Abstract
Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass and deterioration of bone microarchitecture, which results in increased bone fragility and fracture risk. Casein kinase 2-interacting protein-1 (CKIP-1) is a protein that plays an important role in regulation of bone formation. The effect of CKIP-1 on bone formation is mainly mediated through negative regulation of the bone morphogenetic protein pathway. In addition, CKIP-1 has an important role in the progression of osteoporosis. This review provides a summary of the recent studies on the role of CKIP-1 in osteoporosis development and treatment.
Original language | English |
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Pages (from-to) | 173-178 |
Number of pages | 6 |
Journal | Bone and Joint Research |
Volume | 7 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 2018 |
Scopus Subject Areas
- Surgery
- Orthopedics and Sports Medicine
User-Defined Keywords
- BMP pathway
- Bone formation
- CKIP-1
- Osteoporosis