The Prevalence of Mild Cognitive Impairment in Diverse Geographical and Ethnocultural Regions: The COSMIC Collaboration

Perminder S. Sachdev*, Darren M. Lipnicki, Nicole A. Kochan, John D. Crawford, Anbupalam Thalamuthu, Gavin Andrews, Carol Brayne, Fiona E. Matthews, Blossom C. M. Stephan, Richard B. Lipton, Mindy J. Katz, Karen Ritchie, Isabelle Carrière, Marie-Laure Ancelin, Linda C. W. Lam, Candy H. Y. Wong, Ada W. T. Fung, Antonio Guaita, Roberta Vaccaro, Annalisa DavinMary Ganguli, Hiroko Dodge, Tiffany Hughes, Kaarin J. Anstey, Nicolas Cherbuin, Peter Butterworth, Tze Pin Ng, Qi Gao, Simone Reppermund, Henry Brodaty, Nicole Schupf, Jennifer Manly, Yaakov Stern, Antonio Lobo, Raúl Lopez-Anton, Javier Santabárbara, Cohort Studies of Memory in an International Consortium (COSMIC)

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

229 Citations (Scopus)


Background: Changes in criteria and differences in populations studied and methodology have produced a wide range of prevalence estimates for mild cognitive impairment (MCI).

Methods: Uniform criteria were applied to harmonized data from 11 studies from USA, Europe, Asia and Australia, and MCI prevalence estimates determined using three separate definitions of cognitive impairment.

Results: The published range of MCI prevalence estimates was 5.0%–36.7%. This was reduced with all cognitive impairment definitions: performance in the bottom 6.681% (3.2%–10.8%); Clinical Dementia Rating of 0.5 (1.8%–14.9%); Mini-Mental State Examination score of 24–27 (2.1%–20.7%). Prevalences using the first definition were 5.9% overall, and increased with age (P < .001) but were unaffected by sex or the main races/ethnicities investigated (Whites and Chinese). Not completing high school increased the likelihood of MCI (P ≤ .01).

Conclusion: Applying uniform criteria to harmonized data greatly reduced the variation in MCI prevalence internationally.

Original languageEnglish
Article numbere0142388
JournalPLoS ONE
Issue number11
Publication statusPublished - 5 Nov 2015


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