The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome

Wai Po Chong; W. K. Eddie Ip; Gloria Hoi Wan Tso; Man Wai Ng; Wilfred Hing Sang Wong; Helen Ka Wai Law; Raymond W.H. Yung; Eudora Y. Chow; K. L. Au; Eric Y.T. Chan; Wilina Lim; J. S.Malik Peiris; Yu Lung Lau

doi:10.1186/1471-2334-6-82

The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome

Wai Po Chong, W. K. Eddie Ip, Gloria Hoi Wan Tso, Man Wai Ng, Wilfred Hing Sang Wong, Helen Ka Wai Law, Raymond W.H. Yung, Eudora Y. Chow, K. L. Au, Eric Y.T. Chan, Wilina Lim, J. S.Malik Peiris, Yu Lung Lau^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

83 Citations (Scopus)

Abstract

Background: Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-γ,TNF-α and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). Methods: A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-γ,TNF-α and IL-10 for their associations with SARS. Results: IFN- γ+874A allele was associated with susceptibility to SARS in a dose-dependent manner (P < 0.001). Individuals with IFN-γ +874 AA and AT genotype had a 5.19-fold (95% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of IL-10 and TNF-α were not associated with SARS susceptibility. Conclusion: IFN-γ+874A allele was shown to be a risk factor in SARS susceptibility.

Original language	English
Article number	82
Number of pages	4
Journal	BMC Infectious Diseases
Volume	6
DOIs	https://doi.org/10.1186/1471-2334-6-82
Publication status	Published - 4 May 2006

Scopus Subject Areas

Infectious Diseases

User-Defined Keywords

Severe Acute Respiratory Syndrome
Antiviral Response
Severe Acute Respiratory Syndrome Patient
Severe Acute Respiratory Syndrome Coronavirus

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10.1186/1471-2334-6-82

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title = "The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome",

abstract = "Background: Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-γ,TNF-α and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). Methods: A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-γ,TNF-α and IL-10 for their associations with SARS. Results: IFN- γ+874A allele was associated with susceptibility to SARS in a dose-dependent manner (P < 0.001). Individuals with IFN-γ +874 AA and AT genotype had a 5.19-fold (95% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of IL-10 and TNF-α were not associated with SARS susceptibility. Conclusion: IFN-γ+874A allele was shown to be a risk factor in SARS susceptibility.",

keywords = "Severe Acute Respiratory Syndrome, Antiviral Response, Severe Acute Respiratory Syndrome Patient, Severe Acute Respiratory Syndrome Coronavirus",

author = "Chong, {Wai Po} and Ip, {W. K. Eddie} and Tso, {Gloria Hoi Wan} and Ng, {Man Wai} and Wong, {Wilfred Hing Sang} and Law, {Helen Ka Wai} and Yung, {Raymond W.H.} and Chow, {Eudora Y.} and Au, {K. L.} and Chan, {Eric Y.T.} and Wilina Lim and Peiris, {J. S.Malik} and Lau, {Yu Lung}",

year = "2006",

month = may,

day = "4",

doi = "10.1186/1471-2334-6-82",

language = "English",

volume = "6",

journal = "BMC Infectious Diseases",

issn = "1471-2334",

publisher = "BioMed Central Ltd.",

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T1 - The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome

AU - Chong, Wai Po

AU - Ip, W. K. Eddie

AU - Tso, Gloria Hoi Wan

AU - Ng, Man Wai

AU - Wong, Wilfred Hing Sang

AU - Law, Helen Ka Wai

AU - Yung, Raymond W.H.

AU - Chow, Eudora Y.

AU - Au, K. L.

AU - Chan, Eric Y.T.

AU - Lim, Wilina

AU - Peiris, J. S.Malik

AU - Lau, Yu Lung

PY - 2006/5/4

Y1 - 2006/5/4

N2 - Background: Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-γ,TNF-α and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). Methods: A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-γ,TNF-α and IL-10 for their associations with SARS. Results: IFN- γ+874A allele was associated with susceptibility to SARS in a dose-dependent manner (P < 0.001). Individuals with IFN-γ +874 AA and AT genotype had a 5.19-fold (95% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of IL-10 and TNF-α were not associated with SARS susceptibility. Conclusion: IFN-γ+874A allele was shown to be a risk factor in SARS susceptibility.

AB - Background: Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-γ,TNF-α and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). Methods: A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-γ,TNF-α and IL-10 for their associations with SARS. Results: IFN- γ+874A allele was associated with susceptibility to SARS in a dose-dependent manner (P < 0.001). Individuals with IFN-γ +874 AA and AT genotype had a 5.19-fold (95% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of IL-10 and TNF-α were not associated with SARS susceptibility. Conclusion: IFN-γ+874A allele was shown to be a risk factor in SARS susceptibility.

KW - Severe Acute Respiratory Syndrome

KW - Antiviral Response

KW - Severe Acute Respiratory Syndrome Patient

KW - Severe Acute Respiratory Syndrome Coronavirus

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VL - 6

JO - BMC Infectious Diseases

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M1 - 82

ER -

The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome

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