The mechanics of protein sweet spots

Qian-Yuan Tang

doi:10.1038/s41567-025-02826-8

The mechanics of protein sweet spots

Qian-Yuan Tang^*

^*Corresponding author for this work

Department of Physics

Research output: Contribution to journal › Journal article › peer-review

1 Citation (Scopus)

Abstract

Proteins rely on dynamic flexibility to function as life’s molecular machines. Now, artificial intelligence predictions and mechanics experiments reveal how mutations at specific protein sites modulate enzyme catalysis, advancing protein design.

Original language	English
Pages (from-to)	695-696
Number of pages	2
Journal	Nature Physics
Volume	21
Issue number	5
Early online date	28 Mar 2025
DOIs	https://doi.org/10.1038/s41567-025-02826-8
Publication status	Published - May 2025

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 9 Industry, Innovation, and Infrastructure

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10.1038/s41567-025-02826-8

Cite this

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title = "The mechanics of protein sweet spots",

abstract = "Proteins rely on dynamic flexibility to function as life{\textquoteright}s molecular machines. Now, artificial intelligence predictions and mechanics experiments reveal how mutations at specific protein sites modulate enzyme catalysis, advancing protein design.",

author = "Qian-Yuan Tang",

note = "Publisher copyright: {\textcopyright} 2025, Springer Nature Limited ",

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doi = "10.1038/s41567-025-02826-8",

language = "English",

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AB - Proteins rely on dynamic flexibility to function as life’s molecular machines. Now, artificial intelligence predictions and mechanics experiments reveal how mutations at specific protein sites modulate enzyme catalysis, advancing protein design.

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DO - 10.1038/s41567-025-02826-8

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JO - Nature Physics

JF - Nature Physics

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The mechanics of protein sweet spots

Abstract

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