The interplay between parental care and OPRM1 in reward responsiveness

Quanhe Wang, Yuting Yang, Rongjun Yu, Wenping Zhao, Mingyang Wang, Yi Wang, Wenxuan Guo, Linlin He, Pingyuan Gong*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

1 Citation (Scopus)


The Reinforcement Sensitivity Theory (RST) explains a variety of reward-motivated behaviors as the result of the activation of biologically-based systems. Inspired by the influences of parental bonding and opioid peptide on reward system, we investigated the contributions of parental bonding and mu-opioid receptor gene (OPRM1) towards motivation systems (i.e., the BAS, BIS-anxiety, and FFFS-fear). Results indicated that (1) parental care was negatively related to FFFS-fear, but parental overprotection was positively related to both FFFS-fear and BIS-anxiety; (2) parental care significantly interacted with OPRM1 rs1799971 in reward responsiveness with diathesis-stress model. Poor parental care reduced reward responsiveness among individuals with the G allele, but not those with the AA genotype. These findings from this study demonstrate a new gene-environment interactive mechanism of the RST.

Original languageEnglish
Article number105845
Number of pages6
Publication statusPublished - Sept 2022

Scopus Subject Areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Psychiatry and Mental health
  • Biological Psychiatry

User-Defined Keywords

  • Gene-environment interaction
  • Mu-opioid receptor
  • Parental care
  • Parental overprotection
  • Reinforcement Sensitivity Theory
  • Reward responsiveness


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