TY - JOUR
T1 - The role of AMP-activated protein kinase as a potential target of treatment of hepatocellular carcinoma
AU - Jiang, Xue
AU - Tan, Hor-Yue
AU - Teng, Shanshan
AU - Chan, Yau-Tuen
AU - Wang, Di
AU - Wang, Ning
N1 - Funding Information:
Funding: This work is supported by the Health and Medical Fund of Hong Kong S.A.R. (Reference No.: 15162961).
Publisher Copyright:
© 2019, MDPI AG. All rights reserved.
PY - 2019/5
Y1 - 2019/5
N2 - Background: Hepatocellular carcinoma (HCC) is the fifth most frequent cancer worldwide with a very high recurrence rate and very dismal prognosis. Diagnosis and treatment in HCC remain difficult, and the identification of new therapeutic targets is necessary for a better outcome of HCC treatment. AMP-Activated Protein Kinase (AMPK) is an essential intracellular energy sensor that plays multiple roles in cellular physiology and the pathological development of chronic diseases. Recent studies have highlighted the important regulation of AMPK in HCC. This review aims to comprehensively and critically summarize the role of AMPK in HCC. Methods: Original studies were retrieved from NCBI database with keywords including AMPK and HCC, which were analyzed with extensive reading. Results: Dysregulation of the kinase activity and expression of AMPK was observed in HCC, which was correlated with survival of the patients. Loss of AMPK in HCC cells may proceed cell cycle progression, proliferation, survival, migration, and invasion through different oncogenic molecules and pathways. Conclusions: We identified several AMPK activators which may possess potential anti-HCC function, and discussed the clinical perspective on the use of AMPK activators for HCC therapy.
AB - Background: Hepatocellular carcinoma (HCC) is the fifth most frequent cancer worldwide with a very high recurrence rate and very dismal prognosis. Diagnosis and treatment in HCC remain difficult, and the identification of new therapeutic targets is necessary for a better outcome of HCC treatment. AMP-Activated Protein Kinase (AMPK) is an essential intracellular energy sensor that plays multiple roles in cellular physiology and the pathological development of chronic diseases. Recent studies have highlighted the important regulation of AMPK in HCC. This review aims to comprehensively and critically summarize the role of AMPK in HCC. Methods: Original studies were retrieved from NCBI database with keywords including AMPK and HCC, which were analyzed with extensive reading. Results: Dysregulation of the kinase activity and expression of AMPK was observed in HCC, which was correlated with survival of the patients. Loss of AMPK in HCC cells may proceed cell cycle progression, proliferation, survival, migration, and invasion through different oncogenic molecules and pathways. Conclusions: We identified several AMPK activators which may possess potential anti-HCC function, and discussed the clinical perspective on the use of AMPK activators for HCC therapy.
KW - hepatocellular carcinoma
KW - AMPK
KW - proliferation and survival
KW - invasion and metastasis
KW - cancer metabolism
KW - AMPK activators
UR - http://www.scopus.com/inward/record.url?scp=85066973466&partnerID=8YFLogxK
U2 - 10.3390/cancers11050647
DO - 10.3390/cancers11050647
M3 - Journal article
AN - SCOPUS:85066973466
SN - 2072-6694
VL - 11
JO - Cancers
JF - Cancers
IS - 5
M1 - 647
ER -
