Thickness-controllable synthesis of metal-organic framework based hollow nanoflowers with magnetic core via liquid phase epitaxy for phosphopeptides enrichment

Ning Zhang; Mengjie Qin; Jiawen Zhu; Xuejing Lou; Xiao Tian; Wende Ma; Youmei Wang; Minghua Lu; Zongwei Cai

doi:10.1016/j.cclet.2024.110177

Thickness-controllable synthesis of metal-organic framework based hollow nanoflowers with magnetic core via liquid phase epitaxy for phosphopeptides enrichment

Ning Zhang^*
, Mengjie Qin
, Jiawen Zhu
, Xuejing Lou
, Xiao Tian
, Wende Ma
, Youmei Wang
, Minghua Lu^*
, Zongwei Cai^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

5 Citations (Scopus)

Abstract

A thickness-controllable method for preparing metal-organic framework hollow nanoflowers on magnetic cores (Fe₃O₄@MOFs HFs) was demonstrated for the first time. The petal of magnetic core with hollow nanoflower structure served as medium for assembling UiO-66-NH₂ shell with different thickness. To further improve its performance, Zr⁴⁺ was immobilized on the surface of Fe₃O₄@UiO-66-NH₂. Compared with conventional Fe₃O₄@UiO-66-NH₂-Zr⁴⁺ nanospheres, the Fe₃O₄@UiO-66-NH₂-Zr⁴⁺ HFs showed increased enrichment performance for phosphopeptides. The Fe₃O₄@UiO-66-NH₂-Zr⁴⁺ HFs served as an attractive restricted-access adsorption material exhibited good selectivity (m_β_-casein:m_BSA=1:1000), high sensitivity (1.0 fmol) and excellent size-exclusion effect (m_β_{-casein digests}:m_BSA=1:200). Furthermore, the Fe₃O₄@UiO-66-NH₂-Zr⁴⁺ HFs was successfully applied to the specific capture of ultratrace phosphopeptide from complex biological samples, revealing the great potential for the identification and analysis of trace phosphopeptides in clinical analysis. This work can be easily extended to the fabrication of diverse mag-MOF HFs with multifunctional and easy to post-modify properties, and open up a new avenue for the design and construction of new MOFs material.

Original language	English
Article number	110177
Number of pages	5
Journal	Chinese Chemical Letters
Volume	36
Issue number	4
DOIs	https://doi.org/10.1016/j.cclet.2024.110177
Publication status	Published - Apr 2025

User-Defined Keywords

Metal-organic framework
Nanoflower
Phosphopeptide
Saliva
Serum

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cclet.2024.110177

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@article{4c301317c50348608624dd72f31f2008,

title = "Thickness-controllable synthesis of metal-organic framework based hollow nanoflowers with magnetic core via liquid phase epitaxy for phosphopeptides enrichment",

abstract = "A thickness-controllable method for preparing metal-organic framework hollow nanoflowers on magnetic cores (Fe3O4@MOFs HFs) was demonstrated for the first time. The petal of magnetic core with hollow nanoflower structure served as medium for assembling UiO-66-NH2 shell with different thickness. To further improve its performance, Zr4+ was immobilized on the surface of Fe3O4@UiO-66-NH2. Compared with conventional Fe3O4@UiO-66-NH2-Zr4+ nanospheres, the Fe3O4@UiO-66-NH2-Zr4+ HFs showed increased enrichment performance for phosphopeptides. The Fe3O4@UiO-66-NH2-Zr4+ HFs served as an attractive restricted-access adsorption material exhibited good selectivity (mβ-casein:mBSA=1:1000), high sensitivity (1.0 fmol) and excellent size-exclusion effect (mβ-casein digests:mBSA=1:200). Furthermore, the Fe3O4@UiO-66-NH2-Zr4+ HFs was successfully applied to the specific capture of ultratrace phosphopeptide from complex biological samples, revealing the great potential for the identification and analysis of trace phosphopeptides in clinical analysis. This work can be easily extended to the fabrication of diverse mag-MOF HFs with multifunctional and easy to post-modify properties, and open up a new avenue for the design and construction of new MOFs material.",

keywords = "Metal-organic framework, Nanoflower, Phosphopeptide, Saliva, Serum",

author = "Ning Zhang and Mengjie Qin and Jiawen Zhu and Xuejing Lou and Xiao Tian and Wende Ma and Youmei Wang and Minghua Lu and Zongwei Cai",

note = "This work was sponsored by the National Natural Science Foundation of China (Nos. 22106038, 22204171 and 22076038), the Henan Provincial Science and Technology Research Project (No. 232102310112), the China Postdoctoral Science Foundation (No. 2022M713299), Natural Science Foundation of Henan Province, China (No. 20230 0410 044), Henan key scientific research programs to Universities and Colleges (No. 22ZX003). Publisher Copyright: {\textcopyright} 2025 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.",

year = "2025",

month = apr,

doi = "10.1016/j.cclet.2024.110177",

language = "English",

volume = "36",

journal = "Chinese Chemical Letters",

issn = "1001-8417",

publisher = "Elsevier B.V.",

number = "4",

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TY - JOUR

T1 - Thickness-controllable synthesis of metal-organic framework based hollow nanoflowers with magnetic core via liquid phase epitaxy for phosphopeptides enrichment

AU - Zhang, Ning

AU - Qin, Mengjie

AU - Zhu, Jiawen

AU - Lou, Xuejing

AU - Tian, Xiao

AU - Ma, Wende

AU - Wang, Youmei

AU - Lu, Minghua

AU - Cai, Zongwei

N1 - This work was sponsored by the National Natural Science Foundation of China (Nos. 22106038, 22204171 and 22076038), the Henan Provincial Science and Technology Research Project (No. 232102310112), the China Postdoctoral Science Foundation (No. 2022M713299), Natural Science Foundation of Henan Province, China (No. 20230 0410 044), Henan key scientific research programs to Universities and Colleges (No. 22ZX003). Publisher Copyright: © 2025 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

PY - 2025/4

Y1 - 2025/4

N2 - A thickness-controllable method for preparing metal-organic framework hollow nanoflowers on magnetic cores (Fe3O4@MOFs HFs) was demonstrated for the first time. The petal of magnetic core with hollow nanoflower structure served as medium for assembling UiO-66-NH2 shell with different thickness. To further improve its performance, Zr4+ was immobilized on the surface of Fe3O4@UiO-66-NH2. Compared with conventional Fe3O4@UiO-66-NH2-Zr4+ nanospheres, the Fe3O4@UiO-66-NH2-Zr4+ HFs showed increased enrichment performance for phosphopeptides. The Fe3O4@UiO-66-NH2-Zr4+ HFs served as an attractive restricted-access adsorption material exhibited good selectivity (mβ-casein:mBSA=1:1000), high sensitivity (1.0 fmol) and excellent size-exclusion effect (mβ-casein digests:mBSA=1:200). Furthermore, the Fe3O4@UiO-66-NH2-Zr4+ HFs was successfully applied to the specific capture of ultratrace phosphopeptide from complex biological samples, revealing the great potential for the identification and analysis of trace phosphopeptides in clinical analysis. This work can be easily extended to the fabrication of diverse mag-MOF HFs with multifunctional and easy to post-modify properties, and open up a new avenue for the design and construction of new MOFs material.

AB - A thickness-controllable method for preparing metal-organic framework hollow nanoflowers on magnetic cores (Fe3O4@MOFs HFs) was demonstrated for the first time. The petal of magnetic core with hollow nanoflower structure served as medium for assembling UiO-66-NH2 shell with different thickness. To further improve its performance, Zr4+ was immobilized on the surface of Fe3O4@UiO-66-NH2. Compared with conventional Fe3O4@UiO-66-NH2-Zr4+ nanospheres, the Fe3O4@UiO-66-NH2-Zr4+ HFs showed increased enrichment performance for phosphopeptides. The Fe3O4@UiO-66-NH2-Zr4+ HFs served as an attractive restricted-access adsorption material exhibited good selectivity (mβ-casein:mBSA=1:1000), high sensitivity (1.0 fmol) and excellent size-exclusion effect (mβ-casein digests:mBSA=1:200). Furthermore, the Fe3O4@UiO-66-NH2-Zr4+ HFs was successfully applied to the specific capture of ultratrace phosphopeptide from complex biological samples, revealing the great potential for the identification and analysis of trace phosphopeptides in clinical analysis. This work can be easily extended to the fabrication of diverse mag-MOF HFs with multifunctional and easy to post-modify properties, and open up a new avenue for the design and construction of new MOFs material.

KW - Metal-organic framework

KW - Nanoflower

KW - Phosphopeptide

KW - Saliva

KW - Serum

UR - https://www.scopus.com/pages/publications/85205307683

UR - https://www.sciencedirect.com/science/article/pii/S100184172400696X?via%3Dihub

U2 - 10.1016/j.cclet.2024.110177

DO - 10.1016/j.cclet.2024.110177

M3 - Journal article

AN - SCOPUS:85205307683

SN - 1001-8417

VL - 36

JO - Chinese Chemical Letters

JF - Chinese Chemical Letters

IS - 4

M1 - 110177

ER -

Thickness-controllable synthesis of metal-organic framework based hollow nanoflowers with magnetic core via liquid phase epitaxy for phosphopeptides enrichment

Abstract

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