Tianma Gouteng Yin, a Traditional Chinese Medicine decoction, exerts neuroprotective effects in animal and cellular models of Parkinson's disease

Liangfeng Liu; Juxian Song; Jia Hong Lu; Ying Yu Huang; Yu Zeng; Lei Lei Chen; S S Kumar Durairajan; Simon Q B Han; Min Li

doi:10.1038/srep16862

Tianma Gouteng Yin, a Traditional Chinese Medicine decoction, exerts neuroprotective effects in animal and cellular models of Parkinson's disease

Liangfeng Liu, Juxian Song, Jia Hong Lu, Ying Yu Huang, Yu Zeng, Lei Lei Chen, S S Kumar Durairajan, Simon Q B Han, Min Li^*

^*Corresponding author for this work

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Abstract

Tianma Gouteng Yin (TGY) is a traditional Chinese medicine (TCM) decoction widely used to treat symptoms associated with typical Parkinson's disease (PD). In this study, the neuroprotective effects of water extract of TGY were tested on rotenone-intoxicated and human α-synuclein transgenic Drosophila PD models. In addition, the neuroprotective effect of TGY was also evaluated in the human dopaminergic neuroblastoma SH-SY5Y cell line treated with rotenone and the rotenone intoxicated hemi-parkinsonian rats. In rotenone-induced PD models, TGY improved survival rate, alleviated impaired locomotor function of Drosophila, mitigated the loss of dopaminergic neurons in hemi-parkinsonian rats and alleviated apoptotic cell death in SH-SY5Y cells; in α-synuclein transgenic Drosophila, TGY reduced the level of α-synuclein and prevented degeneration of dopaminergic neurons. Conclusively, TGY is neuroprotective in PD models both in vivo and in vitro.

Original language	English
Article number	16862
Number of pages	11
Journal	Scientific Reports
Volume	5
DOIs	https://doi.org/10.1038/srep16862
Publication status	Published - 18 Nov 2015

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title = "Tianma Gouteng Yin, a Traditional Chinese Medicine decoction, exerts neuroprotective effects in animal and cellular models of Parkinson's disease",

abstract = "Tianma Gouteng Yin (TGY) is a traditional Chinese medicine (TCM) decoction widely used to treat symptoms associated with typical Parkinson's disease (PD). In this study, the neuroprotective effects of water extract of TGY were tested on rotenone-intoxicated and human α-synuclein transgenic Drosophila PD models. In addition, the neuroprotective effect of TGY was also evaluated in the human dopaminergic neuroblastoma SH-SY5Y cell line treated with rotenone and the rotenone intoxicated hemi-parkinsonian rats. In rotenone-induced PD models, TGY improved survival rate, alleviated impaired locomotor function of Drosophila, mitigated the loss of dopaminergic neurons in hemi-parkinsonian rats and alleviated apoptotic cell death in SH-SY5Y cells; in α-synuclein transgenic Drosophila, TGY reduced the level of α-synuclein and prevented degeneration of dopaminergic neurons. Conclusively, TGY is neuroprotective in PD models both in vivo and in vitro.",

author = "Liangfeng Liu and Juxian Song and Lu, {Jia Hong} and Huang, {Ying Yu} and Yu Zeng and Chen, {Lei Lei} and Durairajan, {S S Kumar} and Han, {Simon Q B} and Min Li",

note = "Funding Information: This work was supported by the General Research Fund of Hong Kong Government (RGC/HKBU-121009/14 ), the Health and Medical Research Fund from Food and Health Bureau of Hong Kong Government (HMRF 12132091), the Innovation and Technology Fund (ITF) of Hong Kong Government (ITS/274/12), the Interdisciplinary Research Matching Scheme (IRMS) (IRMS/12-13/1A), and the Matching Proof-of-Concept Fund (MPCF 04-12/13 and MPCF-008-2014/2015) of Hong Kong Baptist University. The authors would like to thank Dr. Martha Dahlen for her English editing of this manuscript.",

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AU - Liu, Liangfeng

AU - Song, Juxian

AU - Lu, Jia Hong

AU - Huang, Ying Yu

AU - Zeng, Yu

AU - Chen, Lei Lei

AU - Durairajan, S S Kumar

AU - Han, Simon Q B

AU - Li, Min

N1 - Funding Information: This work was supported by the General Research Fund of Hong Kong Government (RGC/HKBU-121009/14 ), the Health and Medical Research Fund from Food and Health Bureau of Hong Kong Government (HMRF 12132091), the Innovation and Technology Fund (ITF) of Hong Kong Government (ITS/274/12), the Interdisciplinary Research Matching Scheme (IRMS) (IRMS/12-13/1A), and the Matching Proof-of-Concept Fund (MPCF 04-12/13 and MPCF-008-2014/2015) of Hong Kong Baptist University. The authors would like to thank Dr. Martha Dahlen for her English editing of this manuscript.

PY - 2015/11/18

Y1 - 2015/11/18

N2 - Tianma Gouteng Yin (TGY) is a traditional Chinese medicine (TCM) decoction widely used to treat symptoms associated with typical Parkinson's disease (PD). In this study, the neuroprotective effects of water extract of TGY were tested on rotenone-intoxicated and human α-synuclein transgenic Drosophila PD models. In addition, the neuroprotective effect of TGY was also evaluated in the human dopaminergic neuroblastoma SH-SY5Y cell line treated with rotenone and the rotenone intoxicated hemi-parkinsonian rats. In rotenone-induced PD models, TGY improved survival rate, alleviated impaired locomotor function of Drosophila, mitigated the loss of dopaminergic neurons in hemi-parkinsonian rats and alleviated apoptotic cell death in SH-SY5Y cells; in α-synuclein transgenic Drosophila, TGY reduced the level of α-synuclein and prevented degeneration of dopaminergic neurons. Conclusively, TGY is neuroprotective in PD models both in vivo and in vitro.

AB - Tianma Gouteng Yin (TGY) is a traditional Chinese medicine (TCM) decoction widely used to treat symptoms associated with typical Parkinson's disease (PD). In this study, the neuroprotective effects of water extract of TGY were tested on rotenone-intoxicated and human α-synuclein transgenic Drosophila PD models. In addition, the neuroprotective effect of TGY was also evaluated in the human dopaminergic neuroblastoma SH-SY5Y cell line treated with rotenone and the rotenone intoxicated hemi-parkinsonian rats. In rotenone-induced PD models, TGY improved survival rate, alleviated impaired locomotor function of Drosophila, mitigated the loss of dopaminergic neurons in hemi-parkinsonian rats and alleviated apoptotic cell death in SH-SY5Y cells; in α-synuclein transgenic Drosophila, TGY reduced the level of α-synuclein and prevented degeneration of dopaminergic neurons. Conclusively, TGY is neuroprotective in PD models both in vivo and in vitro.

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Tianma Gouteng Yin, a Traditional Chinese Medicine decoction, exerts neuroprotective effects in animal and cellular models of Parkinson's disease

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