Abstract
In this study, we aimed to investigate the anti-melanoma effects and the JAK2/STAT3 pathway-related mechanism of action of atractylenolide I in human melanoma cells. Our results showed that atractylenolide I effectively reduced viability, induced apoptosis and inhibited migration of melanoma cells. Meanwhile, atractylenolide I decreased the protein expression levels of phospho-JAK2 and phospho-STAT3, and in turn downregulated the mRNA levels of STAT3-targeted genes, including Bcl-xL, MMP-2 and MMP-9. Furthermore, the cytotoxic effect of atractylenolide I was attenuated in STAT3-overactivated A375 cells. These findings indicate that inhibition of JAK2/STAT3 signalling contributes to the anti-melanoma effects of atractylenolide I.
Original language | English |
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Pages (from-to) | 201-204 |
Number of pages | 4 |
Journal | Experimental Dermatology |
Volume | 27 |
Issue number | 2 |
Early online date | 27 Oct 2017 |
DOIs | |
Publication status | Published - Feb 2018 |
Scopus Subject Areas
- Biochemistry
- Molecular Biology
- Dermatology
User-Defined Keywords
- apoptosis
- Cytotoxicity
- metastasis
- molecular pathways
- targeted therapy