The Future of Genomic Research in Athletic Performance and Adaptation to Training

Guan Wang, Masashi Tanaka, Nir Eynon, Kathryn N. North, Alun G. Williams, Malcolm Collins, Colin N. Moran, Steven L. Britton, Noriyuki Fuku, Euan A. Ashley, Vassilis Klissouras, Alejandro Lucia, Ildus I. Ahmetov, Eco De Geus, Mohammed Alsayrafi, Yannis P. Pitsiladis*

*Corresponding author for this work

    Research output: Chapter in book/report/conference proceedingChapterpeer-review

    36 Citations (Scopus)

    Abstract

    Despite numerous attempts to discover genetic variants associated with elite athletic performance, an individual's trainability and injury predisposition, there has been limited progress to date. Past reliance on candidate gene studies focusing predominantly on genotyping a limited number of genetic variants in small, often heterogeneous cohorts has not generated results of practical significance. Hypothesis-free genome-wide approaches will in the future provide more comprehensive coverage and in-depth understanding of the biology underlying sports-related traits and related genetic mechanisms. Large, collaborative projects with sound experimental designs (e.g. clearly defined phenotypes, considerations and controls for sources of variability, and necessary replications) are required to produce meaningful results, especially when a hypothesis-free approach is used. It remains to be determined whether the novel approaches under current implementation will result in findings with real practical significance. This review will briefly summarize current and future directions in exercise genetics and genomics.

    Original languageEnglish
    Title of host publicationGenetics and Sports
    EditorsMichael Posthumus, Malcolm Collins
    Place of PublicationGermany
    PublisherS. Karger AG
    Pages55-67
    Number of pages13
    Edition2nd
    ISBN (Electronic)9783318030112
    ISBN (Print)9783318030105
    DOIs
    Publication statusPublished - 10 Jun 2016

    Publication series

    NameMedicine and Sport Science
    PublisherS. Karger AG
    Volume61
    ISSN (Print)0254-5020
    ISSN (Electronic)1662-2812

    Scopus Subject Areas

    • Orthopedics and Sports Medicine
    • Physical Therapy, Sports Therapy and Rehabilitation

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