TY - JOUR
T1 - Theabrownin and Poria cocos Polysaccharide Improve Lipid Metabolism via Modulation of Bile Acid and Fatty Acid Metabolism
AU - Wang, Jieyi
AU - Zheng, Dan
AU - Huang, Fengjie
AU - Zhao, Aihua
AU - Kuang, Junliang
AU - Ren, Zhenxing
AU - Chen, Tianlu
AU - Lei, Jing
AU - Lin, Jingchao
AU - Wang, Xiaoning
AU - Jia, Wei
AU - Xie, Guoxiang
AU - Zheng, Xiaojiao
N1 - Funding Information:
This work was supported by Natural Science Foundation of Shanghai (21ZR448800), National Natural Science Foundation of China (82122012, 82170833) and Shanghai Sixth People’s Hospital Project (ynqn202120).
Publisher Copyright:
© 2022 Wang, Zheng, Huang, Zhao, Kuang, Ren, Chen, Lei, Lin, Wang, Jia, Xie and Zheng.
PY - 2022/6/27
Y1 - 2022/6/27
N2 - Nonalcoholic fatty liver disease (NAFLD) is prevalent worldwide, while no pharmaceutical treatment has been approved. Natural herbs are promising for their amelioration effect on lipid metabolism. Theabrownin (TB) and Poria cocos polysaccharide (PCP) have been reported to have effect on hyperlipidemia and diabetes. Here, we compared the effect of individual TB or PCP and the combination of TB and PCP (TB + PCP) on NAFLD phenotypes and the alteration of metabolism in the mice with high-fat diet. The results showed that TB, PCP, and TB + PCP reduced serum and hepatic lipid levels, among which TB + PCP was the most effective. Serum metabolomic profile and liver mRNA analyses revealed that the treatments altered metabolic pathways involved in fatty acid metabolism, bile acid metabolism, and tricarboxylic acid cycle, which was also most significant in the TB + PCP group. This study demonstrated that TB, PCP, especially the combination of TB and PCP could be potential therapeutic formula for NAFLD that promoted lipid utilization and inhibited lipid synthesis and absorption.
AB - Nonalcoholic fatty liver disease (NAFLD) is prevalent worldwide, while no pharmaceutical treatment has been approved. Natural herbs are promising for their amelioration effect on lipid metabolism. Theabrownin (TB) and Poria cocos polysaccharide (PCP) have been reported to have effect on hyperlipidemia and diabetes. Here, we compared the effect of individual TB or PCP and the combination of TB and PCP (TB + PCP) on NAFLD phenotypes and the alteration of metabolism in the mice with high-fat diet. The results showed that TB, PCP, and TB + PCP reduced serum and hepatic lipid levels, among which TB + PCP was the most effective. Serum metabolomic profile and liver mRNA analyses revealed that the treatments altered metabolic pathways involved in fatty acid metabolism, bile acid metabolism, and tricarboxylic acid cycle, which was also most significant in the TB + PCP group. This study demonstrated that TB, PCP, especially the combination of TB and PCP could be potential therapeutic formula for NAFLD that promoted lipid utilization and inhibited lipid synthesis and absorption.
KW - lipid metabolism
KW - metabolomics
KW - nonalcoholic fatty liver disease
KW - Poria cocos polysaccharide
KW - theabrownin
UR - http://www.scopus.com/inward/record.url?scp=85133908636&partnerID=8YFLogxK
U2 - 10.3389/fphar.2022.875549
DO - 10.3389/fphar.2022.875549
M3 - Journal article
AN - SCOPUS:85133908636
SN - 1663-9812
VL - 13
JO - Frontiers in Pharmacology
JF - Frontiers in Pharmacology
M1 - 875549
ER -
