TY - JOUR
T1 - The Role of EBV-Encoded LMP1 in the NPC Tumor Microenvironment
T2 - From Function to Therapy
AU - Lo, Angela Kwok Fung
AU - Dawson, Christopher W.
AU - Lung, Hong Lok
AU - Wong, Ka-Leung
AU - Young, Lawrence S.
N1 - Funding Information:
This work was supported by Research Grants Council of Hong Kong (Grant No. HKBU12300117).
PY - 2021/2/25
Y1 - 2021/2/25
N2 - Nasopharyngeal carcinoma (NPC) is closely associated with Epstein-Barr virus (EBV) infection. It is also characterized by heavy infiltration with non-malignant leucocytes. The EBV-encoded latent membrane protein 1 (LMP1) is believed to play an important role in NPC pathogenesis by virtue of its ability to activate multiple cell signaling pathways which collectively promote cell proliferation and survival, angiogenesis, invasiveness, and aerobic glycolysis. LMP1 also affects cell-cell interactions, antigen presentation, and cytokine and chemokine production. Here, we discuss how LMP1 modulates local immune responses that contribute to the establishment of the NPC tumor microenvironment. We also discuss strategies for targeting the LMP1 protein as a novel therapy for EBV-driven malignancies.
AB - Nasopharyngeal carcinoma (NPC) is closely associated with Epstein-Barr virus (EBV) infection. It is also characterized by heavy infiltration with non-malignant leucocytes. The EBV-encoded latent membrane protein 1 (LMP1) is believed to play an important role in NPC pathogenesis by virtue of its ability to activate multiple cell signaling pathways which collectively promote cell proliferation and survival, angiogenesis, invasiveness, and aerobic glycolysis. LMP1 also affects cell-cell interactions, antigen presentation, and cytokine and chemokine production. Here, we discuss how LMP1 modulates local immune responses that contribute to the establishment of the NPC tumor microenvironment. We also discuss strategies for targeting the LMP1 protein as a novel therapy for EBV-driven malignancies.
KW - Epstein-Barr virus
KW - latent membrane protein 1
KW - nasopharyngeal carcinoma
KW - therapy
KW - tumor microenvironment
UR - http://www.scopus.com/inward/record.url?scp=85102475402&partnerID=8YFLogxK
U2 - 10.3389/fonc.2021.640207
DO - 10.3389/fonc.2021.640207
M3 - Review article
AN - SCOPUS:85102475402
SN - 2234-943X
VL - 11
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 640207
ER -