The in vivo release of 90Y from cyclic and acyclic ligand-antibody conjugates

A. Harrison; C. A. Walker; D. Parker; K. J. Jankowski; J. P.L. Cox; A. S. Craig; J. M. Sansom; N. R.A. Beeley; R. A. Boyce; L. Chaplin; M. A.W. Eaton; A. P.H. Farnsworth; K. Millar; A. T. Millican; A. M. Randall; S. K. Rhind; D. S. Secher; A. Turner

doi:10.1016/0883-2897(91)90107-V

The in vivo release of ⁹⁰Y from cyclic and acyclic ligand-antibody conjugates

A. Harrison
, C. A. Walker
, D. Parker
, K. J. Jankowski
, J. P.L. Cox
, A. S. Craig
, J. M. Sansom
, N. R.A. Beeley
, R. A. Boyce
, L. Chaplin
, M. A.W. Eaton
, A. P.H. Farnsworth
, K. Millar
, A. T. Millican
, A. M. Randall
, S. K. Rhind
, D. S. Secher
, A. Turner

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

86 Citations (Scopus)

Abstract

Yttrium binding ligands DOTA, caDTPA and CT-DTPA were each conjugated to monoclonal antibody B72.3, labelled with ⁹⁰Y and injected into mice in order to assess the in vivo inertness of the antibody-linked ⁹⁰Y-ligand complexes. Levels of ⁹⁰Y in femur shafts of the DOTA-B72.3 mice were low, being ~ 7 and 44%, respectively, of levels in the femur shafts of the caDTPA-B72.3 and CT-DTPA-B72.3 treated mice. This finding demonstrates the greater inertness and by implication the greater suitability for immunotherapy of the DOTA-⁹⁰Y complex.

Original language	English
Pages (from-to)	469-476
Number of pages	8
Journal	International Journal of Radiation Applications and Instrumentation
Volume	18
Issue number	5
DOIs	https://doi.org/10.1016/0883-2897(91)90107-V
Publication status	Published - Jul 1991

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10.1016/0883-2897(91)90107-V

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Harrison, A., Walker, C. A., Parker, D., Jankowski, K. J., Cox, J. P. L., Craig, A. S., Sansom, J. M., Beeley, N. R. A., Boyce, R. A., Chaplin, L., Eaton, M. A. W., Farnsworth, A. P. H., Millar, K., Millican, A. T., Randall, A. M., Rhind, S. K., Secher, D. S., & Turner, A. (1991). The in vivo release of ⁹⁰Y from cyclic and acyclic ligand-antibody conjugates. International Journal of Radiation Applications and Instrumentation, 18(5), 469-476. https://doi.org/10.1016/0883-2897(91)90107-V

@article{d8c3aa695b6f434b81ab21f5105384e4,

title = "The in vivo release of 90Y from cyclic and acyclic ligand-antibody conjugates",

abstract = "Yttrium binding ligands DOTA, caDTPA and CT-DTPA were each conjugated to monoclonal antibody B72.3, labelled with 90Y and injected into mice in order to assess the in vivo inertness of the antibody-linked 90Y-ligand complexes. Levels of 90Y in femur shafts of the DOTA-B72.3 mice were low, being \textasciitilde{} 7 and 44\%, respectively, of levels in the femur shafts of the caDTPA-B72.3 and CT-DTPA-B72.3 treated mice. This finding demonstrates the greater inertness and by implication the greater suitability for immunotherapy of the DOTA-90Y complex.",

author = "A. Harrison and Walker, \{C. A.\} and D. Parker and Jankowski, \{K. J.\} and Cox, \{J. P.L.\} and Craig, \{A. S.\} and Sansom, \{J. M.\} and Beeley, \{N. R.A.\} and Boyce, \{R. A.\} and L. Chaplin and Eaton, \{M. A.W.\} and Farnsworth, \{A. P.H.\} and K. Millar and Millican, \{A. T.\} and Randall, \{A. M.\} and Rhind, \{S. K.\} and Secher, \{D. S.\} and A. Turner",

note = "Publisher copyright: {\textcopyright} 1991 Published by Elsevier Inc.",

year = "1991",

month = jul,

doi = "10.1016/0883-2897(91)90107-V",

language = "English",

volume = "18",

pages = "469--476",

journal = "International Journal of Radiation Applications and Instrumentation",

issn = "0883-2897",

publisher = "Elsevier Inc.",

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}

Harrison, A, Walker, CA, Parker, D, Jankowski, KJ, Cox, JPL, Craig, AS, Sansom, JM, Beeley, NRA, Boyce, RA, Chaplin, L, Eaton, MAW, Farnsworth, APH, Millar, K, Millican, AT, Randall, AM, Rhind, SK, Secher, DS & Turner, A 1991, 'The in vivo release of ⁹⁰Y from cyclic and acyclic ligand-antibody conjugates', International Journal of Radiation Applications and Instrumentation, vol. 18, no. 5, pp. 469-476. https://doi.org/10.1016/0883-2897(91)90107-V

TY - JOUR

T1 - The in vivo release of 90Y from cyclic and acyclic ligand-antibody conjugates

AU - Harrison, A.

AU - Walker, C. A.

AU - Parker, D.

AU - Jankowski, K. J.

AU - Cox, J. P.L.

AU - Craig, A. S.

AU - Sansom, J. M.

AU - Beeley, N. R.A.

AU - Boyce, R. A.

AU - Chaplin, L.

AU - Eaton, M. A.W.

AU - Farnsworth, A. P.H.

AU - Millar, K.

AU - Millican, A. T.

AU - Randall, A. M.

AU - Rhind, S. K.

AU - Secher, D. S.

AU - Turner, A.

PY - 1991/7

Y1 - 1991/7

N2 - Yttrium binding ligands DOTA, caDTPA and CT-DTPA were each conjugated to monoclonal antibody B72.3, labelled with 90Y and injected into mice in order to assess the in vivo inertness of the antibody-linked 90Y-ligand complexes. Levels of 90Y in femur shafts of the DOTA-B72.3 mice were low, being ~ 7 and 44%, respectively, of levels in the femur shafts of the caDTPA-B72.3 and CT-DTPA-B72.3 treated mice. This finding demonstrates the greater inertness and by implication the greater suitability for immunotherapy of the DOTA-90Y complex.

AB - Yttrium binding ligands DOTA, caDTPA and CT-DTPA were each conjugated to monoclonal antibody B72.3, labelled with 90Y and injected into mice in order to assess the in vivo inertness of the antibody-linked 90Y-ligand complexes. Levels of 90Y in femur shafts of the DOTA-B72.3 mice were low, being ~ 7 and 44%, respectively, of levels in the femur shafts of the caDTPA-B72.3 and CT-DTPA-B72.3 treated mice. This finding demonstrates the greater inertness and by implication the greater suitability for immunotherapy of the DOTA-90Y complex.

UR - https://www.scopus.com/pages/publications/0025730436

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:A1991FT38800005?KeyUID=WOS:A1991FT38800005

U2 - 10.1016/0883-2897(91)90107-V

DO - 10.1016/0883-2897(91)90107-V

M3 - Journal article

C2 - 1917516

AN - SCOPUS:0025730436

SN - 0883-2897

VL - 18

SP - 469

EP - 476

JO - International Journal of Radiation Applications and Instrumentation

JF - International Journal of Radiation Applications and Instrumentation

IS - 5

ER -

The in vivo release of ⁹⁰Y from cyclic and acyclic ligand-antibody conjugates

Abstract

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