Three New Ent-Kauranoids from Isodon Phyllostachys

Xian Li; Jianxin Pu; Shenghong Li; Shengxiong Huang; Zhiying Weng; Quanbin Han; Handong Sun

doi:10.3987/COM-07-11140

Three New Ent-Kauranoids from Isodon Phyllostachys

Xian Li^*, Jianxin Pu, Shenghong Li, Shengxiong Huang, Zhiying Weng, Quanbin Han, Handong Sun^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

5 Citations (Scopus)

Abstract

Three new ent-kaurane diterpenoids, phyllostacins C-E (1-3), together with six known analogues, oridonin (4), ponicidin (5), effusanin A (6), rabdoternin E (7), rabdoternin F (8), and macrocalyxoformin E (9), were isolated from the aerial parts of Isodon phyllostachys. The structures of compounds (1-3) were determined on the basis of spectroscopic methods including extensive 1D and 2D NMR analysis. All compounds were evaluated for their inhibitory activity against K562, HL60 and HepG2 (hepatoma) cell lines.

Original language	English
Pages (from-to)	2441-2447
Number of pages	7
Journal	Heterocycles
Volume	71
Issue number	11
Early online date	8 Aug 2007
DOIs	https://doi.org/10.3987/COM-07-11140
Publication status	Published - 1 Nov 2007

Scopus Subject Areas

Analytical Chemistry
Pharmacology
Organic Chemistry

User-Defined Keywords

Biological Activity
Diterpenoid
ent-Kaurane
Isodon phyllostachys
Phyllostacins C-E

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10.3987/COM-07-11140

Cite this

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title = "Three New Ent-Kauranoids from Isodon Phyllostachys",

abstract = "Three new ent-kaurane diterpenoids, phyllostacins C-E (1-3), together with six known analogues, oridonin (4), ponicidin (5), effusanin A (6), rabdoternin E (7), rabdoternin F (8), and macrocalyxoformin E (9), were isolated from the aerial parts of Isodon phyllostachys. The structures of compounds (1-3) were determined on the basis of spectroscopic methods including extensive 1D and 2D NMR analysis. All compounds were evaluated for their inhibitory activity against K562, HL60 and HepG2 (hepatoma) cell lines.",

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language = "English",

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T1 - Three New Ent-Kauranoids from Isodon Phyllostachys

AU - Li, Xian

AU - Pu, Jianxin

AU - Li, Shenghong

AU - Huang, Shengxiong

AU - Weng, Zhiying

AU - Han, Quanbin

AU - Sun, Handong

PY - 2007/11/1

Y1 - 2007/11/1

N2 - Three new ent-kaurane diterpenoids, phyllostacins C-E (1-3), together with six known analogues, oridonin (4), ponicidin (5), effusanin A (6), rabdoternin E (7), rabdoternin F (8), and macrocalyxoformin E (9), were isolated from the aerial parts of Isodon phyllostachys. The structures of compounds (1-3) were determined on the basis of spectroscopic methods including extensive 1D and 2D NMR analysis. All compounds were evaluated for their inhibitory activity against K562, HL60 and HepG2 (hepatoma) cell lines.

AB - Three new ent-kaurane diterpenoids, phyllostacins C-E (1-3), together with six known analogues, oridonin (4), ponicidin (5), effusanin A (6), rabdoternin E (7), rabdoternin F (8), and macrocalyxoformin E (9), were isolated from the aerial parts of Isodon phyllostachys. The structures of compounds (1-3) were determined on the basis of spectroscopic methods including extensive 1D and 2D NMR analysis. All compounds were evaluated for their inhibitory activity against K562, HL60 and HepG2 (hepatoma) cell lines.

KW - Biological Activity

KW - Diterpenoid

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U2 - 10.3987/COM-07-11140

DO - 10.3987/COM-07-11140

M3 - Journal article

SN - 0385-5414

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JO - Heterocycles

JF - Heterocycles

IS - 11

ER -

Three New Ent-Kauranoids from Isodon Phyllostachys

Abstract

Scopus Subject Areas

User-Defined Keywords

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