The role of CKIP-1 in osteoporosis development and treatment

X. Peng, X. Wu, J. Zhang, G. Zhang, G. Li, X. Pan*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

25 Citations (Scopus)


Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass and deterioration of bone microarchitecture, which results in increased bone fragility and fracture risk. Casein kinase 2-interacting protein-1 (CKIP-1) is a protein that plays an important role in regulation of bone formation. The effect of CKIP-1 on bone formation is mainly mediated through negative regulation of the bone morphogenetic protein pathway. In addition, CKIP-1 has an important role in the progression of osteoporosis. This review provides a summary of the recent studies on the role of CKIP-1 in osteoporosis development and treatment.

Original languageEnglish
Pages (from-to)173-178
Number of pages6
JournalBone and Joint Research
Issue number2
Publication statusPublished - Feb 2018

Scopus Subject Areas

  • Surgery
  • Orthopedics and Sports Medicine

User-Defined Keywords

  • BMP pathway
  • Bone formation
  • CKIP-1
  • Osteoporosis


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