The microbial metabolome in metabolic-associated fatty liver disease

Mengci Li, Cynthia Rajani, Xiaojiao Zheng, Wei Jia*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Metabolism-associated fatty liver disease (MAFLD) is defined as the presence of excess fat in the liver in the absence of excess alcohol consumption and metabolic dysfunction. It has also been described as the hepatic manifestation of metabolic syndrome. The incidence of MAFLD has been reported to be 43–60% in diabetics, ~90% in patients with hyperlipidemia, and 91% in morbidly obese patients. Risk factors that have been associated with the development of MAFLD include male gender, increasing age, obesity, insulin resistance, diabetes, and hyperlipidemia. All of these risk factors have been linked to alterations of the gut microbiota, that is, gut dysbiosis. MAFLD can progress to non-alcoholic steatohepatitis with the presence of inflammation and ballooning, which can deteriorate into cirrhosis, MAFLD-related hepatocellular carcinoma, and liver failure. In this review, we will be focused on the role of the gut microbial metabolome in the development, progression, and potential treatment of MAFLD.

Original languageEnglish
Pages (from-to)15-23
Number of pages9
JournalJournal of Gastroenterology and Hepatology
Volume37
Issue number1
DOIs
Publication statusPublished - Jan 2022

Scopus Subject Areas

  • Gastroenterology
  • Hepatology

User-Defined Keywords

  • Fatty liver (see NAFLD)
  • Gastroenterology
  • Hepatology
  • Metabolism
  • Microbial pathogenesis
  • NASH

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