TY - JOUR
T1 - The protective effects of taurine and fish oil supplementation on PM2.5-induced heart dysfunction among aged mice
T2 - A random double-blind study
AU - Yang, Shiyi
AU - Wen, Luyao
AU - Chai, Xuyang
AU - Song, Yuanyuan
AU - Chen, Xin
AU - Chen, Zhi Feng
AU - Li, Ruijin
AU - Dong, Chuan
AU - Qi, Zenghua
AU - Cai, Zongwei
N1 - Funding information:
This work was supported by the General Research Fund from Hong Kong Research Grants Council ( 12303320 ), the Natural Science Foundation of Guangdong Province ( 2019A1515011294 ), the Science and Technology Planning Project of Guangdong Province ( 2020B1212030008 ) and the National Key Research and Development Project ( 2019YFC1804604 ).
Publisher Copyright:
© 2022 Elsevier B.V. All rights reserved.
PY - 2022/12/10
Y1 - 2022/12/10
N2 - As it is nearly impossible to reduce PM2.5 concentrations in most cities to safe limits in a short period of time, dietary supplementation presents a promising approach for mitigating the adverse effects of PM2.5 exposure. A cross-sectional study showed that the elderly population of Linfen (PM2.5: 102 μg/m3) exhibited significantly lower serum taurine levels, as well as higher oxidative stress levels and cardiovascular health risks, than the corresponding population in Guangzhou (PM2.5: 39 μg/m3). We conducted a random double-blind study on aged mice that employed a “real-world” PM2.5 exposure system to simulate the conditions of Linfen with the aim of investigating the protective effects of taurine and fish oil supplementation on PM2.5-induced heart dysfunction. When compared with the placebo group, supplementation with taurine and fish oil not only maintained normal taurine levels, but also suppressed oxidative stress and inflammation in aged mice subjected to high concentrations of PM2.5. Variations in heart rate, contractile function, cardiac oxidative stress, inflammation and fibrosis among different groups of aged mice were used to clarify the beneficial effects of taurine and fish oil supplementation. Our results not only revealed the protective effects of taurine and fish oil supplementation on heart dysfunction induced by PM2.5 exposure from the aged mice experiments and also provided new means for the elderly to resist PM2.5 pollution at the individual level.
AB - As it is nearly impossible to reduce PM2.5 concentrations in most cities to safe limits in a short period of time, dietary supplementation presents a promising approach for mitigating the adverse effects of PM2.5 exposure. A cross-sectional study showed that the elderly population of Linfen (PM2.5: 102 μg/m3) exhibited significantly lower serum taurine levels, as well as higher oxidative stress levels and cardiovascular health risks, than the corresponding population in Guangzhou (PM2.5: 39 μg/m3). We conducted a random double-blind study on aged mice that employed a “real-world” PM2.5 exposure system to simulate the conditions of Linfen with the aim of investigating the protective effects of taurine and fish oil supplementation on PM2.5-induced heart dysfunction. When compared with the placebo group, supplementation with taurine and fish oil not only maintained normal taurine levels, but also suppressed oxidative stress and inflammation in aged mice subjected to high concentrations of PM2.5. Variations in heart rate, contractile function, cardiac oxidative stress, inflammation and fibrosis among different groups of aged mice were used to clarify the beneficial effects of taurine and fish oil supplementation. Our results not only revealed the protective effects of taurine and fish oil supplementation on heart dysfunction induced by PM2.5 exposure from the aged mice experiments and also provided new means for the elderly to resist PM2.5 pollution at the individual level.
KW - Fish oil
KW - Heart function
KW - PM2.5
KW - Protective effect
KW - Taurine
UR - http://www.scopus.com/inward/record.url?scp=85136250638&partnerID=8YFLogxK
U2 - 10.1016/j.scitotenv.2022.157966
DO - 10.1016/j.scitotenv.2022.157966
M3 - Journal article
C2 - 35964740
AN - SCOPUS:85136250638
SN - 0048-9697
VL - 851
JO - Science of the Total Environment
JF - Science of the Total Environment
M1 - 157966
ER -
