Towards structurally responsive synthetic macrocyclic receptors for acetylcholine

David Parker; Mark Rosser

doi:10.1039/p29950000085

Towards structurally responsive synthetic macrocyclic receptors for acetylcholine

David Parker^*
, Mark Rosser

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

7 Citations (Scopus)

Abstract

The synthesis and complexation behaviour of structurally related neutral and ionic cyclophanes is reported. A neutral pyridino-cyclophane selectively mediates transport of acetylcholine while ionic receptors incorporating both a pyridine moiety and a carboxyphenyl group form stronger complexes in aqueous THF as revealed by ¹H NMR spectroscopy. These ionic receptors form 1:1 complexes with the substrate.

Original language	English
Pages (from-to)	85-89
Number of pages	5
Journal	Journal of the Chemical Society, Perkin Transactions 2
Issue number	1
DOIs	https://doi.org/10.1039/p29950000085
Publication status	Published - Jan 1995

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title = "Towards structurally responsive synthetic macrocyclic receptors for acetylcholine",

abstract = "The synthesis and complexation behaviour of structurally related neutral and ionic cyclophanes is reported. A neutral pyridino-cyclophane selectively mediates transport of acetylcholine while ionic receptors incorporating both a pyridine moiety and a carboxyphenyl group form stronger complexes in aqueous THF as revealed by 1H NMR spectroscopy. These ionic receptors form 1:1 complexes with the substrate.",

author = "David Parker and Mark Rosser",

year = "1995",

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AU - Parker, David

AU - Rosser, Mark

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N2 - The synthesis and complexation behaviour of structurally related neutral and ionic cyclophanes is reported. A neutral pyridino-cyclophane selectively mediates transport of acetylcholine while ionic receptors incorporating both a pyridine moiety and a carboxyphenyl group form stronger complexes in aqueous THF as revealed by 1H NMR spectroscopy. These ionic receptors form 1:1 complexes with the substrate.

AB - The synthesis and complexation behaviour of structurally related neutral and ionic cyclophanes is reported. A neutral pyridino-cyclophane selectively mediates transport of acetylcholine while ionic receptors incorporating both a pyridine moiety and a carboxyphenyl group form stronger complexes in aqueous THF as revealed by 1H NMR spectroscopy. These ionic receptors form 1:1 complexes with the substrate.

UR - https://www.scopus.com/pages/publications/0002071242

U2 - 10.1039/p29950000085

DO - 10.1039/p29950000085

M3 - Journal article

AN - SCOPUS:0002071242

SN - 1472-779X

SP - 85

EP - 89

JO - Journal of the Chemical Society, Perkin Transactions 2

JF - Journal of the Chemical Society, Perkin Transactions 2

IS - 1

ER -

Towards structurally responsive synthetic macrocyclic receptors for acetylcholine

Abstract

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