The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome

Wai Po Chong; W. K. Eddie Ip; Gloria Hoi Wan Tso; Man Wai Ng; Wilfred Hing Sang Wong; Helen Ka Wai Law; Raymond W.H. Yung; Eudora Y. Chow; K. L. Au; Eric Y.T. Chan; Wilina Lim; J. S.Malik Peiris; Yu Lung Lau

doi:10.1186/1471-2334-6-82

The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome

Wai Po Chong
, W. K. Eddie Ip
, Gloria Hoi Wan Tso
, Man Wai Ng
, Wilfred Hing Sang Wong
, Helen Ka Wai Law
, Raymond W.H. Yung
, Eudora Y. Chow
, K. L. Au
, Eric Y.T. Chan
, Wilina Lim
, J. S.Malik Peiris
, Yu Lung Lau^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

86 Citations (Scopus)

Abstract

Background: Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-γ,TNF-α and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). Methods: A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-γ,TNF-α and IL-10 for their associations with SARS. Results: IFN- γ+874A allele was associated with susceptibility to SARS in a dose-dependent manner (P < 0.001). Individuals with IFN-γ +874 AA and AT genotype had a 5.19-fold (95% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of IL-10 and TNF-α were not associated with SARS susceptibility. Conclusion: IFN-γ+874A allele was shown to be a risk factor in SARS susceptibility.

Original language	English
Article number	82
Number of pages	4
Journal	BMC Infectious Diseases
Volume	6
DOIs	https://doi.org/10.1186/1471-2334-6-82
Publication status	Published - 4 May 2006

User-Defined Keywords

Severe Acute Respiratory Syndrome
Antiviral Response
Severe Acute Respiratory Syndrome Patient
Severe Acute Respiratory Syndrome Coronavirus

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10.1186/1471-2334-6-82

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@article{73191b86aa974d6aa3d88ac01a581d85,

title = "The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome",

abstract = "Background: Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-γ,TNF-α and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). Methods: A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-γ,TNF-α and IL-10 for their associations with SARS. Results: IFN- γ+874A allele was associated with susceptibility to SARS in a dose-dependent manner (P < 0.001). Individuals with IFN-γ +874 AA and AT genotype had a 5.19-fold (95\% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95\% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of IL-10 and TNF-α were not associated with SARS susceptibility. Conclusion: IFN-γ+874A allele was shown to be a risk factor in SARS susceptibility.",

keywords = "Severe Acute Respiratory Syndrome, Antiviral Response, Severe Acute Respiratory Syndrome Patient, Severe Acute Respiratory Syndrome Coronavirus",

author = "Chong, \{Wai Po\} and Ip, \{W. K. Eddie\} and Tso, \{Gloria Hoi Wan\} and Ng, \{Man Wai\} and Wong, \{Wilfred Hing Sang\} and Law, \{Helen Ka Wai\} and Yung, \{Raymond W.H.\} and Chow, \{Eudora Y.\} and Au, \{K. L.\} and Chan, \{Eric Y.T.\} and Wilina Lim and Peiris, \{J. S.Malik\} and Lau, \{Yu Lung\}",

year = "2006",

month = may,

day = "4",

doi = "10.1186/1471-2334-6-82",

language = "English",

volume = "6",

journal = "BMC Infectious Diseases",

issn = "1471-2334",

publisher = "BioMed Central Ltd.",

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TY - JOUR

T1 - The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome

AU - Chong, Wai Po

AU - Ip, W. K. Eddie

AU - Tso, Gloria Hoi Wan

AU - Ng, Man Wai

AU - Wong, Wilfred Hing Sang

AU - Law, Helen Ka Wai

AU - Yung, Raymond W.H.

AU - Chow, Eudora Y.

AU - Au, K. L.

AU - Chan, Eric Y.T.

AU - Lim, Wilina

AU - Peiris, J. S.Malik

AU - Lau, Yu Lung

PY - 2006/5/4

Y1 - 2006/5/4

N2 - Background: Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-γ,TNF-α and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). Methods: A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-γ,TNF-α and IL-10 for their associations with SARS. Results: IFN- γ+874A allele was associated with susceptibility to SARS in a dose-dependent manner (P < 0.001). Individuals with IFN-γ +874 AA and AT genotype had a 5.19-fold (95% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of IL-10 and TNF-α were not associated with SARS susceptibility. Conclusion: IFN-γ+874A allele was shown to be a risk factor in SARS susceptibility.

AB - Background: Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-γ,TNF-α and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). Methods: A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-γ,TNF-α and IL-10 for their associations with SARS. Results: IFN- γ+874A allele was associated with susceptibility to SARS in a dose-dependent manner (P < 0.001). Individuals with IFN-γ +874 AA and AT genotype had a 5.19-fold (95% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of IL-10 and TNF-α were not associated with SARS susceptibility. Conclusion: IFN-γ+874A allele was shown to be a risk factor in SARS susceptibility.

KW - Severe Acute Respiratory Syndrome

KW - Antiviral Response

KW - Severe Acute Respiratory Syndrome Patient

KW - Severe Acute Respiratory Syndrome Coronavirus

UR - https://www.scopus.com/pages/publications/33646891057

UR - http://europepmc.org/abstract/med/16672072

U2 - 10.1186/1471-2334-6-82

DO - 10.1186/1471-2334-6-82

M3 - Journal article

C2 - 16672072

SN - 1471-2334

VL - 6

JO - BMC Infectious Diseases

JF - BMC Infectious Diseases

M1 - 82

ER -

The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome

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