TY - JOUR
T1 - Thymoquinone and its pharmacological perspective
T2 - A review
AU - Tabassum, Shabana
AU - Rosli, Norhayati
AU - Ichwan, Solachuddin Jauhari Arief
AU - Mishra, Puranjan
N1 - Publisher Copyright:
© 2021 The Author(s)
PY - 2021/12
Y1 - 2021/12
N2 - Thymoquinone (TQ) a plant-derived dietary of Nigella sativa, is a well-known traditionally and clinically used natural medicine. The diverse pharmacological properties of TQ have been identified including antimicrobial, antihistamine, antioxidant effects, immunomodulator, and anticancer activities. In this review, investigations regarding the effects of TQ in oxidative stress, immunomodulation, and various type of cancer have been reviewed based on the available relevant literature. TQ-based induction of the immune system by modulating different inflammatory mediators i.e., cytokines, leukins, interleukins, interferons, and other immune cells have been reviewed here. Several studies signified remarkable anticancer potentials of TQ depending upon its concentration and type of cancer cell. Conclusively, understanding pharmacological activities of TQ its molecular mechanism could help researchers to develop a potent analog of well-established chemotherapeutic drugs in clinical trials.
AB - Thymoquinone (TQ) a plant-derived dietary of Nigella sativa, is a well-known traditionally and clinically used natural medicine. The diverse pharmacological properties of TQ have been identified including antimicrobial, antihistamine, antioxidant effects, immunomodulator, and anticancer activities. In this review, investigations regarding the effects of TQ in oxidative stress, immunomodulation, and various type of cancer have been reviewed based on the available relevant literature. TQ-based induction of the immune system by modulating different inflammatory mediators i.e., cytokines, leukins, interleukins, interferons, and other immune cells have been reviewed here. Several studies signified remarkable anticancer potentials of TQ depending upon its concentration and type of cancer cell. Conclusively, understanding pharmacological activities of TQ its molecular mechanism could help researchers to develop a potent analog of well-established chemotherapeutic drugs in clinical trials.
KW - Anticancer
KW - Antioxidant
KW - Immunomodulatory
KW - Nigella sativa
KW - Thymoquinone
UR - http://www.scopus.com/inward/record.url?scp=85131538119&partnerID=8YFLogxK
U2 - 10.1016/j.prmcm.2021.100020
DO - 10.1016/j.prmcm.2021.100020
M3 - Journal article
AN - SCOPUS:85131538119
SN - 2667-1425
VL - 1
JO - Pharmacological Research - Modern Chinese Medicine
JF - Pharmacological Research - Modern Chinese Medicine
M1 - 100020
ER -
