michael A.W. Eaton; Andrew Millican; Alison Phipps; Carole Walker

doi:10.1039/C39890000792

Towards tumour targeting with copper-radiolabelled macrocycle-antibody conjugates

J. Richard Morphy
, David Parker^*
, Ritu Kataky
, Alice Harrison
, Michael A.W. Eaton
, Andrew Millican
, Alison Phipps
, Carole Walker

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

41 Citations (Scopus)

Abstract

Tetra-aza-macrocycles covalently attached to a monoclonal antibody may be efficiently radiolabelled with ⁶⁴Cu or ⁶⁷Cu at pH 4, minimising non-specific binding to the protein, giving a kinetically stable conjugate in vivo.

Original language	English
Pages (from-to)	792-794
Number of pages	3
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	12
DOIs	https://doi.org/10.1039/C39890000792
Publication status	Published - Jun 1989

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10.1039/C39890000792

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@article{66a6350d30fd4f858950f53b87af5cde,

title = "Towards tumour targeting with copper-radiolabelled macrocycle-antibody conjugates",

abstract = "Tetra-aza-macrocycles covalently attached to a monoclonal antibody may be efficiently radiolabelled with 64Cu or 67Cu at pH 4, minimising non-specific binding to the protein, giving a kinetically stable conjugate in vivo.",

author = "Morphy, \{J. Richard\} and David Parker and Ritu Kataky and Alice Harrison and Eaton, \{Michael A.W.\} and Andrew Millican and Alison Phipps and Carole Walker",

year = "1989",

month = jun,

doi = "10.1039/C39890000792",

language = "English",

pages = "792--794",

journal = "Journal of the Chemical Society, Chemical Communications",

issn = "0022-4936",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Towards tumour targeting with copper-radiolabelled macrocycle-antibody conjugates

AU - Morphy, J. Richard

AU - Parker, David

AU - Kataky, Ritu

AU - Harrison, Alice

AU - Eaton, Michael A.W.

AU - Millican, Andrew

AU - Phipps, Alison

AU - Walker, Carole

PY - 1989/6

Y1 - 1989/6

N2 - Tetra-aza-macrocycles covalently attached to a monoclonal antibody may be efficiently radiolabelled with 64Cu or 67Cu at pH 4, minimising non-specific binding to the protein, giving a kinetically stable conjugate in vivo.

AB - Tetra-aza-macrocycles covalently attached to a monoclonal antibody may be efficiently radiolabelled with 64Cu or 67Cu at pH 4, minimising non-specific binding to the protein, giving a kinetically stable conjugate in vivo.

UR - https://www.scopus.com/pages/publications/0024360781

U2 - 10.1039/C39890000792

DO - 10.1039/C39890000792

M3 - Journal article

AN - SCOPUS:0024360781

SN - 0022-4936

SP - 792

EP - 794

JO - Journal of the Chemical Society, Chemical Communications

JF - Journal of the Chemical Society, Chemical Communications

IS - 12

ER -

Towards tumour targeting with copper-radiolabelled macrocycle-antibody conjugates

Abstract

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