@inproceedings{3cda073d458540ecb1ec598a1191f4dd,
title = "The use of a noninvasive and nondestructive method, microcomputed tomography, to evaluate the anti-osteoporotic activity of erxian decoction, a Chinese medicinal formula, in a rat model of menopausal osteoporosis",
abstract = "Aim of the study: The anti-osteoporotic activity of Erxian Decoction, a Chinese medicinal formula, in a rat model of menopausal osteoporosis was evaluated by microcomputed tomography (microCT). Materials and methods: Menopause causes a decline in both endocrine function and bone mineral density in human. In this study, 20-month-old female Sprague-Dawley-rats (SD-rats) with a low serum estradiol level and bone mineral density were employed. The anti-osteoporotic activity of EXD was assessed by the determination of trabecular material bone mineral density at the L2 mid-vertebral body after treatment. Serum estrogen levels were also determined to assess the effect of EXD on the endocrine status. Results: Results revealed a significant elevation in serum estradiol level and trabecular bone mineral density at the L2 mid-vertebral body in the EXD-treated menopausal rat model. Conclusions: The results obtained from the present investigation revealed that the EXD had anti-osteoporotic activity as evidenced by an increase of serum estradiol level and bone mineral density.",
keywords = "Microcomputed Tomography, osteoporosis, Erxian Decoction, Chinese medicine, estradiol and menopause",
author = "Sze, {Stephen Cho Wing} and Y. Tong and Y.B. Zhang and L.L.D. Zhong and A.S.L. Lau and C.M.N. Yow and Y.M. Lai and T.B. Ng",
year = "2009",
month = oct,
doi = "10.1109/BMEI.2009.5304821",
language = "English",
isbn = "9781424441327",
series = "International Conference on Biomedical Engineering and Informatics",
publisher = "IEEE",
booktitle = "2009 2nd International Conference on Biomedical Engineering and Informatics",
address = "United States",
note = "2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009 ; Conference date: 17-10-2009 Through 19-10-2009",
}