Timosaponin AIII promotes non-small-cell lung cancer ferroptosis through targeting and facilitating HSP90 mediated GPX4 ubiquitination and degradation

Medicine & Life Sciences

• timosaponin AIII 100%
• Phospholipid Hydroperoxide Glutathione Peroxidase 78%
• Ferroptosis 76%
• HSP90 Heat-Shock Proteins 63%
• Ubiquitination 52%
• Non-Small Cell Lung Carcinoma 43%
• Cell Death 10%
• Liver Neoplasms 6%
• Malondialdehyde 6%
• ferrostatin-1 6%
• Iron 5%
• Reactive Oxygen Species 5%
• tanespimycin 5%
• Cell Proliferation 4%
• Breast Neoplasms 4%
• Surface Plasmon Resonance 4%
• Saponins 4%
• G2 Phase 3%
• Immunoprecipitation 3%
• Cell Division 3%
• Nude Mice 3%
• Glutathione 3%
• Heterografts 3%
• Transfection 2%
• Small Interfering RNA 2%
• Cell Movement 2%
• Lung Neoplasms 2%
• Steroids 2%
• Neoplasms 2%
• Cell Line 2%
• Growth 1%
• In Vitro Techniques 1%

Agriculture & Biology

• phospholipid-hydroperoxide glutathione peroxidase 74%
• heat-shock protein 90 66%
• lung neoplasms 62%
• ubiquitination 60%
• degradation 29%
• cell death 19%
• cells 15%
• neoplasms 12%
• malondialdehyde 9%
• cell proliferation 9%
• reactive oxygen species 8%
• iron 7%
• surface plasmon resonance 7%
• steroid saponins 7%
• liver neoplasms 7%
• breast neoplasms 6%
• transfection 5%
• cell movement 5%
• assays 5%
• mitosis 5%
• neoplasm cells 4%
• glutathione 4%
• cell lines 3%
• mice 3%

Earth & Environmental Sciences

• heat shock 69%
• targeting 47%
• cancer 45%
• protein 34%
• degradation 31%
• cell 29%
• reactive oxygen species 11%
• tumor 10%
• inhibitor 8%
• in vitro assay 7%
• iron 6%
• steroid 5%
• assay 4%
• effect 2%
• analysis 1%