The JAK2/STAT3 pathway is involved in the anti-melanoma effects of atractylenolide I

Xiuqiong FU, Ji Yao Chou, Ting Li, Pei Li Zhu, Jun Kui Li, Cheng Le Yin, Tao Su, Hui Guo, Kin Wah Lee, Muhammad Jahangir Hossen, Gui Xin Chou*, Zhiling YU

*Corresponding author for this work

Research output: Contribution to journalLetterpeer-review

15 Citations (Scopus)

Abstract

In this study, we aimed to investigate the anti-melanoma effects and the JAK2/STAT3 pathway-related mechanism of action of atractylenolide I in human melanoma cells. Our results showed that atractylenolide I effectively reduced viability, induced apoptosis and inhibited migration of melanoma cells. Meanwhile, atractylenolide I decreased the protein expression levels of phospho-JAK2 and phospho-STAT3, and in turn downregulated the mRNA levels of STAT3-targeted genes, including Bcl-xL, MMP-2 and MMP-9. Furthermore, the cytotoxic effect of atractylenolide I was attenuated in STAT3-overactivated A375 cells. These findings indicate that inhibition of JAK2/STAT3 signalling contributes to the anti-melanoma effects of atractylenolide I.

Original languageEnglish
Pages (from-to)201-204
Number of pages4
JournalExperimental Dermatology
Volume27
Issue number2
DOIs
Publication statusPublished - 1 Feb 2018

Scopus Subject Areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

User-Defined Keywords

  • apoptosis
  • Cytotoxicity
  • metastasis
  • molecular pathways
  • targeted therapy

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