TY - JOUR
T1 - The potential of 2-oxoglutarate oxygenases acting on nucleic acids as therapeutic targets
AU - Thalhammer, Armin
AU - Aik, Wei Shen
AU - Bagg, Eleanor A.L.
AU - Schofield, Christopher J.
N1 - Funding Information:
We thank the Wellcome Trust, the Biotechnology and Biological Sciences Research Council, the European Research Council, and Pfizer for funding our work related to 2OG oxygenases acting on nucleic acids. We thank our colleagues for contributions to work on oxygenases and apologize for noncomprehensive citations.
Publisher copyright:
© 2012 Elsevier Ltd.
PY - 2012/9
Y1 - 2012/9
N2 - Human 2-oxoglutarate dependent oxygenases, including histone demethylases and hypoxia inducible transcription factor hydroxylases, catalyze posttranslational modifications and are being pursued as targets for cancer, anemia and ischemic and inflammatory diseases. Nucleic acid-modifying 2OG oxygenases (NAOX) catalyze 5-methylcytosine oxidation, tRNA hydroxylation, and the dealkylation of nucleobases; NAOX have roles in cell differentiation, nucleic acid repair and metabolic regulation. We review recent functional and pathophysiological studies on NAOX and discuss emerging therapeutic opportunities with the aim of stimulating further studies on NAOX inhibition.
AB - Human 2-oxoglutarate dependent oxygenases, including histone demethylases and hypoxia inducible transcription factor hydroxylases, catalyze posttranslational modifications and are being pursued as targets for cancer, anemia and ischemic and inflammatory diseases. Nucleic acid-modifying 2OG oxygenases (NAOX) catalyze 5-methylcytosine oxidation, tRNA hydroxylation, and the dealkylation of nucleobases; NAOX have roles in cell differentiation, nucleic acid repair and metabolic regulation. We review recent functional and pathophysiological studies on NAOX and discuss emerging therapeutic opportunities with the aim of stimulating further studies on NAOX inhibition.
UR - http://www.scopus.com/inward/record.url?scp=84871464403&partnerID=8YFLogxK
U2 - 10.1016/j.ddstr.2012.02.002
DO - 10.1016/j.ddstr.2012.02.002
M3 - Review article
AN - SCOPUS:84871464403
SN - 1740-6773
VL - 9
SP - e91-e100
JO - Drug Discovery Today: Therapeutic Strategies
JF - Drug Discovery Today: Therapeutic Strategies
IS - 2-3
ER -
