The role of CKIP-1 in osteoporosis development and treatment

X. Peng; X. Wu; J. Zhang; G. Zhang; G. Li; X. Pan

doi:10.1302/2046-3758.72.BJR-2017-0172.R1

The role of CKIP-1 in osteoporosis development and treatment

X. Peng, X. Wu, J. Zhang, G. Zhang, G. Li, X. Pan^*

^*Corresponding author for this work

Institute for Advancing Translational Medicine in Bone and Joint Diseases

Research output: Contribution to journal › Review article › peer-review

25 Citations (Scopus)

Abstract

Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass and deterioration of bone microarchitecture, which results in increased bone fragility and fracture risk. Casein kinase 2-interacting protein-1 (CKIP-1) is a protein that plays an important role in regulation of bone formation. The effect of CKIP-1 on bone formation is mainly mediated through negative regulation of the bone morphogenetic protein pathway. In addition, CKIP-1 has an important role in the progression of osteoporosis. This review provides a summary of the recent studies on the role of CKIP-1 in osteoporosis development and treatment.

Original language	English
Pages (from-to)	173-178
Number of pages	6
Journal	Bone and Joint Research
Volume	7
Issue number	2
DOIs	https://doi.org/10.1302/2046-3758.72.BJR-2017-0172.R1
Publication status	Published - Feb 2018

Scopus Subject Areas

Surgery
Orthopedics and Sports Medicine

User-Defined Keywords

BMP pathway
Bone formation
CKIP-1
Osteoporosis

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10.1302/2046-3758.72.BJR-2017-0172.R1

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title = "The role of CKIP-1 in osteoporosis development and treatment",

abstract = "Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass and deterioration of bone microarchitecture, which results in increased bone fragility and fracture risk. Casein kinase 2-interacting protein-1 (CKIP-1) is a protein that plays an important role in regulation of bone formation. The effect of CKIP-1 on bone formation is mainly mediated through negative regulation of the bone morphogenetic protein pathway. In addition, CKIP-1 has an important role in the progression of osteoporosis. This review provides a summary of the recent studies on the role of CKIP-1 in osteoporosis development and treatment.",

keywords = "BMP pathway, Bone formation, CKIP-1, Osteoporosis",

author = "X. Peng and X. Wu and J. Zhang and G. Zhang and G. Li and X. Pan",

note = "Funding Information: The work was partially supported by grants from Research Grants Council of the Hong Kong Special Administrative Region, China (Project No. 14119115, 14160917, 9054014 N_CityU102/15, T13-402/17-N); National Natural Science Foundation of China (81371946, 81430049 and 81772322); Hong Kong Innovation Technology Commission Funds (ITS/UIM-305) and grants from the Shenzhen Science and Technology Innovation Council of China (JCYJ20150630165236960, JSGG20160229195900623 and JCYJ20150402152005636), Sanming Project of medicine in Shenzhen (SZSM20150602). Publisher copyright: {\textcopyright} 2018 Peng et al.",

year = "2018",

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doi = "10.1302/2046-3758.72.BJR-2017-0172.R1",

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AU - Peng, X.

AU - Wu, X.

AU - Zhang, J.

AU - Zhang, G.

AU - Li, G.

AU - Pan, X.

N1 - Funding Information: The work was partially supported by grants from Research Grants Council of the Hong Kong Special Administrative Region, China (Project No. 14119115, 14160917, 9054014 N_CityU102/15, T13-402/17-N); National Natural Science Foundation of China (81371946, 81430049 and 81772322); Hong Kong Innovation Technology Commission Funds (ITS/UIM-305) and grants from the Shenzhen Science and Technology Innovation Council of China (JCYJ20150630165236960, JSGG20160229195900623 and JCYJ20150402152005636), Sanming Project of medicine in Shenzhen (SZSM20150602). Publisher copyright: © 2018 Peng et al.

PY - 2018/2

Y1 - 2018/2

N2 - Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass and deterioration of bone microarchitecture, which results in increased bone fragility and fracture risk. Casein kinase 2-interacting protein-1 (CKIP-1) is a protein that plays an important role in regulation of bone formation. The effect of CKIP-1 on bone formation is mainly mediated through negative regulation of the bone morphogenetic protein pathway. In addition, CKIP-1 has an important role in the progression of osteoporosis. This review provides a summary of the recent studies on the role of CKIP-1 in osteoporosis development and treatment.

AB - Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass and deterioration of bone microarchitecture, which results in increased bone fragility and fracture risk. Casein kinase 2-interacting protein-1 (CKIP-1) is a protein that plays an important role in regulation of bone formation. The effect of CKIP-1 on bone formation is mainly mediated through negative regulation of the bone morphogenetic protein pathway. In addition, CKIP-1 has an important role in the progression of osteoporosis. This review provides a summary of the recent studies on the role of CKIP-1 in osteoporosis development and treatment.

KW - BMP pathway

KW - Bone formation

KW - CKIP-1

KW - Osteoporosis

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The role of CKIP-1 in osteoporosis development and treatment

Abstract

Scopus Subject Areas

User-Defined Keywords

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