The genus Rosa and arthritis: Overview on pharmacological perspectives

Brian Chi Yan Cheng, Xiuqiong FU, Hui Guo, Ting Li, Zheng Zhi Wu, Kelvin Chan, Zhiling YU*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)

Abstract

The genus Rosa (roses) has long been used in traditional or folk medicine worldwide for the treatment of various types of arthritis including rheumatoid arthritis and osteoarthritis. The active constituents of Rosa spp., such as flavonoids, triterpenoids, and phytosterols, could act on different targets in the NF-κB signalling pathway, inhibit pro-inflammatory enzymes (e.g. MMPs and COX-2), lower the production of inflammatory cytokines and chemokines (e.g. TNF-α, IL-1β, IL-6, CCL5), and reduce oxidative stress, which in turn suppress inflammatory processes. Preclinical and clinical studies have demonstrated that these species possess analgesic, anti-arthritic, anti-inflammatory, anti-oxidative and bone-preserving activities. This review presents comprehensive overview of the mode and mechanism of action of various extracts, preparations, and active constituents from this genus. The dynamic beneficial effects of the products prepared from this genus in arthritis management are summarized. The Rosa genus is a treasure waiting for further exploration by researchers interested in the development of safe and effective anti-arthritic agents.

Original languageEnglish
Pages (from-to)219-234
Number of pages16
JournalPharmacological Research
Volume114
DOIs
Publication statusPublished - 1 Dec 2016

Scopus Subject Areas

  • Pharmacology

User-Defined Keywords

  • Rheumatoid arthritis
  • Rosa canina
  • Rosa multiflora
  • Rose hips
  • Ursolic acid
  • β-sitosterol

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