TY - JOUR
T1 - The Roles of Sclerostin in Immune System and the Applications of Aptamers in Immune-Related Research
AU - Sun, Meiheng
AU - Chen, Zihao
AU - Wu, Xiaoqiu
AU - Yu, Yuanyuan
AU - Wang, Luyao
AU - Lu, Aiping
AU - Zhang, Ge
AU - Li, Fangfei
N1 - Funding Information:
This study was supported by the National Key Research and Development Program of China (2018YFA0800804), the Interdisciplinary Research Matching Scheme Hong Kong Baptist University (RC-IRMS/15-16/01), the Hong Kong General Research Fund (12101018, 12102518, 12102120), Theme-based Research Scheme Hong Kong Research Grants Council (TRS/RGC T12-201-20-R), and the National Natural Science Foundation Council of China (81703049).
Copyright © 2021 Sun, Chen, Wu, Yu, Wang, Lu, Zhang and Li.
PY - 2021/2/25
Y1 - 2021/2/25
N2 - Wnt signaling is one of the fundamental pathways that play a major role in almost every aspect of biological systems. In addition to the well-known influence of Wnt signaling on bone formation, its essential role in the immune system also attracted increasing attention. Sclerostin, a confirmed Wnt antagonist, is also proven to modulate the development and differentiation of normal immune cells, particularly B cells. Aptamers, single-stranded (ss) oligonucleotides, are capable of specifically binding to a variety of target molecules by virtue of their unique three-dimensional structures. With in-depth study of those functional nucleic acids, they have been gradually applied to diagnostic and therapeutic area in immune diseases due to their various advantages over antibodies. In this review, we focus on several issues including the roles of Wnt signaling and Wnt antagonist sclerostin in the immune system. For the sake of understanding, current examples of aptamers applications for the immune diseases are also discussed. At the end of this review, we propose our ideas for the future research directions.
AB - Wnt signaling is one of the fundamental pathways that play a major role in almost every aspect of biological systems. In addition to the well-known influence of Wnt signaling on bone formation, its essential role in the immune system also attracted increasing attention. Sclerostin, a confirmed Wnt antagonist, is also proven to modulate the development and differentiation of normal immune cells, particularly B cells. Aptamers, single-stranded (ss) oligonucleotides, are capable of specifically binding to a variety of target molecules by virtue of their unique three-dimensional structures. With in-depth study of those functional nucleic acids, they have been gradually applied to diagnostic and therapeutic area in immune diseases due to their various advantages over antibodies. In this review, we focus on several issues including the roles of Wnt signaling and Wnt antagonist sclerostin in the immune system. For the sake of understanding, current examples of aptamers applications for the immune diseases are also discussed. At the end of this review, we propose our ideas for the future research directions.
KW - aptamers
KW - B cell malignancies
KW - immune system
KW - sclerostin
KW - Wnt signaling pathway
UR - http://www.scopus.com/inward/record.url?scp=85102462869&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2021.602330
DO - 10.3389/fimmu.2021.602330
M3 - Journal article
C2 - 33717084
AN - SCOPUS:85102462869
SN - 1664-3224
VL - 12
JO - Frontiers in Immunology
JF - Frontiers in Immunology
M1 - 602330
ER -
