The Role of Exosomal microRNA in Cancer Drug Resistance

Qiao Ru Guo; Hui Wang; Ying Da Yan; Yun Liu; Chao Yue Su; Hubiao Chen; Yan Yan Yan; Rameshwar Adhikari; Qiang Wu; Jian Ye Zhang

doi:10.3389/fonc.2020.00472

The Role of Exosomal microRNA in Cancer Drug Resistance

Qiao Ru Guo, Hui Wang, Ying Da Yan, Yun Liu, Chao Yue Su, Hubiao Chen, Yan Yan Yan, Rameshwar Adhikari, Qiang Wu^*, Jian Ye Zhang^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

42 Citations (Scopus)

Abstract

Exosomes affect the initiation and progression of cancers. In the tumor microenvironment, not only cancer cells, but also fibroblasts and immunocytes secrete exosomes. Exosomes act as a communicator between cells by transferring different cargos and microRNAs (miRNAs). Drug resistance is one of the critical factors affecting therapeutic effect in the course of cancer treatment. The currently known mechanisms of drug resistance include drug efflux, alterations in drug metabolism, DNA damage repair, alterations of energy programming, cancer stem cells and epigenetic changes. Many studies have shown that miRNA carried by exosomes is closely associated with the development of drug resistance mediated by the above-mentioned mechanisms. This review article will discuss how exosomal miRNAs regulate the drug resistance.

Original language	English
Article number	472
Number of pages	12
Journal	Frontiers in Oncology
Volume	10
DOIs	https://doi.org/10.3389/fonc.2020.00472
Publication status	Published - 7 Apr 2020

Scopus Subject Areas

Oncology
Cancer Research

User-Defined Keywords

cancer
drug resistance
exosome
mechanism
miRNA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fonc.2020.00472

Cite this

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title = "The Role of Exosomal microRNA in Cancer Drug Resistance",

abstract = "Exosomes affect the initiation and progression of cancers. In the tumor microenvironment, not only cancer cells, but also fibroblasts and immunocytes secrete exosomes. Exosomes act as a communicator between cells by transferring different cargos and microRNAs (miRNAs). Drug resistance is one of the critical factors affecting therapeutic effect in the course of cancer treatment. The currently known mechanisms of drug resistance include drug efflux, alterations in drug metabolism, DNA damage repair, alterations of energy programming, cancer stem cells and epigenetic changes. Many studies have shown that miRNA carried by exosomes is closely associated with the development of drug resistance mediated by the above-mentioned mechanisms. This review article will discuss how exosomal miRNAs regulate the drug resistance.",

keywords = "cancer, drug resistance, exosome, mechanism, miRNA",

author = "Guo, {Qiao Ru} and Hui Wang and Yan, {Ying Da} and Yun Liu and Su, {Chao Yue} and Hubiao Chen and Yan, {Yan Yan} and Rameshwar Adhikari and Qiang Wu and Zhang, {Jian Ye}",

note = "Funding Information: This work was supported by National Natural Science Foundation of China (81773888, U1903126 and 81902152), Guangdong Basic and Applied Basic Research Foundation (2020A1515010005, 2020A1515010605), Fund from Guangzhou Institute of Pediatrics/Guangzhou Women and Children's Medical Center (No: IP-2018-012).",

year = "2020",

month = apr,

day = "7",

doi = "10.3389/fonc.2020.00472",

language = "English",

volume = "10",

journal = "Frontiers in Oncology",

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TY - JOUR

T1 - The Role of Exosomal microRNA in Cancer Drug Resistance

AU - Guo, Qiao Ru

AU - Wang, Hui

AU - Yan, Ying Da

AU - Liu, Yun

AU - Su, Chao Yue

AU - Chen, Hubiao

AU - Yan, Yan Yan

AU - Adhikari, Rameshwar

AU - Wu, Qiang

AU - Zhang, Jian Ye

N1 - Funding Information: This work was supported by National Natural Science Foundation of China (81773888, U1903126 and 81902152), Guangdong Basic and Applied Basic Research Foundation (2020A1515010005, 2020A1515010605), Fund from Guangzhou Institute of Pediatrics/Guangzhou Women and Children's Medical Center (No: IP-2018-012).

PY - 2020/4/7

Y1 - 2020/4/7

N2 - Exosomes affect the initiation and progression of cancers. In the tumor microenvironment, not only cancer cells, but also fibroblasts and immunocytes secrete exosomes. Exosomes act as a communicator between cells by transferring different cargos and microRNAs (miRNAs). Drug resistance is one of the critical factors affecting therapeutic effect in the course of cancer treatment. The currently known mechanisms of drug resistance include drug efflux, alterations in drug metabolism, DNA damage repair, alterations of energy programming, cancer stem cells and epigenetic changes. Many studies have shown that miRNA carried by exosomes is closely associated with the development of drug resistance mediated by the above-mentioned mechanisms. This review article will discuss how exosomal miRNAs regulate the drug resistance.

AB - Exosomes affect the initiation and progression of cancers. In the tumor microenvironment, not only cancer cells, but also fibroblasts and immunocytes secrete exosomes. Exosomes act as a communicator between cells by transferring different cargos and microRNAs (miRNAs). Drug resistance is one of the critical factors affecting therapeutic effect in the course of cancer treatment. The currently known mechanisms of drug resistance include drug efflux, alterations in drug metabolism, DNA damage repair, alterations of energy programming, cancer stem cells and epigenetic changes. Many studies have shown that miRNA carried by exosomes is closely associated with the development of drug resistance mediated by the above-mentioned mechanisms. This review article will discuss how exosomal miRNAs regulate the drug resistance.

KW - cancer

KW - drug resistance

KW - exosome

KW - mechanism

KW - miRNA

UR - http://www.scopus.com/inward/record.url?scp=85083489130&partnerID=8YFLogxK

U2 - 10.3389/fonc.2020.00472

DO - 10.3389/fonc.2020.00472

M3 - Review article

AN - SCOPUS:85083489130

SN - 2234-943X

VL - 10

JO - Frontiers in Oncology

JF - Frontiers in Oncology

M1 - 472

ER -

The Role of Exosomal microRNA in Cancer Drug Resistance

Abstract

Scopus Subject Areas

User-Defined Keywords

UN SDGs

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