TY - JOUR
T1 - Thickness-controllable synthesis of metal-organic framework based hollow nanoflowers with magnetic core via liquid phase epitaxy for phosphopeptides enrichment
AU - Zhang, Ning
AU - Qin, Mengjie
AU - Zhu, Jiawen
AU - Lou, Xuejing
AU - Tian, Xiao
AU - Ma, Wende
AU - Wang, Youmei
AU - Lu, Minghua
AU - Cai, Zongwei
N1 - This work was sponsored by the National Natural Science Foundation of China (Nos. 22106038, 22204171 and 22076038), the Henan Provincial Science and Technology Research Project (No. 232102310112), the China Postdoctoral Science Foundation (No. 2022M713299), Natural Science Foundation of Henan Province, China (No. 20230 0410 044), Henan key scientific research programs to Universities and Colleges (No. 22ZX003).
Publisher Copyright:
© 2025 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
PY - 2025/4
Y1 - 2025/4
N2 - A thickness-controllable method for preparing metal-organic framework hollow nanoflowers on magnetic cores (Fe3O4@MOFs HFs) was demonstrated for the first time. The petal of magnetic core with hollow nanoflower structure served as medium for assembling UiO-66-NH2 shell with different thickness. To further improve its performance, Zr4+ was immobilized on the surface of Fe3O4@UiO-66-NH2. Compared with conventional Fe3O4@UiO-66-NH2-Zr4+ nanospheres, the Fe3O4@UiO-66-NH2-Zr4+ HFs showed increased enrichment performance for phosphopeptides. The Fe3O4@UiO-66-NH2-Zr4+ HFs served as an attractive restricted-access adsorption material exhibited good selectivity (mβ-casein:mBSA=1:1000), high sensitivity (1.0 fmol) and excellent size-exclusion effect (mβ-casein digests:mBSA=1:200). Furthermore, the Fe3O4@UiO-66-NH2-Zr4+ HFs was successfully applied to the specific capture of ultratrace phosphopeptide from complex biological samples, revealing the great potential for the identification and analysis of trace phosphopeptides in clinical analysis. This work can be easily extended to the fabrication of diverse mag-MOF HFs with multifunctional and easy to post-modify properties, and open up a new avenue for the design and construction of new MOFs material.
AB - A thickness-controllable method for preparing metal-organic framework hollow nanoflowers on magnetic cores (Fe3O4@MOFs HFs) was demonstrated for the first time. The petal of magnetic core with hollow nanoflower structure served as medium for assembling UiO-66-NH2 shell with different thickness. To further improve its performance, Zr4+ was immobilized on the surface of Fe3O4@UiO-66-NH2. Compared with conventional Fe3O4@UiO-66-NH2-Zr4+ nanospheres, the Fe3O4@UiO-66-NH2-Zr4+ HFs showed increased enrichment performance for phosphopeptides. The Fe3O4@UiO-66-NH2-Zr4+ HFs served as an attractive restricted-access adsorption material exhibited good selectivity (mβ-casein:mBSA=1:1000), high sensitivity (1.0 fmol) and excellent size-exclusion effect (mβ-casein digests:mBSA=1:200). Furthermore, the Fe3O4@UiO-66-NH2-Zr4+ HFs was successfully applied to the specific capture of ultratrace phosphopeptide from complex biological samples, revealing the great potential for the identification and analysis of trace phosphopeptides in clinical analysis. This work can be easily extended to the fabrication of diverse mag-MOF HFs with multifunctional and easy to post-modify properties, and open up a new avenue for the design and construction of new MOFs material.
KW - Metal-organic framework
KW - Nanoflower
KW - Phosphopeptide
KW - Saliva
KW - Serum
UR - http://www.scopus.com/inward/record.url?scp=85205307683&partnerID=8YFLogxK
UR - https://www.sciencedirect.com/science/article/pii/S100184172400696X?via%3Dihub
U2 - 10.1016/j.cclet.2024.110177
DO - 10.1016/j.cclet.2024.110177
M3 - Journal article
AN - SCOPUS:85205307683
SN - 1001-8417
VL - 36
JO - Chinese Chemical Letters
JF - Chinese Chemical Letters
IS - 4
M1 - 110177
ER -
