The potential of 2-oxoglutarate oxygenases acting on nucleic acids as therapeutic targets

Armin Thalhammer; Wei Shen Aik; Eleanor A.L. Bagg; Christopher J. Schofield

doi:10.1016/j.ddstr.2012.02.002

The potential of 2-oxoglutarate oxygenases acting on nucleic acids as therapeutic targets

Armin Thalhammer
, Wei Shen Aik
, Eleanor A.L. Bagg
, Christopher J. Schofield^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Review article › peer-review

14 Citations (Scopus)

Abstract

Human 2-oxoglutarate dependent oxygenases, including histone demethylases and hypoxia inducible transcription factor hydroxylases, catalyze posttranslational modifications and are being pursued as targets for cancer, anemia and ischemic and inflammatory diseases. Nucleic acid-modifying 2OG oxygenases (NAOX) catalyze 5-methylcytosine oxidation, tRNA hydroxylation, and the dealkylation of nucleobases; NAOX have roles in cell differentiation, nucleic acid repair and metabolic regulation. We review recent functional and pathophysiological studies on NAOX and discuss emerging therapeutic opportunities with the aim of stimulating further studies on NAOX inhibition.

Original language	English
Pages (from-to)	e91-e100
Number of pages	10
Journal	Drug Discovery Today: Therapeutic Strategies
Volume	9
Issue number	2-3
DOIs	https://doi.org/10.1016/j.ddstr.2012.02.002
Publication status	Published - Sept 2012

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@article{b6107424bd0a4ee693b8541525981e06,

title = "The potential of 2-oxoglutarate oxygenases acting on nucleic acids as therapeutic targets",

abstract = "Human 2-oxoglutarate dependent oxygenases, including histone demethylases and hypoxia inducible transcription factor hydroxylases, catalyze posttranslational modifications and are being pursued as targets for cancer, anemia and ischemic and inflammatory diseases. Nucleic acid-modifying 2OG oxygenases (NAOX) catalyze 5-methylcytosine oxidation, tRNA hydroxylation, and the dealkylation of nucleobases; NAOX have roles in cell differentiation, nucleic acid repair and metabolic regulation. We review recent functional and pathophysiological studies on NAOX and discuss emerging therapeutic opportunities with the aim of stimulating further studies on NAOX inhibition.",

author = "Armin Thalhammer and Aik, \{Wei Shen\} and Bagg, \{Eleanor A.L.\} and Schofield, \{Christopher J.\}",

note = "Funding Information: We thank the Wellcome Trust, the Biotechnology and Biological Sciences Research Council, the European Research Council, and Pfizer for funding our work related to 2OG oxygenases acting on nucleic acids. We thank our colleagues for contributions to work on oxygenases and apologize for noncomprehensive citations. Publisher copyright: {\textcopyright} 2012 Elsevier Ltd.",

year = "2012",

month = sep,

doi = "10.1016/j.ddstr.2012.02.002",

language = "English",

volume = "9",

pages = "e91--e100",

journal = "Drug Discovery Today: Therapeutic Strategies",

issn = "1740-6773",

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}

TY - JOUR

T1 - The potential of 2-oxoglutarate oxygenases acting on nucleic acids as therapeutic targets

AU - Thalhammer, Armin

AU - Aik, Wei Shen

AU - Bagg, Eleanor A.L.

AU - Schofield, Christopher J.

N1 - Funding Information: We thank the Wellcome Trust, the Biotechnology and Biological Sciences Research Council, the European Research Council, and Pfizer for funding our work related to 2OG oxygenases acting on nucleic acids. We thank our colleagues for contributions to work on oxygenases and apologize for noncomprehensive citations. Publisher copyright: © 2012 Elsevier Ltd.

PY - 2012/9

Y1 - 2012/9

N2 - Human 2-oxoglutarate dependent oxygenases, including histone demethylases and hypoxia inducible transcription factor hydroxylases, catalyze posttranslational modifications and are being pursued as targets for cancer, anemia and ischemic and inflammatory diseases. Nucleic acid-modifying 2OG oxygenases (NAOX) catalyze 5-methylcytosine oxidation, tRNA hydroxylation, and the dealkylation of nucleobases; NAOX have roles in cell differentiation, nucleic acid repair and metabolic regulation. We review recent functional and pathophysiological studies on NAOX and discuss emerging therapeutic opportunities with the aim of stimulating further studies on NAOX inhibition.

AB - Human 2-oxoglutarate dependent oxygenases, including histone demethylases and hypoxia inducible transcription factor hydroxylases, catalyze posttranslational modifications and are being pursued as targets for cancer, anemia and ischemic and inflammatory diseases. Nucleic acid-modifying 2OG oxygenases (NAOX) catalyze 5-methylcytosine oxidation, tRNA hydroxylation, and the dealkylation of nucleobases; NAOX have roles in cell differentiation, nucleic acid repair and metabolic regulation. We review recent functional and pathophysiological studies on NAOX and discuss emerging therapeutic opportunities with the aim of stimulating further studies on NAOX inhibition.

UR - https://www.scopus.com/pages/publications/84871464403

U2 - 10.1016/j.ddstr.2012.02.002

DO - 10.1016/j.ddstr.2012.02.002

M3 - Review article

AN - SCOPUS:84871464403

SN - 1740-6773

VL - 9

SP - e91-e100

JO - Drug Discovery Today: Therapeutic Strategies

JF - Drug Discovery Today: Therapeutic Strategies

IS - 2-3

ER -

The potential of 2-oxoglutarate oxygenases acting on nucleic acids as therapeutic targets

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