The therapeutic potential of targeting barf1 in EBV-associated malignancies

Angela Kwok Fung Lo; Christopher W. Dawson; Hong Lok Lung; Ka-Leung Wong; Lawrence S. Young

doi:10.3390/cancers12071940

The therapeutic potential of targeting barf1 in EBV-associated malignancies

Angela Kwok Fung Lo, Christopher W. Dawson, Hong Lok Lung, Ka-Leung Wong^*, Lawrence S. Young^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

16 Citations (Scopus)

Abstract

Epstein-Barr virus (EBV) is closely linked to the development of a number of human cancers. EBV-associated malignancies are characterized by a restricted pattern of viral latent protein expression which is sufficient for the virus to both initiate and sustain cell growth and to protect virus-infected cells from immune attack. Expression of these EBV proteins in malignant cells provides an attractive target for therapeutic intervention. Among the viral proteins expressed in the EBV-associated epithelial malignancies, the protein encoded by the BamHI-A rightward frame 1 (BARF1) is of particular interest. BARF1 is a viral oncoprotein selectively expressed in latently infected epithelial cancers, nasopharyngeal carcinoma (NPC) and EBV-positive gastric cancer (EBV-GC). Here, we review the roles of BARF1 in oncogenesis and immunomodulation. We also discuss potential strategies for targeting the BARF1 protein as a novel therapy for EBV-driven epithelial cancers.

Original language	English
Article number	1940
Pages (from-to)	1-12
Number of pages	12
Journal	Cancers
Volume	12
Issue number	7
DOIs	https://doi.org/10.3390/cancers12071940
Publication status	Published - 17 Jul 2020

Scopus Subject Areas

Oncology
Cancer Research

User-Defined Keywords

BARF1
EBV
EBV-associated cancers
Immunotherapy
Peptide therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cancers12071940

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title = "The therapeutic potential of targeting barf1 in EBV-associated malignancies",

abstract = "Epstein-Barr virus (EBV) is closely linked to the development of a number of human cancers. EBV-associated malignancies are characterized by a restricted pattern of viral latent protein expression which is sufficient for the virus to both initiate and sustain cell growth and to protect virus-infected cells from immune attack. Expression of these EBV proteins in malignant cells provides an attractive target for therapeutic intervention. Among the viral proteins expressed in the EBV-associated epithelial malignancies, the protein encoded by the BamHI-A rightward frame 1 (BARF1) is of particular interest. BARF1 is a viral oncoprotein selectively expressed in latently infected epithelial cancers, nasopharyngeal carcinoma (NPC) and EBV-positive gastric cancer (EBV-GC). Here, we review the roles of BARF1 in oncogenesis and immunomodulation. We also discuss potential strategies for targeting the BARF1 protein as a novel therapy for EBV-driven epithelial cancers.",

keywords = "BARF1, EBV, EBV-associated cancers, Immunotherapy, Peptide therapy",

author = "Lo, {Angela Kwok Fung} and Dawson, {Christopher W.} and Lung, {Hong Lok} and Ka-Leung Wong and Young, {Lawrence S.}",

note = "Funding: This research received no external funding.",

year = "2020",

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doi = "10.3390/cancers12071940",

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T1 - The therapeutic potential of targeting barf1 in EBV-associated malignancies

AU - Lo, Angela Kwok Fung

AU - Dawson, Christopher W.

AU - Lung, Hong Lok

AU - Wong, Ka-Leung

AU - Young, Lawrence S.

N1 - Funding: This research received no external funding.

PY - 2020/7/17

Y1 - 2020/7/17

N2 - Epstein-Barr virus (EBV) is closely linked to the development of a number of human cancers. EBV-associated malignancies are characterized by a restricted pattern of viral latent protein expression which is sufficient for the virus to both initiate and sustain cell growth and to protect virus-infected cells from immune attack. Expression of these EBV proteins in malignant cells provides an attractive target for therapeutic intervention. Among the viral proteins expressed in the EBV-associated epithelial malignancies, the protein encoded by the BamHI-A rightward frame 1 (BARF1) is of particular interest. BARF1 is a viral oncoprotein selectively expressed in latently infected epithelial cancers, nasopharyngeal carcinoma (NPC) and EBV-positive gastric cancer (EBV-GC). Here, we review the roles of BARF1 in oncogenesis and immunomodulation. We also discuss potential strategies for targeting the BARF1 protein as a novel therapy for EBV-driven epithelial cancers.

AB - Epstein-Barr virus (EBV) is closely linked to the development of a number of human cancers. EBV-associated malignancies are characterized by a restricted pattern of viral latent protein expression which is sufficient for the virus to both initiate and sustain cell growth and to protect virus-infected cells from immune attack. Expression of these EBV proteins in malignant cells provides an attractive target for therapeutic intervention. Among the viral proteins expressed in the EBV-associated epithelial malignancies, the protein encoded by the BamHI-A rightward frame 1 (BARF1) is of particular interest. BARF1 is a viral oncoprotein selectively expressed in latently infected epithelial cancers, nasopharyngeal carcinoma (NPC) and EBV-positive gastric cancer (EBV-GC). Here, we review the roles of BARF1 in oncogenesis and immunomodulation. We also discuss potential strategies for targeting the BARF1 protein as a novel therapy for EBV-driven epithelial cancers.

KW - BARF1

KW - EBV

KW - EBV-associated cancers

KW - Immunotherapy

KW - Peptide therapy

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U2 - 10.3390/cancers12071940

DO - 10.3390/cancers12071940

M3 - Review article

AN - SCOPUS:85088496386

SN - 2072-6694

VL - 12

SP - 1

EP - 12

JO - Cancers

JF - Cancers

IS - 7

M1 - 1940

ER -

The therapeutic potential of targeting barf1 in EBV-associated malignancies

Abstract

Scopus Subject Areas

User-Defined Keywords

UN SDGs

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