@article{805b0a3dc9d34055b9cfd0fdb6479fb6,
title = "The role of CKIP-1 in osteoporosis development and treatment",
abstract = "Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass and deterioration of bone microarchitecture, which results in increased bone fragility and fracture risk. Casein kinase 2-interacting protein-1 (CKIP-1) is a protein that plays an important role in regulation of bone formation. The effect of CKIP-1 on bone formation is mainly mediated through negative regulation of the bone morphogenetic protein pathway. In addition, CKIP-1 has an important role in the progression of osteoporosis. This review provides a summary of the recent studies on the role of CKIP-1 in osteoporosis development and treatment.",
keywords = "BMP pathway, Bone formation, CKIP-1, Osteoporosis",
author = "X. Peng and X. Wu and J. Zhang and G. Zhang and G. Li and X. Pan",
note = "Funding Information: The work was partially supported by grants from Research Grants Council of the Hong Kong Special Administrative Region, China (Project No. 14119115, 14160917, 9054014 N\_CityU102/15, T13-402/17-N); National Natural Science Foundation of China (81371946, 81430049 and 81772322); Hong Kong Innovation Technology Commission Funds (ITS/UIM-305) and grants from the Shenzhen Science and Technology Innovation Council of China (JCYJ20150630165236960, JSGG20160229195900623 and JCYJ20150402152005636), Sanming Project of medicine in Shenzhen (SZSM20150602). Publisher copyright: {\textcopyright} 2018 Peng et al.",
year = "2018",
month = feb,
doi = "10.1302/2046-3758.72.BJR-2017-0172.R1",
language = "English",
volume = "7",
pages = "173--178",
journal = "Bone and Joint Research",
issn = "2046-3758",
publisher = "British Editorial Society of Bone and Joint Surgery",
number = "2",
}