Towards tumour imaging with indium-111 labelled macrocycle-antibody conjugates

Andrew S. Craig; Ian M. Helps; Karl J. Jankowski; David Parker; Nigel R. A. Beeley; Byron A. Boyce; Michael A. W. Eaton; Andrew T. Millican; Kenneth Millar; Alison Phipps; Stephen K. Rhind; Alice Harrison; Carole Walker

doi:10.1039/C39890000794

Towards tumour imaging with indium-111 labelled macrocycle-antibody conjugates

Andrew S. Craig
, Ian M. Helps
, Karl J. Jankowski
, David Parker^*
, Nigel R. A. Beeley
, Byron A. Boyce
, Michael A. W. Eaton
, Andrew T. Millican
, Kenneth Millar
, Alison Phipps
, Stephen K. Rhind
, Alice Harrison
, Carole Walker

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

67 Citations (Scopus)

Abstract

C-Functionalised triazacyclododecane and triazacyclononane triacid macrocycles have been covalently attached to a monoclonal antibody and may be labelled with ¹¹¹In to form kinetically inert radiolabelled complexes.

Original language	English
Pages (from-to)	794-796
Number of pages	3
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	12
DOIs	https://doi.org/10.1039/C39890000794
Publication status	Published - 15 Jun 1989

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Craig, A. S., Helps, I. M., Jankowski, K. J., Parker, D., Beeley, N. R. A., Boyce, B. A., Eaton, M. A. W., Millican, A. T., Millar, K., Phipps, A., Rhind, S. K., Harrison, A., & Walker, C. (1989). Towards tumour imaging with indium-111 labelled macrocycle-antibody conjugates. Journal of the Chemical Society, Chemical Communications, (12), 794-796. https://doi.org/10.1039/C39890000794

@article{102c2303595b4a9ebe975de9d5a295d7,

title = "Towards tumour imaging with indium-111 labelled macrocycle-antibody conjugates",

abstract = "C-Functionalised triazacyclododecane and triazacyclononane triacid macrocycles have been covalently attached to a monoclonal antibody and may be labelled with 111In to form kinetically inert radiolabelled complexes.",

author = "Craig, \{Andrew S.\} and Helps, \{Ian M.\} and Jankowski, \{Karl J.\} and David Parker and Beeley, \{Nigel R. A.\} and Boyce, \{Byron A.\} and Eaton, \{Michael A. W.\} and Millican, \{Andrew T.\} and Kenneth Millar and Alison Phipps and Rhind, \{Stephen K.\} and Alice Harrison and Carole Walker",

note = "We thank the S.E.R.C. and the M.R.C. for support, the Royal Society of Chemistry for a Hickinbottom fellowship (D. P.), and Dr. F. A. Smith for PAC spectroscopic measurements. ",

year = "1989",

month = jun,

day = "15",

doi = "10.1039/C39890000794",

language = "English",

pages = "794--796",

journal = "Journal of the Chemical Society, Chemical Communications",

issn = "0022-4936",

publisher = "Royal Society of Chemistry",

number = "12",

}

TY - JOUR

T1 - Towards tumour imaging with indium-111 labelled macrocycle-antibody conjugates

AU - Craig, Andrew S.

AU - Helps, Ian M.

AU - Jankowski, Karl J.

AU - Parker, David

AU - Beeley, Nigel R. A.

AU - Boyce, Byron A.

AU - Eaton, Michael A. W.

AU - Millican, Andrew T.

AU - Millar, Kenneth

AU - Phipps, Alison

AU - Rhind, Stephen K.

AU - Harrison, Alice

AU - Walker, Carole

N1 - We thank the S.E.R.C. and the M.R.C. for support, the Royal Society of Chemistry for a Hickinbottom fellowship (D. P.), and Dr. F. A. Smith for PAC spectroscopic measurements.

PY - 1989/6/15

Y1 - 1989/6/15

N2 - C-Functionalised triazacyclododecane and triazacyclononane triacid macrocycles have been covalently attached to a monoclonal antibody and may be labelled with 111In to form kinetically inert radiolabelled complexes.

AB - C-Functionalised triazacyclododecane and triazacyclononane triacid macrocycles have been covalently attached to a monoclonal antibody and may be labelled with 111In to form kinetically inert radiolabelled complexes.

UR - https://www.scopus.com/pages/publications/0024334638

U2 - 10.1039/C39890000794

DO - 10.1039/C39890000794

M3 - Journal article

AN - SCOPUS:0024334638

SN - 0022-4936

SP - 794

EP - 796

JO - Journal of the Chemical Society, Chemical Communications

JF - Journal of the Chemical Society, Chemical Communications

IS - 12

ER -

Towards tumour imaging with indium-111 labelled macrocycle-antibody conjugates

Abstract

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