The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration

Perminder S. Sachdev; Darren M. Lipnicki; Nicole A. Kochan; John D. Crawford; Anbupalam Thalamuthu; Gavin Andrews; Carol Brayne; Fiona E. Matthews; Blossom C. M. Stephan; Richard B. Lipton; Mindy J. Katz; Karen Ritchie; Isabelle Carrière; Marie-Laure Ancelin; Linda C. W. Lam; Candy H. Y. Wong; Ada W. T. Fung; Antonio Guaita; Roberta Vaccaro; Annalisa Davin; Mary Ganguli; Hiroko Dodge; Tiffany Hughes; Kaarin J. Anstey; Nicolas Cherbuin; Peter Butterworth; Tze Pin Ng; Qi Gao; Simone Reppermund; Henry Brodaty; Nicole Schupf; Jennifer Manly; Yaakov Stern; Antonio Lobo; Raúl Lopez-Anton; Javier Santabárbara; Cohort Studies of Memory in an International Consortium (COSMIC)

doi:10.1371/journal.pone.0142388

The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration

Perminder S. Sachdev^*, Darren M. Lipnicki, Nicole A. Kochan, John D. Crawford, Anbupalam Thalamuthu, Gavin Andrews, Carol Brayne, Fiona E. Matthews, Blossom C. M. Stephan, Richard B. Lipton, Mindy J. Katz, Karen Ritchie, Isabelle Carrière, Marie-Laure Ancelin, Linda C. W. Lam, Candy H. Y. Wong, Ada W. T. Fung, Antonio Guaita, Roberta Vaccaro, Annalisa DavinMary Ganguli, Hiroko Dodge, Tiffany Hughes, Kaarin J. Anstey, Nicolas Cherbuin, Peter Butterworth, Tze Pin Ng, Qi Gao, Simone Reppermund, Henry Brodaty, Nicole Schupf, Jennifer Manly, Yaakov Stern, Antonio Lobo, Raúl Lopez-Anton, Javier Santabárbara, Cohort Studies of Memory in an International Consortium (COSMIC)

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

241 Citations (Scopus)

Abstract

Background: Changes in criteria and differences in populations studied and methodology have produced a wide range of prevalence estimates for mild cognitive impairment (MCI).

Methods: Uniform criteria were applied to harmonized data from 11 studies from USA, Europe, Asia and Australia, and MCI prevalence estimates determined using three separate definitions of cognitive impairment.

Results: The published range of MCI prevalence estimates was 5.0%–36.7%. This was reduced with all cognitive impairment definitions: performance in the bottom 6.681% (3.2%–10.8%); Clinical Dementia Rating of 0.5 (1.8%–14.9%); Mini-Mental State Examination score of 24–27 (2.1%–20.7%). Prevalences using the first definition were 5.9% overall, and increased with age (P < .001) but were unaffected by sex or the main races/ethnicities investigated (Whites and Chinese). Not completing high school increased the likelihood of MCI (P ≤ .01).

Conclusion: Applying uniform criteria to harmonized data greatly reduced the variation in MCI prevalence internationally.

Original language	English
Article number	e0142388
Journal	PLoS ONE
Volume	10
Issue number	11
DOIs	https://doi.org/10.1371/journal.pone.0142388
Publication status	Published - 5 Nov 2015

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Sachdev, P. S., Lipnicki, D. M., Kochan, N. A., Crawford, J. D., Thalamuthu, A., Andrews, G., Brayne, C., Matthews, F. E., Stephan, B. C. M., Lipton, R. B., Katz, M. J., Ritchie, K., Carrière, I., Ancelin, M.-L., Lam, L. C. W., Wong, C. H. Y., Fung, A. W. T., Guaita, A., Vaccaro, R., ... Cohort Studies of Memory in an International Consortium (COSMIC) (2015). The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration. PLoS ONE, 10(11), Article e0142388. https://doi.org/10.1371/journal.pone.0142388

@article{a34f05c4d1f54c08bd52fbc33c2c31de,

title = "The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration",

abstract = "Background: Changes in criteria and differences in populations studied and methodology have produced a wide range of prevalence estimates for mild cognitive impairment (MCI).Methods: Uniform criteria were applied to harmonized data from 11 studies from USA, Europe, Asia and Australia, and MCI prevalence estimates determined using three separate definitions of cognitive impairment.Results: The published range of MCI prevalence estimates was 5.0%–36.7%. This was reduced with all cognitive impairment definitions: performance in the bottom 6.681% (3.2%–10.8%); Clinical Dementia Rating of 0.5 (1.8%–14.9%); Mini-Mental State Examination score of 24–27 (2.1%–20.7%). Prevalences using the first definition were 5.9% overall, and increased with age (P < .001) but were unaffected by sex or the main races/ethnicities investigated (Whites and Chinese). Not completing high school increased the likelihood of MCI (P ≤ .01).Conclusion: Applying uniform criteria to harmonized data greatly reduced the variation in MCI prevalence internationally.",

author = "Sachdev, {Perminder S.} and Lipnicki, {Darren M.} and Kochan, {Nicole A.} and Crawford, {John D.} and Anbupalam Thalamuthu and Gavin Andrews and Carol Brayne and Matthews, {Fiona E.} and Stephan, {Blossom C. M.} and Lipton, {Richard B.} and Katz, {Mindy J.} and Karen Ritchie and Isabelle Carri{\`e}re and Marie-Laure Ancelin and Lam, {Linda C. W.} and Wong, {Candy H. Y.} and Fung, {Ada W. T.} and Antonio Guaita and Roberta Vaccaro and Annalisa Davin and Mary Ganguli and Hiroko Dodge and Tiffany Hughes and Anstey, {Kaarin J.} and Nicolas Cherbuin and Peter Butterworth and Ng, {Tze Pin} and Qi Gao and Simone Reppermund and Henry Brodaty and Nicole Schupf and Jennifer Manly and Yaakov Stern and Antonio Lobo and Ra{\'u}l Lopez-Anton and Javier Santab{\'a}rbara and {Cohort Studies of Memory in an International Consortium (COSMIC)}",

note = "Funding information: National Health and Medical Research Council of Australia Program Grant (ID 568969; PSS). For the contributing studies: Major awards from the UK Medical Research Council and the Department of Health (CB, FEM, BCMS); National Institute on Health/National Institute on Aging grants (5P01 AG003949, 1R03 AG045474; RBL, MJK); Novartis (KR, MLA, IC); Mr. Lai Seung Hung & Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund, and an educational fund from Eisai (LCWL, CHYW, AWTF); Fondazione Golgi Cenci and Federazione Alzheimer Italia (AG, RV, AD); National Institute on Aging, National Institutes of Health, United States Department of Health and Human Services (Grant # R01AG07562; MG, HD, TH); National Health and Medical Research Council of Australia (Grants 973302, 179805, 157125 and 1002160; KJA, NC, PB); Research grants (No. 03/121/17/214 and No. 08/1/21/19/567) from the Biomedical Research Council, Agency for Science, Technology and Research (A*STAR) in Singapore (TPN, QG); National Health & Medical Research Council of Australia Program Grant (ID 350833; PSS, DML, NAK, JDC, AT, GA, SR, HB); National Institute of Health/National Institute on Aging (Grants # R01 AG037212, P01 AG07232; NS, JM, YS); Fondo de Investigaci{\'o}n Sanitaria, Instituto de Salud Carlos III, Spanish Ministry of Health, Madrid, Spain (Grants 94/1562, 97/1321E, 98/0103, 01/0255, 03/0815, 06/0617, and G03/128) and Pfizer Foundation, Madrid (AL, RLA, JS). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher copyright: {\textcopyright} 2015 Sachdev et al.",

year = "2015",

month = nov,

day = "5",

doi = "10.1371/journal.pone.0142388",

language = "English",

volume = "10",

journal = "PLoS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "11",

}

Sachdev, PS, Lipnicki, DM, Kochan, NA, Crawford, JD, Thalamuthu, A, Andrews, G, Brayne, C, Matthews, FE, Stephan, BCM, Lipton, RB, Katz, MJ, Ritchie, K, Carrière, I, Ancelin, M-L, Lam, LCW, Wong, CHY, Fung, AWT, Guaita, A, Vaccaro, R, Davin, A, Ganguli, M, Dodge, H, Hughes, T, Anstey, KJ, Cherbuin, N, Butterworth, P, Ng, TP, Gao, Q, Reppermund, S, Brodaty, H, Schupf, N, Manly, J, Stern, Y, Lobo, A, Lopez-Anton, R, Santabárbara, J & Cohort Studies of Memory in an International Consortium (COSMIC) 2015, 'The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration', PLoS ONE, vol. 10, no. 11, e0142388. https://doi.org/10.1371/journal.pone.0142388

TY - JOUR

T1 - The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions

T2 - The COSMIC Collaboration

AU - Sachdev, Perminder S.

AU - Lipnicki, Darren M.

AU - Kochan, Nicole A.

AU - Crawford, John D.

AU - Thalamuthu, Anbupalam

AU - Andrews, Gavin

AU - Brayne, Carol

AU - Matthews, Fiona E.

AU - Stephan, Blossom C. M.

AU - Lipton, Richard B.

AU - Katz, Mindy J.

AU - Ritchie, Karen

AU - Carrière, Isabelle

AU - Ancelin, Marie-Laure

AU - Lam, Linda C. W.

AU - Wong, Candy H. Y.

AU - Fung, Ada W. T.

AU - Guaita, Antonio

AU - Vaccaro, Roberta

AU - Davin, Annalisa

AU - Ganguli, Mary

AU - Dodge, Hiroko

AU - Hughes, Tiffany

AU - Anstey, Kaarin J.

AU - Cherbuin, Nicolas

AU - Butterworth, Peter

AU - Ng, Tze Pin

AU - Gao, Qi

AU - Reppermund, Simone

AU - Brodaty, Henry

AU - Schupf, Nicole

AU - Manly, Jennifer

AU - Stern, Yaakov

AU - Lobo, Antonio

AU - Lopez-Anton, Raúl

AU - Santabárbara, Javier

AU - Cohort Studies of Memory in an International Consortium (COSMIC)

N1 - Funding information: National Health and Medical Research Council of Australia Program Grant (ID 568969; PSS). For the contributing studies: Major awards from the UK Medical Research Council and the Department of Health (CB, FEM, BCMS); National Institute on Health/National Institute on Aging grants (5P01 AG003949, 1R03 AG045474; RBL, MJK); Novartis (KR, MLA, IC); Mr. Lai Seung Hung & Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund, and an educational fund from Eisai (LCWL, CHYW, AWTF); Fondazione Golgi Cenci and Federazione Alzheimer Italia (AG, RV, AD); National Institute on Aging, National Institutes of Health, United States Department of Health and Human Services (Grant # R01AG07562; MG, HD, TH); National Health and Medical Research Council of Australia (Grants 973302, 179805, 157125 and 1002160; KJA, NC, PB); Research grants (No. 03/121/17/214 and No. 08/1/21/19/567) from the Biomedical Research Council, Agency for Science, Technology and Research (A*STAR) in Singapore (TPN, QG); National Health & Medical Research Council of Australia Program Grant (ID 350833; PSS, DML, NAK, JDC, AT, GA, SR, HB); National Institute of Health/National Institute on Aging (Grants # R01 AG037212, P01 AG07232; NS, JM, YS); Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, Spanish Ministry of Health, Madrid, Spain (Grants 94/1562, 97/1321E, 98/0103, 01/0255, 03/0815, 06/0617, and G03/128) and Pfizer Foundation, Madrid (AL, RLA, JS). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher copyright: © 2015 Sachdev et al.

PY - 2015/11/5

Y1 - 2015/11/5

N2 - Background: Changes in criteria and differences in populations studied and methodology have produced a wide range of prevalence estimates for mild cognitive impairment (MCI).Methods: Uniform criteria were applied to harmonized data from 11 studies from USA, Europe, Asia and Australia, and MCI prevalence estimates determined using three separate definitions of cognitive impairment.Results: The published range of MCI prevalence estimates was 5.0%–36.7%. This was reduced with all cognitive impairment definitions: performance in the bottom 6.681% (3.2%–10.8%); Clinical Dementia Rating of 0.5 (1.8%–14.9%); Mini-Mental State Examination score of 24–27 (2.1%–20.7%). Prevalences using the first definition were 5.9% overall, and increased with age (P < .001) but were unaffected by sex or the main races/ethnicities investigated (Whites and Chinese). Not completing high school increased the likelihood of MCI (P ≤ .01).Conclusion: Applying uniform criteria to harmonized data greatly reduced the variation in MCI prevalence internationally.

AB - Background: Changes in criteria and differences in populations studied and methodology have produced a wide range of prevalence estimates for mild cognitive impairment (MCI).Methods: Uniform criteria were applied to harmonized data from 11 studies from USA, Europe, Asia and Australia, and MCI prevalence estimates determined using three separate definitions of cognitive impairment.Results: The published range of MCI prevalence estimates was 5.0%–36.7%. This was reduced with all cognitive impairment definitions: performance in the bottom 6.681% (3.2%–10.8%); Clinical Dementia Rating of 0.5 (1.8%–14.9%); Mini-Mental State Examination score of 24–27 (2.1%–20.7%). Prevalences using the first definition were 5.9% overall, and increased with age (P < .001) but were unaffected by sex or the main races/ethnicities investigated (Whites and Chinese). Not completing high school increased the likelihood of MCI (P ≤ .01).Conclusion: Applying uniform criteria to harmonized data greatly reduced the variation in MCI prevalence internationally.

UR - http://europepmc.org/abstract/med/26539987

UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-84951268191&doi=10.1371%2fjournal.pone.0142388&partnerID=40&md5=cf21c387360050b1c5604ec609ec374d

U2 - 10.1371/journal.pone.0142388

DO - 10.1371/journal.pone.0142388

M3 - Journal article

C2 - 26539987

SN - 1932-6203

VL - 10

JO - PLoS ONE

JF - PLoS ONE

IS - 11

M1 - e0142388

ER -

The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration

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