TY - JOUR
T1 - Therapeutic potential of flavonoids from traditional Chinese medicine in pancreatic cancer treatment
AU - Wan, Qi
AU - Ren, Qing
AU - Qiao, Shuangying
AU - Lyu, Aiping
AU - He, Xingwei
AU - Li, Fangfei
N1 - The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This research was supported by the Hong Kong General Research Fund (Grant Nos.
12101018, 12102518, and 12100719), the Interdisciplinary Research Matching Scheme at Hong Kong Baptist University (RC-IRMS/15–16/01), and the Technology Innovation Strategy Special Fund (Guangdong-Hong Kong-Macau Joint Laboratory, Grant No. 2020B1212030006)
Publisher Copyright:
© 2024 Wan, Ren, Qiao, Lyu, He and Li.
PY - 2024/11/22
Y1 - 2024/11/22
N2 - Pancreatic cancer (PC) is a highly aggressive malignancy with rising mortality rates globally. Its diagnosis is often challenging due to its asymptomatic nature in the early stages. Consequently, most patients receive a poor prognosis, with low survival rates within 5 years, as the disease is typically detected at an advanced stage, complicating effective treatment. Flavonoids, especially those derived from traditional Chinese herbal medicines, have attracted considerable attention for their potent anti-PC properties. This review highlights the therapeutic potential of these bioactive compounds, which modulate key biological pathways, making them promising candidates for PC intervention. Their mechanisms of action include the regulation of autophagy, apoptosis, cell growth, epithelial-mesenchymal transition, and oxidative stress, as well as enhancing chemotherapeutic sensitivity, exerting antiangiogenic effects, and potentially boosting immunomodulatory responses. The demonstrated benefits of these natural compounds in cancer management have spurred extensive academic interest. Beyond their role as anti-cancer agents, flavonoids may provide both preventive and therapeutic advantages for PC, resonating with the core principles of traditional Chinese medicine for disease prevention and holistic treatment.
AB - Pancreatic cancer (PC) is a highly aggressive malignancy with rising mortality rates globally. Its diagnosis is often challenging due to its asymptomatic nature in the early stages. Consequently, most patients receive a poor prognosis, with low survival rates within 5 years, as the disease is typically detected at an advanced stage, complicating effective treatment. Flavonoids, especially those derived from traditional Chinese herbal medicines, have attracted considerable attention for their potent anti-PC properties. This review highlights the therapeutic potential of these bioactive compounds, which modulate key biological pathways, making them promising candidates for PC intervention. Their mechanisms of action include the regulation of autophagy, apoptosis, cell growth, epithelial-mesenchymal transition, and oxidative stress, as well as enhancing chemotherapeutic sensitivity, exerting antiangiogenic effects, and potentially boosting immunomodulatory responses. The demonstrated benefits of these natural compounds in cancer management have spurred extensive academic interest. Beyond their role as anti-cancer agents, flavonoids may provide both preventive and therapeutic advantages for PC, resonating with the core principles of traditional Chinese medicine for disease prevention and holistic treatment.
KW - flavonoids
KW - traditional Chinese herbal medicine
KW - treatment modalities
KW - pancreatic cancer
KW - anti-cancer efficacy
UR - http://www.scopus.com/inward/record.url?scp=85211596875&partnerID=8YFLogxK
U2 - 10.3389/fnut.2024.1477140
DO - 10.3389/fnut.2024.1477140
M3 - Journal article
AN - SCOPUS:85211596875
SN - 2296-861X
VL - 11
JO - Frontiers in Nutrition
JF - Frontiers in Nutrition
M1 - 1477140
ER -