Total synthesis of the L-hexoses

Soo Y. Ko; Albert W M Lee; Satoru Masamune; Lawrence A. Reed III; K. Barry Sharpless; Frederick J. Walker

doi:10.1016/S0040-4020(01)97596-9

Total synthesis of the L-hexoses

Soo Y. Ko^*
, Albert W M Lee
, Satoru Masamune
, Lawrence A. Reed III
, K. Barry Sharpless
, Frederick J. Walker

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

144 Citations (Scopus)

Abstract

Enantiomerically pure polyhydroxylated natural products are synthesized by using a reiterative two-carbon extension cycle consisting of four key transformations. The generality and efficiency of this methodology are demonstrated in the total synthesis of all eight L-hexoses.

Original language	English
Pages (from-to)	245-264
Number of pages	20
Journal	Tetrahedron
Volume	46
Issue number	1
DOIs	https://doi.org/10.1016/S0040-4020(01)97596-9
Publication status	Published - Jan 1990

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@article{9104925424504af0a9de11d108552144,

title = "Total synthesis of the L-hexoses",

abstract = "Enantiomerically pure polyhydroxylated natural products are synthesized by using a reiterative two-carbon extension cycle consisting of four key transformations. The generality and efficiency of this methodology are demonstrated in the total synthesis of all eight L-hexoses.",

author = "Ko, \{Soo Y.\} and Lee, \{Albert W M\} and Satoru Masamune and \{A. Reed III\}, Lawrence and \{Barry Sharpless\}, K. and Walker, \{Frederick J.\}",

note = "Funding Information: ACKNOWLEDGEMENT. We are grateful to the National Institutes of Health (grant GM 31124) and to the National Science Foundation for financial support. High-resolution mass spectra were provided by a facility supported by the National Institutes of Health (grant RR 00317). We are greatly indebted to Drs. Y. Ito, T. Katsuki, P. Ma, V. Martin, D. Tuddenham and S. Viti for their contributions which provided the foundation for the present work.",

year = "1990",

month = jan,

doi = "10.1016/S0040-4020(01)97596-9",

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journal = "Tetrahedron",

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T1 - Total synthesis of the L-hexoses

AU - Ko, Soo Y.

AU - Lee, Albert W M

AU - Masamune, Satoru

AU - A. Reed III, Lawrence

AU - Barry Sharpless, K.

AU - Walker, Frederick J.

N1 - Funding Information: ACKNOWLEDGEMENT. We are grateful to the National Institutes of Health (grant GM 31124) and to the National Science Foundation for financial support. High-resolution mass spectra were provided by a facility supported by the National Institutes of Health (grant RR 00317). We are greatly indebted to Drs. Y. Ito, T. Katsuki, P. Ma, V. Martin, D. Tuddenham and S. Viti for their contributions which provided the foundation for the present work.

PY - 1990/1

Y1 - 1990/1

N2 - Enantiomerically pure polyhydroxylated natural products are synthesized by using a reiterative two-carbon extension cycle consisting of four key transformations. The generality and efficiency of this methodology are demonstrated in the total synthesis of all eight L-hexoses.

AB - Enantiomerically pure polyhydroxylated natural products are synthesized by using a reiterative two-carbon extension cycle consisting of four key transformations. The generality and efficiency of this methodology are demonstrated in the total synthesis of all eight L-hexoses.

UR - https://www.scopus.com/pages/publications/0011054904

U2 - 10.1016/S0040-4020(01)97596-9

DO - 10.1016/S0040-4020(01)97596-9

M3 - Journal article

AN - SCOPUS:0011054904

SN - 0040-4020

VL - 46

SP - 245

EP - 264

JO - Tetrahedron

JF - Tetrahedron

IS - 1

ER -

Total synthesis of the L-hexoses

Abstract

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