Abstract
The Reinforcement Sensitivity Theory (RST) explains a variety of reward-motivated behaviors as the result of the activation of biologically-based systems. Inspired by the influences of parental bonding and opioid peptide on reward system, we investigated the contributions of parental bonding and mu-opioid receptor gene (OPRM1) towards motivation systems (i.e., the BAS, BIS-anxiety, and FFFS-fear). Results indicated that (1) parental care was negatively related to FFFS-fear, but parental overprotection was positively related to both FFFS-fear and BIS-anxiety; (2) parental care significantly interacted with OPRM1 rs1799971 in reward responsiveness with diathesis-stress model. Poor parental care reduced reward responsiveness among individuals with the G allele, but not those with the AA genotype. These findings from this study demonstrate a new gene-environment interactive mechanism of the RST.
Original language | English |
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Article number | 105845 |
Number of pages | 6 |
Journal | Psychoneuroendocrinology |
Volume | 143 |
DOIs | |
Publication status | Published - Sept 2022 |
Scopus Subject Areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology
- Endocrine and Autonomic Systems
- Psychiatry and Mental health
- Biological Psychiatry
User-Defined Keywords
- Gene-environment interaction
- Mu-opioid receptor
- Parental care
- Parental overprotection
- Reinforcement Sensitivity Theory
- Reward responsiveness