TY - JOUR
T1 - The roles of hepatokine and osteokine in liver-bone crosstalk
T2 - Advance in basic and clinical aspects
AU - LI, Zhanghao
AU - Wen, Xiaoxin
AU - LI, Nanxi
AU - ZHONG, Chuanxin
AU - Chen, Li
AU - Zhang, Feng
AU - ZHANG, Ge
AU - Lu, Aiping
AU - LIU, Jin
N1 - Funding Information:
This work was financially supported by the Theme-based Research Scheme (T12-201/20-R) and General Research Fund (12136616 and 12103519) of Research Grants Council of Hong Kong SAR, The 2020 Guangdong Provincial Science and Technology Innovation Strategy Special Fund (Guangdong-Hong Kong-Macau Joint Lab, No: 2020B1212030006), Interdisciplinary Research Clusters Matching Scheme of Hong Kong Baptist University (RC-IRCs/17-18/02). Acknowledgments
Publisher Copyright:
Copyright © 2023 Li, Wen, Li, Zhong, Chen, Zhang, Zhang, Lyu and Liu.
PY - 2023/4/6
Y1 - 2023/4/6
N2 - Both the liver and bone are important secretory organs in the endocrine system. By secreting organ factors (hepatokines), the liver regulates the activity of other organs. Similarly, bone-derived factors, osteokines, are created during bone metabolism and act in an endocrine manner. Generally, the dysregulation of hepatokines is frequently accompanied by changes in bone mass, and osteokines can also disrupt liver metabolism. The crosstalk between the liver and bone, particularly the function and mechanism of hepatokines and osteokines, has increasingly gained notoriety as a topic of interest in recent years. Here, based on preclinical and clinical evidence, we summarize the potential roles of hepatokines and osteokines in liver-bone interaction, discuss the current shortcomings and contradictions, and make recommendations for future research.
AB - Both the liver and bone are important secretory organs in the endocrine system. By secreting organ factors (hepatokines), the liver regulates the activity of other organs. Similarly, bone-derived factors, osteokines, are created during bone metabolism and act in an endocrine manner. Generally, the dysregulation of hepatokines is frequently accompanied by changes in bone mass, and osteokines can also disrupt liver metabolism. The crosstalk between the liver and bone, particularly the function and mechanism of hepatokines and osteokines, has increasingly gained notoriety as a topic of interest in recent years. Here, based on preclinical and clinical evidence, we summarize the potential roles of hepatokines and osteokines in liver-bone interaction, discuss the current shortcomings and contradictions, and make recommendations for future research.
KW - bone
KW - endocrine
KW - hepatokine
KW - liver
KW - osteokine
UR - http://www.scopus.com/inward/record.url?scp=85158083312&partnerID=8YFLogxK
U2 - 10.3389/fendo.2023.1149233
DO - 10.3389/fendo.2023.1149233
M3 - Review article
SN - 1664-2392
VL - 14
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology
M1 - 1149233
ER -