Therapeutic effect of Chinese medicine formula DSQRL on experimental pulmonary fibrosis

Hong Qi ZHANG; Yu Fung Yau; Kit Ying Szeto; Wai Tak Chan; Jack Wong; Min LI

doi:10.1016/j.jep.2006.08.016

Therapeutic effect of Chinese medicine formula DSQRL on experimental pulmonary fibrosis

Hong Qi ZHANG^*, Yu Fung Yau, Kit Ying Szeto, Wai Tak Chan, Jack Wong, Min LI

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

9 Citations (Scopus)

Abstract

Pulmonary fibrosis (PF) is a restrictive lung disease that may occur idiopathically or as a complication of many diseases. The outcome of the current treatment by glucocorticoids remains very unsatisfactory. This study has tested a new Chinese medicine formula DSQRL for the treatment of experimental PF in comparison with prednisone. Seventy-two rats with PF induced by CCl₄ were randomly divided into four groups to undertake the treatment of either (a) high dose of prednisone; (b) Chinese medicine formula DSQRL; (c) combined treatment of the above two; or (d) tap water of the same volume. At the end of 30 days treatment, the DSQRL treatment achieved a better outcome (p < 0.05) than prednisone in terms of histological examination, bronchoalveolar lavage fluid analysis, hydroxyproline assay and complications. The observations support further investigation and clinical trials of this Chinese medicinal formula for the treatment of PF.

Original language	English
Pages (from-to)	543-546
Number of pages	4
Journal	Journal of Ethnopharmacology
Volume	109
Issue number	3
DOIs	https://doi.org/10.1016/j.jep.2006.08.016
Publication status	Published - 12 Feb 2007

Scopus Subject Areas

Pharmacology
Drug Discovery

User-Defined Keywords

Chinese medicine
Prednisone
Pulmonary fibrosis
Rat

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10.1016/j.jep.2006.08.016

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title = "Therapeutic effect of Chinese medicine formula DSQRL on experimental pulmonary fibrosis",

abstract = "Pulmonary fibrosis (PF) is a restrictive lung disease that may occur idiopathically or as a complication of many diseases. The outcome of the current treatment by glucocorticoids remains very unsatisfactory. This study has tested a new Chinese medicine formula DSQRL for the treatment of experimental PF in comparison with prednisone. Seventy-two rats with PF induced by CCl4 were randomly divided into four groups to undertake the treatment of either (a) high dose of prednisone; (b) Chinese medicine formula DSQRL; (c) combined treatment of the above two; or (d) tap water of the same volume. At the end of 30 days treatment, the DSQRL treatment achieved a better outcome (p < 0.05) than prednisone in terms of histological examination, bronchoalveolar lavage fluid analysis, hydroxyproline assay and complications. The observations support further investigation and clinical trials of this Chinese medicinal formula for the treatment of PF.",

keywords = "Chinese medicine, Prednisone, Pulmonary fibrosis, Rat",

author = "ZHANG, {Hong Qi} and Yau, {Yu Fung} and Szeto, {Kit Ying} and Chan, {Wai Tak} and Jack Wong and Min LI",

note = "Funding Information: We wish to thank Dr. Z.J. Yang and Nickie Chan for their valuable technical supports. The research was supported by HKBU FRG04-05/II-25.",

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doi = "10.1016/j.jep.2006.08.016",

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T1 - Therapeutic effect of Chinese medicine formula DSQRL on experimental pulmonary fibrosis

AU - ZHANG, Hong Qi

AU - Yau, Yu Fung

AU - Szeto, Kit Ying

AU - Chan, Wai Tak

AU - Wong, Jack

AU - LI, Min

N1 - Funding Information: We wish to thank Dr. Z.J. Yang and Nickie Chan for their valuable technical supports. The research was supported by HKBU FRG04-05/II-25.

PY - 2007/2/12

Y1 - 2007/2/12

N2 - Pulmonary fibrosis (PF) is a restrictive lung disease that may occur idiopathically or as a complication of many diseases. The outcome of the current treatment by glucocorticoids remains very unsatisfactory. This study has tested a new Chinese medicine formula DSQRL for the treatment of experimental PF in comparison with prednisone. Seventy-two rats with PF induced by CCl4 were randomly divided into four groups to undertake the treatment of either (a) high dose of prednisone; (b) Chinese medicine formula DSQRL; (c) combined treatment of the above two; or (d) tap water of the same volume. At the end of 30 days treatment, the DSQRL treatment achieved a better outcome (p < 0.05) than prednisone in terms of histological examination, bronchoalveolar lavage fluid analysis, hydroxyproline assay and complications. The observations support further investigation and clinical trials of this Chinese medicinal formula for the treatment of PF.

AB - Pulmonary fibrosis (PF) is a restrictive lung disease that may occur idiopathically or as a complication of many diseases. The outcome of the current treatment by glucocorticoids remains very unsatisfactory. This study has tested a new Chinese medicine formula DSQRL for the treatment of experimental PF in comparison with prednisone. Seventy-two rats with PF induced by CCl4 were randomly divided into four groups to undertake the treatment of either (a) high dose of prednisone; (b) Chinese medicine formula DSQRL; (c) combined treatment of the above two; or (d) tap water of the same volume. At the end of 30 days treatment, the DSQRL treatment achieved a better outcome (p < 0.05) than prednisone in terms of histological examination, bronchoalveolar lavage fluid analysis, hydroxyproline assay and complications. The observations support further investigation and clinical trials of this Chinese medicinal formula for the treatment of PF.

KW - Chinese medicine

KW - Prednisone

KW - Pulmonary fibrosis

KW - Rat

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Therapeutic effect of Chinese medicine formula DSQRL on experimental pulmonary fibrosis

Abstract

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