The Rules and Functions of Nucleocytoplasmic Shuttling Proteins

Xuekun Fu, Chao Liang, Fangfei Li, Luyao Wang, Xiaoqiu Wu, Aiping Lu, Guozhi Xiao*, Ge Zhang*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

46 Citations (Scopus)


Biological macromolecules are the basis of life activities. There is a separation of spatial dimension between DNA replication and RNA biogenesis, and protein synthesis, which is an interesting phenomenon. The former occurs in the cell nucleus, while the latter in the cytoplasm. The separation requires protein to transport across the nuclear envelope to realize a variety of biological functions. Nucleocytoplasmic transport of protein including import to the nucleus and export to the cytoplasm is a complicated process that requires involvement and interaction of many proteins. In recent years, many studies have found that proteins constantly shuttle between the cytoplasm and the nucleus. These shuttling proteins play a crucial role as transport carriers and signal transduction regulators within cells. In this review, we describe the mechanism of nucleocytoplasmic transport of shuttling proteins and summarize some important diseases related shuttling proteins.

Original languageEnglish
Article number1445
JournalInternational Journal of Molecular Sciences
Issue number5
Publication statusPublished - 12 May 2018

Scopus Subject Areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

User-Defined Keywords

  • Cancer
  • Fanconi anemia
  • Leukemia
  • Neurodegenerative diseases
  • Nucleocytoplasmic transport
  • Osteoporosis
  • Shuttling protein


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