The influence of a half-marathon race upon cardiac troponin T release in adolescent runners

J. Nie*, K. P. George, Tom K K TONG, D. Gaze, Y. Tian, H. Lin, Q. Shi

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

25 Citations (Scopus)


Objectives: Post-exercise cardiac troponin T (cTnT) release has been widely reported in adult athletes but limited data is available for adolescents. The aim of this study was to determine the incidence and magnitude of cTnT appearance in a large group of adolescent runners, and to determine any association between cTnT release and personal characteristics of adolescents. Methods: We recruited 63 adolescent runners (mean±SD: age 16.4±1.5 years; 10 females) who all completed a simulated half-marathon race (an all-out 21-km run) during routine training. Personal data collected included age, training history, 21-km run performance as well as pre-post exercise serum cTnT levels. Serum cTnT was assayed using a 3rd generation assay. Results: At pre-exercise, cTnT concentrations were below the 0.01 μg/L cTnT detection limit of assay in 58/63 runners. The post-exercise cTnT level (range: <0.01-1.36 μg/L) was significantly (p<0.001) greater than that of the pre-exercise (range: <0.01-0.02 μg/L). After the exercise, 57 (90%) and 44 (70%) subjects had cTnT concentrations above the detection: 0.01, and clinical thresholds: 0.05 μg/L, respectively. Post-exercise cTnT was inversely correlated with training years (r=-0.25, p<0.05) and age (r=-0.31, p<0.05). Compared with runners who had trained for ≥3 years, runners with less training experience demonstrated increased post-race cTnT levels (p<0.01). Conclusion: cTnT increases are virtually universal among adolescent runners following a 21-km run during routine training and can reach levels typically diagnostic for acute myocardial infarction potentially initiating diagnostic dilemmas. Adolescents with less training experience had higher post-exercise cTnT.

Original languageEnglish
Pages (from-to)3452-3456
Number of pages5
JournalCurrent Medicinal Chemistry
Issue number23
Publication statusPublished - Aug 2011

Scopus Subject Areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

User-Defined Keywords

  • Adolescent athletes
  • Cardiac troponin T
  • Endurance exercise
  • Training


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