The nature of the sensitiser substituent determines quenching sensitivity and protein affinity and influences the design of emissive lanthanide complexes as optical probes for intracellular use

Filip Kielar; Ga Lai Law; Elizabeth J. New; David Parker

doi:10.1039/b804369h

The nature of the sensitiser substituent determines quenching sensitivity and protein affinity and influences the design of emissive lanthanide complexes as optical probes for intracellular use

Filip Kielar
, Ga Lai Law
, Elizabeth J. New
, David Parker^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

65 Citations (Scopus)

Abstract

Introduction of different substituents at the 7-position of a sensitising azaxanthone group in a series of emissive Eu and Tb complexes can determine the intracellular uptake and distribution profile and may be linked to modulation of protein affinity.

Original language	English
Pages (from-to)	2256-2258
Number of pages	3
Journal	Organic and Biomolecular Chemistry
Volume	6
Issue number	13
DOIs	https://doi.org/10.1039/b804369h
Publication status	Published - 16 May 2008

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10.1039/b804369h

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@article{deee680714c54a3f98dc4899f67e1ff1,

title = "The nature of the sensitiser substituent determines quenching sensitivity and protein affinity and influences the design of emissive lanthanide complexes as optical probes for intracellular use",

abstract = "Introduction of different substituents at the 7-position of a sensitising azaxanthone group in a series of emissive Eu and Tb complexes can determine the intracellular uptake and distribution profile and may be linked to modulation of protein affinity.",

author = "Filip Kielar and Law, \{Ga Lai\} and New, \{Elizabeth J.\} and David Parker",

note = "We thank EPSRC, the EC networks EMIL and DIMI and the Royal Society for support, and the Association of Commonwealth Universities for a scholarship (EJN). Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2008",

year = "2008",

month = may,

day = "16",

doi = "10.1039/b804369h",

language = "English",

volume = "6",

pages = "2256--2258",

journal = "Organic and Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

number = "13",

}

The nature of the sensitiser substituent determines quenching sensitivity and protein affinity and influences the design of emissive lanthanide complexes as optical probes for intracellular use. / Kielar, Filip; Law, Ga Lai; New, Elizabeth J. et al.
In: Organic and Biomolecular Chemistry, Vol. 6, No. 13, 16.05.2008, p. 2256-2258.

Research output: Contribution to journal › Journal article › peer-review

TY - JOUR

T1 - The nature of the sensitiser substituent determines quenching sensitivity and protein affinity and influences the design of emissive lanthanide complexes as optical probes for intracellular use

AU - Kielar, Filip

AU - Law, Ga Lai

AU - New, Elizabeth J.

AU - Parker, David

N1 - We thank EPSRC, the EC networks EMIL and DIMI and the Royal Society for support, and the Association of Commonwealth Universities for a scholarship (EJN). Publisher Copyright: © The Royal Society of Chemistry 2008

PY - 2008/5/16

Y1 - 2008/5/16

N2 - Introduction of different substituents at the 7-position of a sensitising azaxanthone group in a series of emissive Eu and Tb complexes can determine the intracellular uptake and distribution profile and may be linked to modulation of protein affinity.

AB - Introduction of different substituents at the 7-position of a sensitising azaxanthone group in a series of emissive Eu and Tb complexes can determine the intracellular uptake and distribution profile and may be linked to modulation of protein affinity.

UR - https://www.scopus.com/pages/publications/45449088932

UR - https://pubs.rsc.org/en/content/articlelanding/2008/ob/b804369h

U2 - 10.1039/b804369h

DO - 10.1039/b804369h

M3 - Journal article

C2 - 18563255

AN - SCOPUS:45449088932

SN - 1477-0520

VL - 6

SP - 2256

EP - 2258

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 13

ER -

The nature of the sensitiser substituent determines quenching sensitivity and protein affinity and influences the design of emissive lanthanide complexes as optical probes for intracellular use

Abstract

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