@article{142f6c3b6abc4ddca45c904c4e29965a,
title = "Total Synthesis-Enabled Systematic Structure-Activity Relationship Study for Development of a Bioactive Alkyne-Tagged Derivative of Neolaxiflorin L",
abstract = "Neolaxiflorin L (NL) is a low-abundant Isodon 7,20-epoxy-ent-kuarenoid and was found to be a promising anticancer drug candidate in our previous study. In order to study its structure-activity relationship (SAR), a diversity-oriented synthetic route toward two libraries of (±)-NL analogs, including analogs containing different functionalities in the same 7,20-epoxy-ent-kuarene skeleton and analogs with skeletal changes, has been developed. The results of this total synthesis-enabled SAR successfully led to a bioactive alkyne-tagged NL derivative, which could be a useful probe for proteomics studies.",
author = "Mengxun Zhang and Lee, {Magnolia Muk Lan} and Weijian Ye and Wong, {Wing Yan} and Chan, {Brandon Dow} and Sibao Chen and Lizhi Zhu and TAI, {William C S} and LEE, {Chi Sing}",
note = "Funding Information: This work is financially supported by the National Natural Science Foundation of China (grant nos. 21502002, 21572006 21871017 and 81872769), the Natural Science Foundation of Guangdong Province, China (grant no. 2017A030313042), the Hong Kong Research Grants Council General Research Fund (project no. 12103515), the Health and Medical Research Fund (project no. 15161401), the Shenzhen Science and Technology Innovation Committee (grant nos. JCYJ20151030164022389 JCYJ20160229173844278, JCYJ20160428153421635 and JCYJ20160330095659560) Peking University Shenzhen Graduate School, Hong Kong Polytechnic University and Hong Kong Baptist University (RC-SGT2/18-19/SCI/005).",
year = "2019",
month = jun,
day = "7",
doi = "10.1021/acs.joc.9b00748",
language = "English",
volume = "84",
pages = "7007--7016",
journal = "Journal of Organic Chemistry",
issn = "0022-3263",
publisher = "American Chemical Society",
number = "11",
}
