The role of AMP-activated protein kinase as a potential target of treatment of hepatocellular carcinoma

Xue Jiang, Hor-Yue Tan, Shanshan Teng, Yau-Tuen Chan, Di Wang*, Ning Wang*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

56 Citations (Scopus)

Abstract

Background: Hepatocellular carcinoma (HCC) is the fifth most frequent cancer worldwide with a very high recurrence rate and very dismal prognosis. Diagnosis and treatment in HCC remain difficult, and the identification of new therapeutic targets is necessary for a better outcome of HCC treatment. AMP-Activated Protein Kinase (AMPK) is an essential intracellular energy sensor that plays multiple roles in cellular physiology and the pathological development of chronic diseases. Recent studies have highlighted the important regulation of AMPK in HCC. This review aims to comprehensively and critically summarize the role of AMPK in HCC. 

Methods: Original studies were retrieved from NCBI database with keywords including AMPK and HCC, which were analyzed with extensive reading. Results: Dysregulation of the kinase activity and expression of AMPK was observed in HCC, which was correlated with survival of the patients. Loss of AMPK in HCC cells may proceed cell cycle progression, proliferation, survival, migration, and invasion through different oncogenic molecules and pathways. 

Conclusions: We identified several AMPK activators which may possess potential anti-HCC function, and discussed the clinical perspective on the use of AMPK activators for HCC therapy.

Original languageEnglish
Article number647
Number of pages16
JournalCancers
Volume11
Issue number5
DOIs
Publication statusPublished - May 2019

Scopus Subject Areas

  • Oncology
  • Cancer Research

User-Defined Keywords

  • hepatocellular carcinoma
  • AMPK
  • proliferation and survival
  • invasion and metastasis
  • cancer metabolism
  • AMPK activators

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