TY - JOUR
T1 - Therapeutic potential and outlook of alternative medicine for osteoporosis
AU - Wang, Tao
AU - Liu, Qian
AU - Tjhioe, William
AU - Zhao, Jinmin
AU - LYU, Aiping
AU - ZHANG, Ge
AU - Tan, Ren Xiang
AU - Zhou, Mengyu
AU - Xu, Jiake
AU - Feng, Hao Tian
N1 - Funding Information:
This study was supported in part by a grant from the National Natural Science Foundation of China (NSFC) (No: 81228013), Guangxi Natural Science Foundation Program (2015GXNSFDA139019), Western Australia Medical & Health Research Infrastructure Fund, Arthritis Australia, The University of Western Australia (UWA) Research Collaboration Awards (2014). Dr. Haotian Feng has been an adjunct research fellowship in the School of Pathology and Laboratory Medicine in the University of Western Australia since 2014 and an adjunct professorship in Guangxi Medical University since 2012. Dr. Qian Liu and Dr. Jiake Xu made mutual collaborative visits in 2014.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Osteoporosis, a bone disease resulting in the loss of bone density and microstructure quality, is often associated with fragility fractures, and the latter imposes a great burden on the patient and society. Although there are several different treatments available for osteoporosis such as hormone replacement therapy, bisphosphonates, Denosumab, and parathyroid hormone, some concerns have been raised regarding the inherent side effects of their long term use. It would be of great relevance to search for alternative natural compounds, which could complementarily overcome the limitations of the currently available therapy. Herein, we review current literature on natural compounds that might have therapeutic values for osteoporosis. Search terms included bone resorption, bone density, osteoporosis, postmenopausal, osteoporosis or bone density conservation agents, and any of the terms related to traditional, herbal, natural therapy, natural health, diet, or phytoestrogens. All the compounds and herbs included in the review are naturally bioactive or are used in folk herbal medicine and have been reported to be capable of attenuating osteopenia or osteoporosis in vivo or in vitro, through various mechanisms – estrogen-like activity, antioxidant and anti-inflammatory properties, or by modulating the key signaling pathways in the pathogenesis of osteoporosis. Through our assessment of the therapeutic potential and outlook of alternative medicine, we aim to provide an appealing perspective for the consideration of the application of a complementary anti-osteoporotic treatment option and prevention strategy for osteoporosis or osteolytic bone disorders.
AB - Osteoporosis, a bone disease resulting in the loss of bone density and microstructure quality, is often associated with fragility fractures, and the latter imposes a great burden on the patient and society. Although there are several different treatments available for osteoporosis such as hormone replacement therapy, bisphosphonates, Denosumab, and parathyroid hormone, some concerns have been raised regarding the inherent side effects of their long term use. It would be of great relevance to search for alternative natural compounds, which could complementarily overcome the limitations of the currently available therapy. Herein, we review current literature on natural compounds that might have therapeutic values for osteoporosis. Search terms included bone resorption, bone density, osteoporosis, postmenopausal, osteoporosis or bone density conservation agents, and any of the terms related to traditional, herbal, natural therapy, natural health, diet, or phytoestrogens. All the compounds and herbs included in the review are naturally bioactive or are used in folk herbal medicine and have been reported to be capable of attenuating osteopenia or osteoporosis in vivo or in vitro, through various mechanisms – estrogen-like activity, antioxidant and anti-inflammatory properties, or by modulating the key signaling pathways in the pathogenesis of osteoporosis. Through our assessment of the therapeutic potential and outlook of alternative medicine, we aim to provide an appealing perspective for the consideration of the application of a complementary anti-osteoporotic treatment option and prevention strategy for osteoporosis or osteolytic bone disorders.
KW - Herbal medicine
KW - Natural compounds
KW - Osteoblast
KW - Osteoclast
KW - Osteoporosis
KW - Postmenopausal osteoporosis
UR - http://www.scopus.com/inward/record.url?scp=85022177286&partnerID=8YFLogxK
U2 - 10.2174/1389450118666170321105425
DO - 10.2174/1389450118666170321105425
M3 - Review article
C2 - 28325144
AN - SCOPUS:85022177286
SN - 1389-4501
VL - 18
SP - 1051
EP - 1068
JO - Current Drug Targets
JF - Current Drug Targets
IS - 9
ER -