Therapeutic potential of flavonoids from traditional Chinese medicine in pancreatic cancer treatment

Qi Wan, Qing Ren, Shuangying Qiao, Aiping Lyu, Xingwei He*, Fangfei Li*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

2 Citations (Scopus)

Abstract

Pancreatic cancer (PC) is a highly aggressive malignancy with rising mortality rates globally. Its diagnosis is often challenging due to its asymptomatic nature in the early stages. Consequently, most patients receive a poor prognosis, with low survival rates within 5 years, as the disease is typically detected at an advanced stage, complicating effective treatment. Flavonoids, especially those derived from traditional Chinese herbal medicines, have attracted considerable attention for their potent anti-PC properties. This review highlights the therapeutic potential of these bioactive compounds, which modulate key biological pathways, making them promising candidates for PC intervention. Their mechanisms of action include the regulation of autophagy, apoptosis, cell growth, epithelial-mesenchymal transition, and oxidative stress, as well as enhancing chemotherapeutic sensitivity, exerting antiangiogenic effects, and potentially boosting immunomodulatory responses. The demonstrated benefits of these natural compounds in cancer management have spurred extensive academic interest. Beyond their role as anti-cancer agents, flavonoids may provide both preventive and therapeutic advantages for PC, resonating with the core principles of traditional Chinese medicine for disease prevention and holistic treatment.
Original languageEnglish
Article number1477140
Number of pages19
JournalFrontiers in Nutrition
Volume11
DOIs
Publication statusPublished - 22 Nov 2024

Scopus Subject Areas

  • Food Science
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

User-Defined Keywords

  • flavonoids
  • traditional Chinese herbal medicine
  • treatment modalities
  • pancreatic cancer
  • anti-cancer efficacy

Fingerprint

Dive into the research topics of 'Therapeutic potential of flavonoids from traditional Chinese medicine in pancreatic cancer treatment'. Together they form a unique fingerprint.

Cite this