TY - GEN
T1 - The use of a noninvasive and nondestructive method, microcomputed tomography, to evaluate the anti-osteoporotic activity of erxian decoction, a Chinese medicinal formula, in a rat model of menopausal osteoporosis
AU - Sze, Stephen Cho Wing
AU - Tong, Y.
AU - Zhang, Y.B.
AU - Zhong, L.L.D.
AU - Lau, A.S.L.
AU - Yow, C.M.N.
AU - Lai, Y.M.
AU - Ng, T.B.
PY - 2009/10
Y1 - 2009/10
N2 - Aim of the study: The anti-osteoporotic activity of Erxian Decoction, a Chinese medicinal formula, in a rat model of menopausal osteoporosis was evaluated by microcomputed tomography (microCT). Materials and methods: Menopause causes a decline in both endocrine function and bone mineral density in human. In this study, 20-month-old female Sprague-Dawley-rats (SD-rats) with a low serum estradiol level and bone mineral density were employed. The anti-osteoporotic activity of EXD was assessed by the determination of trabecular material bone mineral density at the L2 mid-vertebral body after treatment. Serum estrogen levels were also determined to assess the effect of EXD on the endocrine status. Results: Results revealed a significant elevation in serum estradiol level and trabecular bone mineral density at the L2 mid-vertebral body in the EXD-treated menopausal rat model. Conclusions: The results obtained from the present investigation revealed that the EXD had anti-osteoporotic activity as evidenced by an increase of serum estradiol level and bone mineral density.
AB - Aim of the study: The anti-osteoporotic activity of Erxian Decoction, a Chinese medicinal formula, in a rat model of menopausal osteoporosis was evaluated by microcomputed tomography (microCT). Materials and methods: Menopause causes a decline in both endocrine function and bone mineral density in human. In this study, 20-month-old female Sprague-Dawley-rats (SD-rats) with a low serum estradiol level and bone mineral density were employed. The anti-osteoporotic activity of EXD was assessed by the determination of trabecular material bone mineral density at the L2 mid-vertebral body after treatment. Serum estrogen levels were also determined to assess the effect of EXD on the endocrine status. Results: Results revealed a significant elevation in serum estradiol level and trabecular bone mineral density at the L2 mid-vertebral body in the EXD-treated menopausal rat model. Conclusions: The results obtained from the present investigation revealed that the EXD had anti-osteoporotic activity as evidenced by an increase of serum estradiol level and bone mineral density.
KW - Microcomputed Tomography
KW - osteoporosis
KW - Erxian Decoction
KW - Chinese medicine
KW - estradiol and menopause
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-74049126578&partnerID=MN8TOARS
U2 - 10.1109/BMEI.2009.5304821
DO - 10.1109/BMEI.2009.5304821
M3 - Conference contribution
SN - 9781424441327
T3 - International Conference on Biomedical Engineering and Informatics
BT - 2009 2nd International Conference on Biomedical Engineering and Informatics
PB - IEEE
T2 - 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009
Y2 - 17 October 2009 through 19 October 2009
ER -