TY - JOUR
T1 - Thin, soft, wearable system for continuous wireless monitoring of artery blood pressure
AU - Li, Jian
AU - Jia, Huiling
AU - Zhou, Jingkun
AU - Huang, Xingcan
AU - Xu, Long
AU - Jia, Shengxin
AU - Gao, Zhan
AU - Yao, Kuanming
AU - Li, Dengfeng
AU - Zhang, Binbin
AU - Liu, Yiming
AU - Huang, Ya
AU - Hu, Yue
AU - Zhao, Guangyao
AU - Xu, Zitong
AU - Li, Jiyu
AU - Yiu, Chun Ki
AU - Gao, Yuyu
AU - Wu, Mengge
AU - Jiao, Yanli
AU - Zhang, Qiang
AU - Tai, Xuecheng
AU - Chan, Raymond H.
AU - Zhang, Yuanting
AU - Ma, Xiaohui
AU - Yu, Xinge
N1 - Funding Information:
This work was supported by InnoHK Project on Project 2.2—AI-based 3D ultrasound imaging algorithm at Hong Kong Centre for Cerebro-Cardiovascular Health Engineering (COCHE), City University of Hong Kong (Grants No. 9667221, 924007 and 9680322), and National Natural Science Foundation of China (Grants No. 62122002).
Publisher Copyright:
© The Author(s) 2023
PY - 2023/12
Y1 - 2023/12
N2 - Continuous monitoring of arterial blood pressure (BP) outside of a clinical setting is crucial for preventing and diagnosing hypertension related diseases. However, current continuous BP monitoring instruments suffer from either bulky systems or poor user-device interfacial performance, hampering their applications in continuous BP monitoring. Here, we report a thin, soft, miniaturized system (TSMS) that combines a conformal piezoelectric sensor array, an active pressure adaptation unit, a signal processing module, and an advanced machine learning method, to allow real wearable, continuous wireless monitoring of ambulatory artery BP. By optimizing the materials selection, control/sampling strategy, and system integration, the TSMS exhibits improved interfacial performance while maintaining Grade A level measurement accuracy. Initial trials on 87 volunteers and clinical tracking of two hypertension individuals prove the capability of the TSMS as a reliable BP measurement product, and its feasibility and practical usability in precise BP control and personalized diagnosis schemes development.
AB - Continuous monitoring of arterial blood pressure (BP) outside of a clinical setting is crucial for preventing and diagnosing hypertension related diseases. However, current continuous BP monitoring instruments suffer from either bulky systems or poor user-device interfacial performance, hampering their applications in continuous BP monitoring. Here, we report a thin, soft, miniaturized system (TSMS) that combines a conformal piezoelectric sensor array, an active pressure adaptation unit, a signal processing module, and an advanced machine learning method, to allow real wearable, continuous wireless monitoring of ambulatory artery BP. By optimizing the materials selection, control/sampling strategy, and system integration, the TSMS exhibits improved interfacial performance while maintaining Grade A level measurement accuracy. Initial trials on 87 volunteers and clinical tracking of two hypertension individuals prove the capability of the TSMS as a reliable BP measurement product, and its feasibility and practical usability in precise BP control and personalized diagnosis schemes development.
UR - http://www.scopus.com/inward/record.url?scp=85168291052&partnerID=8YFLogxK
U2 - 10.1038/s41467-023-40763-3
DO - 10.1038/s41467-023-40763-3
M3 - Journal article
C2 - 37591881
AN - SCOPUS:85168291052
SN - 2041-1723
VL - 14
JO - Nature Communications
JF - Nature Communications
M1 - 5009
ER -
