The interplay between parental care and OPRM1 in reward responsiveness

Quanhe Wang; Yuting Yang; Rongjun Yu; Wenping Zhao; Mingyang Wang; Yi Wang; Wenxuan Guo; Linlin He; Pingyuan Gong

doi:10.1016/j.psyneuen.2022.105845

The interplay between parental care and OPRM1 in reward responsiveness

Quanhe Wang, Yuting Yang, Rongjun Yu, Wenping Zhao, Mingyang Wang, Yi Wang, Wenxuan Guo, Linlin He, Pingyuan Gong^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

1 Citation (Scopus)

Abstract

The Reinforcement Sensitivity Theory (RST) explains a variety of reward-motivated behaviors as the result of the activation of biologically-based systems. Inspired by the influences of parental bonding and opioid peptide on reward system, we investigated the contributions of parental bonding and mu-opioid receptor gene (OPRM1) towards motivation systems (i.e., the BAS, BIS-anxiety, and FFFS-fear). Results indicated that (1) parental care was negatively related to FFFS-fear, but parental overprotection was positively related to both FFFS-fear and BIS-anxiety; (2) parental care significantly interacted with OPRM1 rs1799971 in reward responsiveness with diathesis-stress model. Poor parental care reduced reward responsiveness among individuals with the G allele, but not those with the AA genotype. These findings from this study demonstrate a new gene-environment interactive mechanism of the RST.

Original language	English
Article number	105845
Number of pages	6
Journal	Psychoneuroendocrinology
Volume	143
DOIs	https://doi.org/10.1016/j.psyneuen.2022.105845
Publication status	Published - Sept 2022

User-Defined Keywords

Gene-environment interaction
Mu-opioid receptor
Parental care
Parental overprotection
Reinforcement Sensitivity Theory
Reward responsiveness

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10.1016/j.psyneuen.2022.105845

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title = "The interplay between parental care and OPRM1 in reward responsiveness",

abstract = "The Reinforcement Sensitivity Theory (RST) explains a variety of reward-motivated behaviors as the result of the activation of biologically-based systems. Inspired by the influences of parental bonding and opioid peptide on reward system, we investigated the contributions of parental bonding and mu-opioid receptor gene (OPRM1) towards motivation systems (i.e., the BAS, BIS-anxiety, and FFFS-fear). Results indicated that (1) parental care was negatively related to FFFS-fear, but parental overprotection was positively related to both FFFS-fear and BIS-anxiety; (2) parental care significantly interacted with OPRM1 rs1799971 in reward responsiveness with diathesis-stress model. Poor parental care reduced reward responsiveness among individuals with the G allele, but not those with the AA genotype. These findings from this study demonstrate a new gene-environment interactive mechanism of the RST.",

keywords = "Gene-environment interaction, Mu-opioid receptor, Parental care, Parental overprotection, Reinforcement Sensitivity Theory, Reward responsiveness",

author = "Quanhe Wang and Yuting Yang and Rongjun Yu and Wenping Zhao and Mingyang Wang and Yi Wang and Wenxuan Guo and Linlin He and Pingyuan Gong",

year = "2022",

month = sep,

doi = "10.1016/j.psyneuen.2022.105845",

language = "English",

volume = "143",

journal = "Psychoneuroendocrinology",

issn = "0306-4530",

publisher = "Elsevier Ltd.",

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TY - JOUR

T1 - The interplay between parental care and OPRM1 in reward responsiveness

AU - Wang, Quanhe

AU - Yang, Yuting

AU - Yu, Rongjun

AU - Zhao, Wenping

AU - Wang, Mingyang

AU - Wang, Yi

AU - Guo, Wenxuan

AU - He, Linlin

AU - Gong, Pingyuan

PY - 2022/9

Y1 - 2022/9

N2 - The Reinforcement Sensitivity Theory (RST) explains a variety of reward-motivated behaviors as the result of the activation of biologically-based systems. Inspired by the influences of parental bonding and opioid peptide on reward system, we investigated the contributions of parental bonding and mu-opioid receptor gene (OPRM1) towards motivation systems (i.e., the BAS, BIS-anxiety, and FFFS-fear). Results indicated that (1) parental care was negatively related to FFFS-fear, but parental overprotection was positively related to both FFFS-fear and BIS-anxiety; (2) parental care significantly interacted with OPRM1 rs1799971 in reward responsiveness with diathesis-stress model. Poor parental care reduced reward responsiveness among individuals with the G allele, but not those with the AA genotype. These findings from this study demonstrate a new gene-environment interactive mechanism of the RST.

AB - The Reinforcement Sensitivity Theory (RST) explains a variety of reward-motivated behaviors as the result of the activation of biologically-based systems. Inspired by the influences of parental bonding and opioid peptide on reward system, we investigated the contributions of parental bonding and mu-opioid receptor gene (OPRM1) towards motivation systems (i.e., the BAS, BIS-anxiety, and FFFS-fear). Results indicated that (1) parental care was negatively related to FFFS-fear, but parental overprotection was positively related to both FFFS-fear and BIS-anxiety; (2) parental care significantly interacted with OPRM1 rs1799971 in reward responsiveness with diathesis-stress model. Poor parental care reduced reward responsiveness among individuals with the G allele, but not those with the AA genotype. These findings from this study demonstrate a new gene-environment interactive mechanism of the RST.

KW - Gene-environment interaction

KW - Mu-opioid receptor

KW - Parental care

KW - Parental overprotection

KW - Reinforcement Sensitivity Theory

KW - Reward responsiveness

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U2 - 10.1016/j.psyneuen.2022.105845

DO - 10.1016/j.psyneuen.2022.105845

M3 - Journal article

C2 - 35779341

AN - SCOPUS:85133631198

SN - 0306-4530

VL - 143

JO - Psychoneuroendocrinology

JF - Psychoneuroendocrinology

M1 - 105845

ER -

The interplay between parental care and OPRM1 in reward responsiveness

Abstract

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