TY - JOUR
T1 - The genus Rosa and arthritis
T2 - Overview on pharmacological perspectives
AU - Cheng, Brian Chi Yan
AU - Fu, Xiu Qiong
AU - Guo, Hui
AU - Li, Ting
AU - Wu, Zheng Zhi
AU - Chan, Kelvin
AU - Yu, Zhi Ling
N1 - Funding Information:
This work was supported by grants JCYJ20140807091945050 , JCYJ20150630164505508 and JCYJ20160229210327924 from the Science, Technology and Innovation Commission of Shenzhen , 12125116 from Research Grants Council of Hong Kong ; 81673649 from National Natural Science Foundation of China ; 2016A030313007 form Guangdong Natural Science Foundation ; and FRG1/15-16/050 and FRG2/15-16/020 from the Hong Kong Baptist University .
PY - 2016/12/1
Y1 - 2016/12/1
N2 - The genus Rosa (roses) has long been used in traditional or folk medicine worldwide for the treatment of various types of arthritis including rheumatoid arthritis and osteoarthritis. The active constituents of Rosa spp., such as flavonoids, triterpenoids, and phytosterols, could act on different targets in the NF-κB signalling pathway, inhibit pro-inflammatory enzymes (e.g. MMPs and COX-2), lower the production of inflammatory cytokines and chemokines (e.g. TNF-α, IL-1β, IL-6, CCL5), and reduce oxidative stress, which in turn suppress inflammatory processes. Preclinical and clinical studies have demonstrated that these species possess analgesic, anti-arthritic, anti-inflammatory, anti-oxidative and bone-preserving activities. This review presents comprehensive overview of the mode and mechanism of action of various extracts, preparations, and active constituents from this genus. The dynamic beneficial effects of the products prepared from this genus in arthritis management are summarized. The Rosa genus is a treasure waiting for further exploration by researchers interested in the development of safe and effective anti-arthritic agents.
AB - The genus Rosa (roses) has long been used in traditional or folk medicine worldwide for the treatment of various types of arthritis including rheumatoid arthritis and osteoarthritis. The active constituents of Rosa spp., such as flavonoids, triterpenoids, and phytosterols, could act on different targets in the NF-κB signalling pathway, inhibit pro-inflammatory enzymes (e.g. MMPs and COX-2), lower the production of inflammatory cytokines and chemokines (e.g. TNF-α, IL-1β, IL-6, CCL5), and reduce oxidative stress, which in turn suppress inflammatory processes. Preclinical and clinical studies have demonstrated that these species possess analgesic, anti-arthritic, anti-inflammatory, anti-oxidative and bone-preserving activities. This review presents comprehensive overview of the mode and mechanism of action of various extracts, preparations, and active constituents from this genus. The dynamic beneficial effects of the products prepared from this genus in arthritis management are summarized. The Rosa genus is a treasure waiting for further exploration by researchers interested in the development of safe and effective anti-arthritic agents.
KW - Rheumatoid arthritis
KW - Rosa canina
KW - Rosa multiflora
KW - Rose hips
KW - Ursolic acid
KW - β-sitosterol
UR - http://www.scopus.com/inward/record.url?scp=84995602602&partnerID=8YFLogxK
U2 - 10.1016/j.phrs.2016.10.029
DO - 10.1016/j.phrs.2016.10.029
M3 - Review article
C2 - 27816506
AN - SCOPUS:84995602602
SN - 1043-6618
VL - 114
SP - 219
EP - 234
JO - Pharmacological Research
JF - Pharmacological Research
ER -