TY - JOUR
T1 - Tibetan Medicine for Diabetes Mellitus: Overview of Pharmacological Perspectives
T2 - Overview of Pharmacological Perspectives
AU - Yan, Li Shan
AU - Cheng, Brian Chi Yan
AU - Zhang, Shuo Feng
AU - Luo, Gan
AU - Zhang, Chao
AU - Wang, Qing Gao
AU - Fu, Xiu Qiong
AU - Wang, Yi Wei
AU - Zhang, Yi
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China (Grant Number 81803793 and 82003957) and the Young Scientist Program by Beijing University of Chinese Medicine.
Publisher Copyright:
Copyright © 2021 Yan, Cheng, Zhang, Luo, Zhang, Wang, Fu, Wang and Zhang.
PY - 2021/10/21
Y1 - 2021/10/21
N2 - Diabetes mellitus (DM) and its complications pose a major public health threat which is approaching epidemic proportions globally. Current drug options may not provide good efficacy and even cause serious adverse effects. Seeking safe and effective agents for DM treatment has been an area of intensive interest. As a healing system originating in Tibet, Traditional Tibetan Medicine (TTM) has been widely used by Tibetan people for the prevention and treatment of DM and its complications for hundreds of years. Tibetan Materia Medica (TMM) including the flower of Edgeworthia gardneri (Wall.) Meisn., Phyllanthi Fructus, Chebulae Fructus, Huidouba, and Berberidis Cortex are most frequently used and studied. These TMMs possess hypoglycemic, anti-insulin resistant, anti-glycation, lipid lowering, anti-inflammatory, and anti-oxidative effects. The underlying mechanisms of these actions may be related to their α-glucosidase inhibitory, insulin signaling promoting, PPARs-activating, gut microbiota modulation, islet β cell-preserving, and TNF-α signaling suppressive properties. This review presents a comprehensive overview of the mode and mechanisms of action of various active constituents, extracts, preparations, and formulas from TMM. The dynamic beneficial effects of the products prepared from TMM for the management of DM and its complications are summarized. These TMMs are valuable materia medica which have the potential to be developed as safe and effective anti-DM agents.
AB - Diabetes mellitus (DM) and its complications pose a major public health threat which is approaching epidemic proportions globally. Current drug options may not provide good efficacy and even cause serious adverse effects. Seeking safe and effective agents for DM treatment has been an area of intensive interest. As a healing system originating in Tibet, Traditional Tibetan Medicine (TTM) has been widely used by Tibetan people for the prevention and treatment of DM and its complications for hundreds of years. Tibetan Materia Medica (TMM) including the flower of Edgeworthia gardneri (Wall.) Meisn., Phyllanthi Fructus, Chebulae Fructus, Huidouba, and Berberidis Cortex are most frequently used and studied. These TMMs possess hypoglycemic, anti-insulin resistant, anti-glycation, lipid lowering, anti-inflammatory, and anti-oxidative effects. The underlying mechanisms of these actions may be related to their α-glucosidase inhibitory, insulin signaling promoting, PPARs-activating, gut microbiota modulation, islet β cell-preserving, and TNF-α signaling suppressive properties. This review presents a comprehensive overview of the mode and mechanisms of action of various active constituents, extracts, preparations, and formulas from TMM. The dynamic beneficial effects of the products prepared from TMM for the management of DM and its complications are summarized. These TMMs are valuable materia medica which have the potential to be developed as safe and effective anti-DM agents.
KW - diabetes mellitus
KW - diabetic complications
KW - insulin resistance
KW - pharmacology
KW - tibetan material medica
UR - http://www.scopus.com/inward/record.url?scp=85118646271&partnerID=8YFLogxK
U2 - 10.3389/fphar.2021.748500
DO - 10.3389/fphar.2021.748500
M3 - Review article
AN - SCOPUS:85118646271
SN - 1663-9812
VL - 12
JO - Frontiers in Pharmacology
JF - Frontiers in Pharmacology
M1 - 748500
ER -
