The role of coupling connections in a model of the cortico-basal ganglia-thalamocortical neural loop for the generation of beta oscillations

Chen Liu, Changsong ZHOU*, Jiang Wang, Chris Fietkiewicz, Kenneth A. Loparo

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Excessive neural synchronization in the cortico-basal ganglia-thalamocortical circuits in the beta ( [Formula presented]) frequency range (12–35 Hz) is closely associated with dopamine depletion in Parkinson's disease (PD) and correlated with movement impairments, but the neural basis remains unclear. In this work, we establish a double-oscillator neural mass model for the cortico-basal ganglia-thalamocortical closed-loop system and explore the impacts of dopamine depletion induced changes in coupling connections within or between the two oscillators on neural activities within the loop. Spectral analysis of the neural mass activities revealed that the power and frequency of their principal components are greatly dependent on the coupling strengths between nuclei. We found that the increased intra-coupling in the basal ganglia-thalamic (BG-Th) oscillator contributes to increased oscillations in the lower [Formula presented] frequency band (12–25 Hz), while increased intra-coupling in the cortical oscillator mainly contributes to increased oscillations in the upper [Formula presented] frequency band (26–35 Hz). Interestingly, pathological upper [Formula presented] oscillations in the cortical oscillator may be another origin of the lower [Formula presented] oscillations in the BG-Th oscillator, in addition to increased intra-coupling strength within the BG-Th network. Lower [Formula presented] oscillations in the BG-Th oscillator can also change the dominant oscillation frequency of a cortical nucleus from the upper to the lower [Formula presented] band. Thus, this work may pave the way towards revealing a possible neural basis underlying the Parkinsonian state.

Original languageEnglish
Pages (from-to)381-392
Number of pages12
JournalNeural Networks
Volume123
DOIs
Publication statusPublished - Mar 2020

Scopus Subject Areas

  • Cognitive Neuroscience
  • Artificial Intelligence

User-Defined Keywords

  • Beta oscillations
  • Cortico-basal ganglia-thalamocortical circuits
  • Coupling strength
  • Double-oscillator system
  • Neural mass model

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