The mechanics of protein sweet spots

Qian-Yuan Tang

doi:10.1038/s41567-025-02826-8

The mechanics of protein sweet spots

Qian-Yuan Tang^*

^*Corresponding author for this work

Department of Physics

Research output: Contribution to journal › Journal article › peer-review

Abstract

Proteins rely on dynamic flexibility to function as life’s molecular machines. Now, artificial intelligence predictions and mechanics experiments reveal how mutations at specific protein sites modulate enzyme catalysis, advancing protein design.

Original language	English
Number of pages	2
Journal	Nature Physics
DOIs	https://doi.org/10.1038/s41567-025-02826-8
Publication status	E-pub ahead of print - 28 Mar 2025

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10.1038/s41567-025-02826-8

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title = "The mechanics of protein sweet spots",

abstract = "Proteins rely on dynamic flexibility to function as life{\textquoteright}s molecular machines. Now, artificial intelligence predictions and mechanics experiments reveal how mutations at specific protein sites modulate enzyme catalysis, advancing protein design.",

author = "Qian-Yuan Tang",

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M3 - Journal article

SN - 1745-2473

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The mechanics of protein sweet spots

Abstract

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