TY - JOUR
T1 - The level and prevalence of depression and anxiety among patients with different subtypes of irritable bowel syndrome
T2 - a network meta-analysis
AU - Hu, Zhichao
AU - Li, Meixuan
AU - Yao, Liang
AU - Wang, Yinshu
AU - Wang, Enkang
AU - Yuan, Jianye
AU - Wang, Fengyun
AU - Yang, Kehu
AU - Bian, Zhaoxiang
AU - Zhong, Linda L. D.
N1 - Funding Information:
This study was supported by Faculty Research Grant, Hong Kong Baptist University (Ref. SCM/025/KY, Hong Kong Baptist University). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Publisher copyright:
Copyright © 2021, The Author(s)
PY - 2021/1/7
Y1 - 2021/1/7
N2 - Background: Irritable bowel syndrome (IBS) is a very common functional bowel disorder. However, the difference of depression and anxiety comorbidities among different IBS subtypes is still not well evaluated. This study aims to investigate the difference in the level and prevalence of depression and anxiety among healthy controls and patients with different subtypes of IBS.Methods: PubMed, EMBASE and the Cochrane library were searched systematically until August 17, 2020. Studies that investigated depression and/or anxiety levels or prevalence among different IBS-subtype patients measured at baseline or the same point were included. Network meta-analysis was conducted to analyze standardized mean difference (SMD) of anxiety and depression levels, and single arm meta-analysis was performed for prevalence of anxiety and depression among different IBS subtypes.Results: Eighteen studies involving 7095 participants were included. Network meta-analyses results showed healthy controls had a lower level of depression than IBS with mixed symptoms of constipation and diarrhea (IBS-M) [SMD = − 1.57; 95% confidence interval (CI) − 2.21, − 0.92], IBS with constipation (IBS-C) (SMD = − 1.53; 95% CI − 2.13, − 0.93) and IBS with diarrhea (IBS-D)(SMD = − 1.41; 95% CI − 1.97, − 0.85), while no significant difference was found between IBS unclassified (IBS-U) and healthy controls (SMD = − 0.58; 95% CI − 2.15, 1.00). There was also no significant difference in the level of depression among different IBS subtypes patients. The results of anxiety were similar to depression. Ranking probability showed that IBS-M was associated with the highest level of depression and anxiety symptoms, followed by IBS-C/IBS-D and IBS-U. Single-arm meta-analysis showed IBS-C had the highest prevalence of depression (38%) and anxiety (40%), followed by IBS-D, IBS-M and IBS-U.Conclusion: The results indicated that IBS-M was more likely to be associated with a higher level of depression and anxiety, and the prevalence of depression and anxiety in IBS-C was highest. The psychological screening and appropriate psychotherapy are needed for patients with IBS-C, IBS-D and IBS-M instead of IBS-U.
AB - Background: Irritable bowel syndrome (IBS) is a very common functional bowel disorder. However, the difference of depression and anxiety comorbidities among different IBS subtypes is still not well evaluated. This study aims to investigate the difference in the level and prevalence of depression and anxiety among healthy controls and patients with different subtypes of IBS.Methods: PubMed, EMBASE and the Cochrane library were searched systematically until August 17, 2020. Studies that investigated depression and/or anxiety levels or prevalence among different IBS-subtype patients measured at baseline or the same point were included. Network meta-analysis was conducted to analyze standardized mean difference (SMD) of anxiety and depression levels, and single arm meta-analysis was performed for prevalence of anxiety and depression among different IBS subtypes.Results: Eighteen studies involving 7095 participants were included. Network meta-analyses results showed healthy controls had a lower level of depression than IBS with mixed symptoms of constipation and diarrhea (IBS-M) [SMD = − 1.57; 95% confidence interval (CI) − 2.21, − 0.92], IBS with constipation (IBS-C) (SMD = − 1.53; 95% CI − 2.13, − 0.93) and IBS with diarrhea (IBS-D)(SMD = − 1.41; 95% CI − 1.97, − 0.85), while no significant difference was found between IBS unclassified (IBS-U) and healthy controls (SMD = − 0.58; 95% CI − 2.15, 1.00). There was also no significant difference in the level of depression among different IBS subtypes patients. The results of anxiety were similar to depression. Ranking probability showed that IBS-M was associated with the highest level of depression and anxiety symptoms, followed by IBS-C/IBS-D and IBS-U. Single-arm meta-analysis showed IBS-C had the highest prevalence of depression (38%) and anxiety (40%), followed by IBS-D, IBS-M and IBS-U.Conclusion: The results indicated that IBS-M was more likely to be associated with a higher level of depression and anxiety, and the prevalence of depression and anxiety in IBS-C was highest. The psychological screening and appropriate psychotherapy are needed for patients with IBS-C, IBS-D and IBS-M instead of IBS-U.
KW - Anxiety
KW - Depression
KW - Irritable bowel syndrome
KW - Meta-analysis
UR - http://www.scopus.com/inward/record.url?scp=85098853079&partnerID=8YFLogxK
U2 - 10.1186/s12876-020-01593-5
DO - 10.1186/s12876-020-01593-5
M3 - Journal article
C2 - 33413140
AN - SCOPUS:85098853079
SN - 1471-230X
VL - 21
JO - BMC Gastroenterology
JF - BMC Gastroenterology
IS - 1
M1 - 23
ER -
