TY - JOUR
T1 - Therapeutic peptides in the treatment of digestive inflammation
T2 - Current advances and future prospects
AU - He, Liangliang
AU - Li, Aijing
AU - Yu, Ping
AU - Qin, Shumin
AU - Tan, Hor Yue
AU - Zou, Denglang
AU - Wu, Haomeng
AU - Wang, Shuai
N1 - Funding Information:
This work was supported by National Natural Science Foundation of China Natural (82373940, 32260129, 82304892), Chinese Medicine Guangdong Laboratory Foundation (HQL2024PZ031), State Key Laboratory of Dampness Syndrome of Chinese Medicine China (SZ2021ZZ25), Science and Technology Planning Project of Guangdong Province (2023B1212060063), Guangdong Basic and Applied Basic Research Foundation Planning (2024A1515011699)，Guangzhou Basic and Applied Basic Research Foundation (2024A04J3398, 2024A04J4252), Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine (ZYYCXTU-D-202203), and "the Fundamental Research Funds for the Central Universities". BioRender software (https://app.biorender.com) was used to create figures under an academic license.
Publisher Copyright:
© 2024 The Authors. Published by Elsevier Ltd.
PY - 2024/11
Y1 - 2024/11
N2 - Digestive inflammation is a widespread global issue that significantly impacts quality of life. Recent advances have highlighted the unique potential of therapeutic peptides for treating this condition, owing to their specific bioactivity and high specificity. By specifically targeting key proteins involved in the pathological process and modulating biomolecular functions, therapeutic peptides offer a novel and promising approach to managing digestive inflammation. This review explores the development history, pharmacological characteristics, clinical applications, and regulatory mechanisms of therapeutic peptides in treating digestive inflammation. Additionally, the review addresses pharmacokinetics and quality control methods of therapeutic peptides, focusing on challenges such as low bioavailability, poor stability, and difficulties in delivery. The role of modern biotechnologies and nanotechnologies in overcoming these challenges is also examined. Finally, future directions for therapeutic peptides and their potential impact on clinical applications are discussed, with emphasis placed on their significant role in advancing medical and therapeutic practices.
AB - Digestive inflammation is a widespread global issue that significantly impacts quality of life. Recent advances have highlighted the unique potential of therapeutic peptides for treating this condition, owing to their specific bioactivity and high specificity. By specifically targeting key proteins involved in the pathological process and modulating biomolecular functions, therapeutic peptides offer a novel and promising approach to managing digestive inflammation. This review explores the development history, pharmacological characteristics, clinical applications, and regulatory mechanisms of therapeutic peptides in treating digestive inflammation. Additionally, the review addresses pharmacokinetics and quality control methods of therapeutic peptides, focusing on challenges such as low bioavailability, poor stability, and difficulties in delivery. The role of modern biotechnologies and nanotechnologies in overcoming these challenges is also examined. Finally, future directions for therapeutic peptides and their potential impact on clinical applications are discussed, with emphasis placed on their significant role in advancing medical and therapeutic practices.
KW - Clinical applications
KW - Digestive inflammation
KW - Molecular targets
KW - Pharmacokinetics
KW - Quality control
KW - Regulatory mechanism
KW - Therapeutic peptides
UR - http://www.scopus.com/inward/record.url?scp=85206884651&partnerID=8YFLogxK
U2 - 10.1016/j.phrs.2024.107461
DO - 10.1016/j.phrs.2024.107461
M3 - Review article
C2 - 39423954
AN - SCOPUS:85206884651
SN - 1043-6618
VL - 209
JO - Pharmacological Research
JF - Pharmacological Research
M1 - 107461
ER -
